A5031957092- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Trace Elements in Health
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Obsessive-Compulsive Spectrum Disorders
- Neonatal and fetal brain pathology
- Advanced biosensing and bioanalysis techniques
- Chronic Myeloid Leukemia Treatments
- Ion channel regulation and function
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Medicinal Plants and Neuroprotection
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- RNA Research and Splicing
- Urticaria and Related Conditions
- Piperaceae Chemical and Biological Studies
- Whipple's Disease and Interleukins
- Aluminum toxicity and tolerance in plants and animals
Children's Hospital of Zhejiang University
2012-2024
Fujian Medical University
2018-2024
Union Hospital
2018-2022
Abstract Evidence from experimental and clinical studies implicates immuno-inflammatory responses as playing an important role in epilepsy-induced brain injury. Captopril, angiotensin-converting enzyme inhibitor (ACEi), has previously been shown to suppress a variety of neurological diseases. However, the therapeutic potential captopril on epilepsy remains unclear. In present study, Sprague Dawley (SD) rats were intraperitoneally subjected kainic acid (KA) establish status epilepticus....
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that characterized by demyelination, axonal injury and neurological deterioration. Few medications are available for progressive MS, which associated with neuroinflammation confined to CNS compartment. Transient receptor potential melastatin 2 (TRPM2) calcium-permeable, non-selective cation channel plays pathological roles in wide range neuroinflammatory diseases; however, underlying molecular mechanisms TRPM2 remain...
Epilepsy is one of the most common neurological disorders. Neuroinflammation involving activation microglia and astrocytes constitutes an important mechanism in epileptogenesis. Transient receptor potential melastatin 2 (TRPM2) a calcium-permeable, non-selective cation channel that plays pathological roles various inflammation-related diseases. Our previous study demonstrated Trpm2 knockout exhibits therapeutic effects on pilocarpine-induced glial neuroinflammation. However, whether TRPM2...
Abstract Mitochondrial DNA (mtDNA) mutations have been associated with Leber’s hereditary optic neuropathy (LHON) and their pathophysiology remains poorly understood. In this study, we investigated the of a LHON susceptibility allele (m.3394T>C, p.30Y>H) in (MT)-ND1 gene. The incidence m.3394T>C mutation was 2.7% cohort 1741 probands LHON. Extremely low penetrances were observed 26 pedigrees carrying only mutation, while 21 families bearing m.3394T>C, together...
Pediatric epilepsy is a neurological condition that causes repeated and unprovoked seizures more common in 1-5-year-old children. Drug resistance has been indicated as key challenge improving the clinical outcomes of patients with pediatric epilepsy. In present study, we aimed to identify plasma small extracellular vesicles (sEVs) derived microRNAs (miRNAs) from samples children for predicting prognosis drug-resistant A total 90 clinically diagnosed [46 antiepileptic drug (AED)-responsive 44...
Abstract Aim: To conduct the clinical, genetic, and molecular characterization of 494 Han Chinese subjects with tic disorders (TD). Methods: In present study, we performed mutational analysis 22 mitochondrial tRNA genes in a large cohort TD via Sanger sequencing. These variants were then assessed for their pathogenic potential phylogenetic, functional, structural analyses. Results: A total 73 gene (49 known 24 novel) on identified. Among these, 18 that absent or <1% 485 control...
Background: Tic disorders (TD) are common neuropsychiatric among children and adolescents. It is controversial that trace elements may participate in the pathogenesis of TD. Our study aimed to investigate status zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) with TD, comparison healthy controls. Methods: The medical records eligible TD normal from January 1 December 31, 2018 outpatient clinic were retrospectively reviewed. clinical information all subjects collected including age, gender,...
Tic disorder (TD) is a common childhood-onset disease associated with abnormal development of brain networks involved in the motor and sensory processing. The underlying pathophysiological mechanisms TD are still unclear. An involvement immune its pathophysiology has been proposed. This study investigates association between changes cytokines etiology TD. Different expressions larger number samples our may provide new insights to field. levels (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were...
Over the past 50 years, great progress has been made in diagnosis and treatment of acute lymphoblastic leukemia (ALL), especially pediatric patients. However, early recurrence is still an important threat to survival In this study, we used integrated bioinformatics analysis look for biomarkers B-cell ALL (B-ALL) childhood adolescent Firstly, obtained gene expression profiles from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database Gene Expression Omnibus (GEO)...
β-Catenin is a key component of the canonical Wnt signaling pathway. It has been shown to have an important role in formation neuromuscular junction. Our previous studies showed that absence β-catenin, resting membrane potential (RMP) depolarized muscle cells and expression α2 subunit sodium/potassium adenosine triphosphatase (α2NKA) reduced. To understand underlying mechanisms, we investigated electrophysiologic properties primary cell line derived from mouse myoblasts (C2C12 cells) were...
Objective: To observe the effects of miR-21 knockout on proliferation and drug resistance in K562/G01 cells, to preliminarily explore mechanism imatinib sensitivity by knocking out cells. Methods: Using CRISPR/Cas9 knock gene single-cell-derived clones were obtained genomic DNA PCR screening, Sanger sequencing, real-time PCR. We used MTT cell colony formation assays assess proliferation, determined assay Annexin-Ⅴ-APC/7-AAD double staining flow cytometry. western blot, we examined potential...
Laser Tweezers Raman Spectroscopy (LTRS) is a combination of laser tweezers and spectroscopy. It physical tool based on the mechanical effects laser, which can be used to study single living cells in suspension fast non-destructive way. Our work aims establish methodology system LTRS rapidly non-destructively detect resistance acute lymphoblastic leukemia (ALL) provide new idea for evaluation ALL cells. Two specific adriamycin-resistant parental BALL-1 Nalm6 were included this study....
To investigate the correlation of