A5100772909- Phase-change materials and chalcogenides
- Chalcogenide Semiconductor Thin Films
- SARS-CoV-2 and COVID-19 Research
- Plant Molecular Biology Research
- Atherosclerosis and Cardiovascular Diseases
- Biochemical and Molecular Research
- Immune Response and Inflammation
- Dendrimers and Hyperbranched Polymers
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Plant Gene Expression Analysis
- CRISPR and Genetic Engineering
- Corneal Surgery and Treatments
- Bacterial Genetics and Biotechnology
- Mathematical and Theoretical Epidemiology and Ecology Models
- RNA Interference and Gene Delivery
- Immune responses and vaccinations
- Escherichia coli research studies
- Ophthalmology and Visual Impairment Studies
- Antibiotic Resistance in Bacteria
- Solid-state spectroscopy and crystallography
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- RNA modifications and cancer
Zhejiang University
2025
Ningbo University
2025
Zhejiang Wanli University
2024-2025
Sichuan University
2024
Xinxiang Medical University
2017-2024
Anhui Agricultural University
2016-2023
Shinshu University
2023
Xuchang University
2022-2023
Jinzhou Medical University
2023
City University of Macau
2023
Alginate lyases can fully degrade alginate into various size-defined unsaturated oligosaccharide products by β -elimination. Here, we identified the bifunctional endolytic lyase Aly35 from marine bacterium Vibrio sp. Strain H204. The enzyme is classified polysaccharide 7 superfamily and contains two catalytic domains. relationship function of domains are not well known. Thus, full-length recombinant its truncated proteins Aly35-CD1 (catalytic domain 1), Aly35-CD2 2 domain) were constructed....
Histone 3 Lys27 (H3K27) trimethyltransferase Ezh2 is implicated in the pathogenesis of autoimmune inflammation. Nevertheless, role macrophage/microglial activation remains to be defined. In this study, we identified that H3K27me3 or Ezh2, rather than functioning as a repressor, mediates toll-like receptor (TLR)-induced proinflammatory gene expression, and therefore depletion diminishes attenuates inflammation dextran sulfate sodium–induced colitis experimental encephalomyelitis. Mechanistic...
The drug/gene codelivery is a promising strategy for cancer treatment. Herein, to realize the of docetaxel and MMP-9 siRNA plasmid efficiently into tumor cells, star-shaped amphiphilic copolymer consisting hyperbranched polyglycerol derivative (HPG-C18) dendritic poly(l-lysine) (PLLD) was synthesized by click reaction between azido-modified HPG-C18 propargyl focal point PLLD. obtained HPG-C18-PLLD could form nanocomplexes with MMP-9, complexes showed good gene delivery ability in vitro...
Non-cell autonomous RNA silencing can spread from cell to and over long distances in animals plants. However, the genetic requirements signals involved plant mobile gene are poorly understood. Here, we identified a DICER-LIKE2 (DCL2)-dependent mechanism for systemic of posttranscriptional silencing, also known as (PTGS), Nicotiana benthamiana. Using suite transgenic DCL RNAi lines coupled with GFP reporter, demonstrated that N. benthamiana DCL1, DCL2, DCL3, DCL4 required produce microRNAs...
Abstract A novel star‐shaped polymer, porphyrin‐poly(L‐lysine) dendrons (PP‐PLLD), is synthesized by the click reaction between azido‐modified porphyrin and propargyl focal point poly(L‐lysine) dendrons. Its chemical structure characterized 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, gel permeation chromatography (GPC) analyses etc. Due to its amphiphilic property, obtained PP‐PLLD has a low critical micelle concentration in an aqueous solution, can load...
Abstract BACKGROUND Peptidomics combined with molecular docking is an effective alternative method for rapid screening of novel bioactive peptides in food. Buffalo milk as a potential source dipeptidyl peptidase‐IV (DPP‐IV) inhibitory has been less studied. and methods were employed to rapidly screen new DPP‐IV from buffalo milk. The screened further verified using vitro inhibition assay Caco‐2 cell assay. RESULTS rate was increased 73.40 ± 6.01% 97.23 3.18% digestion assay, suggesting that...
The firmness of grape berries is a critical factor influencing their commercial feasibility and highly valued by both breeders consumers. However, berry complex quantitative trait governed multiple genes, our understanding its genetic regulatory network remains incomplete. To elucidate the mechanisms underlying firmness, this study employed genome-wide association studies (GWAS) to identify potential candidate genes associated with fruit cellulose content explore gene that controls...
Aims To evaluate the plaque composition obtained by virtual histology (VH) IVUS according to clinical presentation and compare those data previously published histopathology data. Methods results VH was performed on 95 de novo significant lesions (>75% stenosis) in 85 patients [28 acute coronary syndrome (ACS) patients, 30 lesions; 57 stable angina pectoris (SAP) 65 lesions]. There were a higher prevalence of positive remodelling (47 vs. 22%, P=0.013), thrombus (20 1.5%, P=0.0037),...
As oxidative stress is involved with inflammation and neovascularization, blocking may be beneficial for reducing inflammation.
Abstract Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at initial stage development. RNA-binding proteins (RBPs) play important roles in progression and treatment through distinct functions. However, functions mechanisms RNA binding regulating remain elusive. Here we reported protein RBM4 contributed to cellular senescence. Depletion induced different types cells, including multiple cells....
ABSTRACT Atherosclerosis is a complex disease affecting arterial blood vessels and flow that could result in variety of life-threatening consequences. Disease models with diverged genomes are necessary for understanding the genetic architecture this disease. Non-obese diabetic (NOD) mice highly polymorphic widely used studies type 1 diabetes autoimmunity. Understanding atherosclerosis development NOD strain particular interest as human on autoimmune background has not been successfully...
Tuberculosis ( TB ), caused by Mycobacterium tuberculosis , is one of the most devastating human diseases, and responsible for ~ 2 million deaths worldwide each year. The nutritional requirements growth mycobacteria have been extensively studied since discovery M. but essential nutrients inside host identity corresponding transporters remain unknown. Ugp ABCE transporter five putative permeases carbohydrate uptake, genetically predicted to be an sn ‐glycerol 3‐phosphate importer. We...
During foam cell formation and atherosclerosis development, the scavenger receptor CD36 plays critical roles in lipid uptake triggering of atherogenicity via activation Vav molecules. The family includes three highly conserved members known as Vav1, Vav2, Vav3. As Vav1 Vav3 were found to exert function it remains thus decipher whether Vav2 also a role development atherosclerosis. In this study we that deficiency RAW264.7 macrophages significantly diminished oxidized LDL signaling,...
Abstract To assess the repeatability and reproducibility of AL-Scan in agreement with those by IOLMaster healthy children, two skilled operators measured ocular parameters 58 children. The included keratometry (K) values, anterior chamber depth (ACD), axial length (AL), central corneal thickness (CCT), pupil diameter (PD), (CD). cohort comprised 32 boys 26 girls. measurements showed high repeatability, as test-retest (TRT) values AL, CCT, ACD, Kf, Ks, Km, CD, PD were 0.09 mm, 5.1 μm, 0.04...
The Sb–Te–Se ternary system with suitable composition material Sb 44 Te 11 Se 45 is proposed for its brilliant thermal stability, which was fabricated by doping 2 3 to Te. Compared the traditional Ge 5 , film exhibits a higher crystallization temperature of 220 °C, larger active energy 4.25 eV, along ultra‐long data retention 133.8 °C 10 years, means stability. It found that could decrease grain size, makes more stable phase‐change memory (PCM) application. For PCM cell based on resistance...