A5081747781- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Cardiac Ischemia and Reperfusion
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Attention Deficit Hyperactivity Disorder
- Calpain Protease Function and Regulation
- Traumatic Brain Injury Research
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Wnt/β-catenin signaling in development and cancer
Children's Hospital of Zhejiang University
2015-2024
Zhejiang University
2007-2024
National Clinical Research
2024
Indiana University – Purdue University Indianapolis
2014-2017
Indiana University School of Medicine
2014-2017
Stanford University
2010-2011
Neurology, Inc
2011
Boston Children's Hospital
2004
Cell transplantation offers a novel therapeutic strategy for stroke; however, how transplanted cells function in vivo is poorly understood. We show the first time that after subacute into ischemic brain of human central nervous system stem grown as neurospheres (hCNS-SCns), cell-secreted factor, vascular endothelial growth factor (hVEGF), necessary cell-induced functional recovery. correlate this recovery to hVEGF-induced effects on host including multiple facets repair and its unexpected...
Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue replace ischemic tissue caused by HI restore function. However, mechanisms which stem cell transplants induce functional recovery are yet be elucidated. In present study, we sought investigate efficacy human neural cells derived from embryonic rat model neonatal enhancing repair.The were genetically engineered...
Central sensitization and network hyperexcitability of the nociceptive system is a basic mechanism neuropathic pain. We hypothesize that development cortical underlying pain may involve homeostatic plasticity in response to lesion-induced somatosensory deprivation activity loss, can be controlled by enhancing activity. In mouse model pain, vivo two-photon imaging patch clamp recording showed initial loss subsequent recovery enhancement spontaneous firings pyramidal neurons. Unilateral...
Introduction Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders mainly representing impaired social communication. The etiology ASD includes genetic and environmental risk factors. Rodent models containing gene mutations or factors, such as exposure to maternal inflammation, show abnormal behavior. Although zebrafish conserves many important brain structures humans has sophisticated fine behaviors in interaction, it unknown whether the their offspring would be due...
Effective treatment and/or prevention strategies for neonatal persistent pulmonary hypertension of the newborn (PPHN) have been an important topic in medicine. However, mechanisms impaired vascular structure hypoxia-induced PPHN are poorly understood and consequently limit development effective treatment. In this study, we aimed to explore molecular signaling cascades lungs a animal model used primary cultured rat microvascular endothelial cells analyze physiological benefits ghrelin during...
A variety of major developmental cortical malformations are closely associated with clinically intractable epilepsy. Pathophysiological aspects one such disorder, human polymicrogyria, can be modeled by making neocortical freeze lesions (FL) in neonatal rodents, resulting the formation microgyri. Previous studies showed enhanced excitatory and inhibitory synaptic transmission connectivity layer V pyramidal neurons paramicrogyral cortex. In young adult transgenic mice that express green...
The molecular mediators underlying the effects of inflammation on neural stem cells (NSCs) are not fully characterized. In this study, we identified Ascl2 as a downstream basic helix-loop-helix (bHLH) transcription factor in NSCs following exposure to TNFα. Under normal conditions, expression is inhibited at post-transcriptional levels by miR-26a, which targets 3' untranslated region (UTR) Ascl2. Upon TNFα, miR-26a reduced, leads up-regulation Overexpression promotes neuronal...
Anxiety is a common emotional disorder in children. To understand its underlying mechanisms, chronic unpredictable stress (CUS) has been established as model zebrafish. By using the tall tank test, response reliability could be improved adult fish which not confirmed larvae. In addition, increasing evidences have shown that cerebellum plays important roles anxiety. Whether CUS will affect cerebellar neuronal activity remains unknown. We found exposure to larvae (from 10 17 days post...
Astrocytes form extensive intercellular networks through gap junctions to support both biochemical and electrical coupling between adjacent cells. ATP-sensitive K+ (KATP) channels couple cell metabolic state membrane excitability are enriched in glial Activation of astrocytic mitochondrial KATP (mitoKATP) channel regulates certain functions. However, less is known about its impact on directly coupled astrocytes ex vivo. By using dual patch clamp recording, we found that activation mitoKATP...
The initial pathological changes of diffuse axonal injury following traumatic brain (TBI) include membrane disruption and loss ionic homeostasis, which further lead to dysfunction conduction axon disconnection. Resealing the axolemma is therefore a potential therapeutic strategy for early treatment TBI. Monomethoxy poly (ethylene glycol)-poly (D, L-lactic acid) di-block copolymer micelles (mPEG-PDLLA) have been shown restore depressed compound action potentials (CAPs) spinal axons promote...
The present study was designed to set up a reliable model of severe hypoxia‑ischemia brain damage (HIBD) in neonatal rats and several methods were used identify whether the successful. A total 40 healthy 7‑day‑old Sprague‑Dawley randomly divided into 2 groups: sham‑surgery group (n=18) HIBD (n=22). produced according traditional Rice method. anesthetized with ethyl ether. left common carotid artery (CCA) exposed, ligated cut. Following this, exposed hypoxia normobaric chamber filled 8%...
It is known that neuronal ATP-sensitive potassium (KATP) channels and astrocytic gap junctions (GJs) are involved in the mechanism underlying neurodisorders. The KATP exist also glial cells, objective of this study was to determine whether exert their effect on neurotoxin-induced neurodysfunction through regulating GJ function. results showed diazoxide, a selective mitochondrial (mitoKATP) channel opener, enhanced coupling, but 5-hydroxydecanoate, mitoKATP blocker significantly inhibits...
To establish a clinical prediction rule for acute bilirubin encephalopathy (ABE) in term/near-term neonates with extreme hyperbilirubinemia.A retrospective cohort study was conducted between January 2015 and December 2018. Six hundred seventy-three out of 26,369 consecutive hyperbilirubinemia were enrolled this study. Data included demographic characteristics, total serum (TSB), albumin, bilirubin/albumin ratio (B/A), direct antiglobulin test, glucose-6-phosphate deficiency, asphyxia,...
Abstract The number of elective day-case surgeries has considerably increased in recent years, especially China. Few studies have investigated the ability mobile applications to assist recovery for patients having undergone day-surgery; however, these indicated that use is cost-efficient and a positive effect on after surgery. This study aimed evaluate utility efficacy using 317-nursing application program (317NAPP) monitoring home following day-surgery involving high ligation hernial sac...
Abstract Background This study aimed to evaluate the efficacy and retention rate of a ketogenic diet (KD) assess factors that influence KD therapy in children with refractory epilepsy (RE). Methods We retrospectively studied 56 RE who accepted from January 2013 December 2019. Patients had ≥50% reduction seizure frequency were defined as responders. The was calculated proportion continued KD/the total number followed up at time enrollment. also analyzed effects different (such gender, initial...