A5059544054- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Genetic Syndromes and Imprinting
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Colorectal Cancer Treatments and Studies
- interferon and immune responses
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Luminescence and Fluorescent Materials
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Congenital Diaphragmatic Hernia Studies
- Signaling Pathways in Disease
- Advanced Polymer Synthesis and Characterization
- Mycobacterium research and diagnosis
Nanjing Medical University
2014-2024
Fudan University
2024
Hebei Medical University
2023
University of Bristol
2020-2023
Third Hospital of Hebei Medical University
2023
Southeast University
2022
Southeast University
2020
University of California, Davis
2020
Xijing Hospital
2020
Air Force Medical University
2018
Inflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy various cancers. The aim of this study is investigate significance pre-operative neutrophil lymphocyte ratio (NLR), derived (dNLR), platelet (PLR) monocyte (LMR) gastric cancer (GC).389 patients who had undergone gastrectomy were enrolled from 2007 2009 study. NLR, dNLR, PLR LMR calculated peripheral...
Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, immunosuppressive factors induced radiation on tumor cells remain to identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast (BC) and RT-treated mouse syngeneic BC. Co-expression both receptors more frequently detected recurrent BC patients poor prognosis. CD47 preferentially HER2-expressing cells, blocking or reduces...
Exosomes mediated transfer of lncRNA 91H may play a critical role in the development CRC. However, few studies have proved mechanism. So we performed this study to deeply explore biological functions exosomal and progression CRC.The association between exosomes was detected vitro vivo. Then RNA pulldown RIP were used detect how affect CRC IGF2 express. At last, clinic pathological significance evaluated by Cox proportional hazards model.We found that serum expression closely related cancer...
// Pian Liu 1 , Shao-Hua Xie 2 Shaobo Hu 3 Xiang Cheng Tianyi Gao 4 Chen Zhang and Zifang Song Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan 430022, China Department Molecular Medicine Surgery, Karolinska Institutet, Stockholm 17176, Sweden Hepatobiliary The First Clinical School, Correspondence to: Zhang, email: zhang_chen@hust.edu.cn Keywords: hepatocellular carcinoma, liver cancer, sex difference, incidence, estrogen Received:...
Abstract Background A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization is widespread on whole world. The acute respiratory syndrome 2 (SARS-CoV-2) was proved to be main agent COVID-19. In present study, we conducted an in depth analysis SARS-COV-2 nucleocapsid identify potential targets that may allow identification therapeutic targets. Methods N protein subcellular localization and physicochemical property analyzed PSORT II Prediction...
Background Long noncoding RNAs (lncRNAs) play widespread roles in gene regulation and cellular processes. However, the functional of lncRNAs colorectal cancer (CRC) are not yet well elucidated. The aim present study was to measure levels lncRNA 91H expression CRC evaluate its clinical significance biological development progression CRC. Methods copy number variation (CNV) were measured 72 tumor tissues adjacent normal by real-time PCR. evaluated MTT, scratch wound assay, migration invasion...
Hepatocellular carcinoma (HCC), one of the most aggressive malignancies, ranks as fourth leading cause cancer-related deaths worldwide. Emerging evidence indicates that RNA N6-methyladenosine (m6A) plays a critical role in tumor progression. However, biological function YTHDF1 HCC remains unclear. Here, we found expression was strikingly elevated tissues and cell lines significantly associated with prognosis patients. Moreover, transcriptionally regulated by USF1 c-MYC HCC. Functional...
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) METTL14 are two core molecules. However, METTL3 play opposite regulatory roles in hepatocellular carcinoma (HCC). Based on The Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) database, we conducted multi-omics analysis HCC, including RNA-sequencing,...
Long non‐coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. 91H, novel long noncoding antisense transcripts located on the position H19/IGF2 locus has suggested to play potential tumor‐suppressor role tumor development. However, little study proved mechanism esophageal squamous cell carcinoma (ESCC). We carried out this explore lncRNA 91H regulation H19 imprinting control regions (ICR) and IGF2 expression association between ESCC...
Polymorphisms in microRNA (miRNA) have been discussed to be associated with breast cancer risk; however, the conclusions were always inconsistent different ethnicities. This case–control study enrolled 450 cases, and health controls was carried out investigate association between six polymorphisms miRNAs risk. Sequenom MassARRAY used detect miRNAs, immunohistochemistry assay applied expression of estrogen receptor (ER) progesterone (PR) tissue. The data showed that 3746444 GG increased risk...
MicroRNA-21 (miR-21) has been ascribed a key role in many cellular processes, e.g. tumorigenesis via inhibition of target gene expression. However, its diffuse large B-cell lymphoma (DLBCL) is still unclear, and there are no in-depth studies on the relationship between miR-21 phenotype DLBCL. In this study, we investigated expression regulation cell biological processes Firstly, was evaluated three DLBCL lines by real-time quantitative reverse-transcription (qRT) polymerase chain reaction...
Background: Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms the lncRNA PRNCR1, PCAT1, and CCAT2 transcribed from locus a potential risk for Methods: To evaluate whether there is such an Chinese population, case-control study enrolled 494 patients healthy controls was carried out. Sequenom MassARRAY platform used genotyping. Results: This showed rs16901946 G allele associated with increased of cancer (AG:...
Polymorphisms in nucleotide excision repair (NER) pathway genes are associated with the risk of breast cancer, but relevance these associations appeared to vary according ethnicity subjects. To systemically evaluate potential between NER polymorphisms and cancer a Chinese population, we carried out case-control study on 450 patients 430 healthy controls. Sequenom MassARRAY was used for genotyping, immunohistochemistry performed detect estrogen receptor (ER), progesterone (PR), human...
We, the Editors and Publisher of journal Artificial Cells, Nanomedicine, Biotechnology, have retracted following article:Tianyi Gao, Xiangxiang Liu, Bangshun He, Yuqin Pan & Shukui Wang (2020) Long non-coding RNA 91H regulates IGF2 expression by interacting with IGF2BP2 promotes tumorigenesis in colorectal cancer, 48:1, 664-671, DOI: 10.1080/21691401.2020.1727491Since publication, authors noticed duplication Figure 1A 4A. As this error directly impacts reported results conclusions alerted...
Abstract Purpose The objective of this study was to investigate the efficacy an artificial intelligence-assisted 3D planning system (AIHIP) in total hip arthroplasty by direct anterior approach and assess reliability AIHIP preoperative program terms both interobserver intraobserver agreement. Methods A retrospective analysis conducted on patients who underwent unilateral primary THA via from June 2019 March 2022. Participants were randomly assigned receive either ( n = 220) or 2D template...