A5043882241- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Coronary Interventions and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Viral Infections and Vectors
- Hedgehog Signaling Pathway Studies
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Cardiac Imaging and Diagnostics
- interferon and immune responses
- Virus-based gene therapy research
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- MXene and MAX Phase Materials
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Diseases and Mycology
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Second Hospital of Tianjin Medical University
2025
Tianjin Medical University
2025
Shanghai Jiao Tong University
2021-2023
Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T therapy treatment other solid tumors has been limited. We incorporated 4-1BB into anti-GD2 to test their cytotoxicity melanoma vitro and vivo. Moreover, we reported expression ganglioside GD2 non-Caucasian populations for first time, thus providing a basis future research. This study included tumor samples from 288 at Peking...
Purpose: Effective therapies for the majority of metastatic acral melanoma patients have not been established. Thus, we investigated genetic aberrations CDK4 pathway in and evaluated efficacy CDK4/6 inhibitors targeted therapy melanoma.Experimental Design: A total 514 primary samples were examined copy number variations (CNV) pathway-related genes, including Cdk4, Ccnd1, P16INK4a , by QuantiGenePlex DNA Assay. The sensitivity established cell lines patient-derived xenograft (PDX) containing...
Mucosal melanoma (MM) is the second most common subtype in Asian populations. Deregulation of microRNAs (miRNAs) has been extensively investigated various cancers, including cutaneous melanoma. However, roles miRNAs MM are unclear. In this study, we carried out miRNA profiling MM, and clinical biological miR-23a-3p MM. Methods: expression was profiled by microarray analysis. The quantitated qRT-PCR a cohort 117 patients with its prognostic significance evaluated. effect demonstrated both...
Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and the incidence RCC continues to rise worldwide. Although can be treated with surgery at an early stages, five-year survival rates have been observed decline dramatically in patients advanced disease. Most cytotoxic or targeted drugs will develop resistance some point during therapy. Thus, it is necessary identify novel therapeutic targets RCC. Here, we found that RANBP2-type C3HC4-type zinc finger-containing 1...
Mucosal melanoma with poor prognosis is a common histopathologic subtype of among Chinese and other Asian peoples. Regulated microRNAs (miRNAs) have been reported as oncogenes or tumour suppressors in melanoma. However, the roles specific miRNAs mucosal remain largely unknown. Here, we aimed to assess biological functions, molecular mechanisms clinical potential miR-let-7b miR-let-7c The expression was determined by quantitative polymerase chain reaction (qPCR). Cutoff scores for expressions...
Atezolizumab plus bevacizumab has shown promising efficacy in advanced mucosal melanoma the multi-centre phase II study. This report updates 3-year survival outcomes and multi-omics analysis to identify potential response biomarkers.
High-dose interferon alfa-2b (IFN-α-2b) improves the survival of patients with high-risk melanoma. We aimed to identify baseline peripheral blood biomarkers predict outcome acral melanoma treated IFN-α-2b. Pretreatment parameters and clinical data were assessed in 226 Relapse-free (RFS) overall (OS) using Kaplan-Meier method, multivariate Cox regression analyses applied after adjusting for stage, lactate dehydrogenase (LDH), ulceration. Univariate analysis showed that...
B-Raf proto-oncogene serine/threonine kinase (BRAF) V600E is the most common kinase‑activating mutation and associated with poor prognosis in melanoma. However, clinical significance of kinase‑impairing mutations remains unclear. The present study aimed to analyze BRAF codons 594 596 non‑Caucasian patients melanoma investigate their possible significance. To detect hotspot mutations, exon 15 gene was amplified using polymerase chain reaction samples from 1,554 Among these patients, a total...
G2 and S‐phase expressed 1 ( GTSE 1) regulates cell cycle progression in human cancers. However, its significance mechanism of action acral melanoma AM ) remain unknown. In the present study, we found that expression was upregulated advanced stage/metastatic tissues metastatic lines, correlated with higher stage P = .028) poor disease‐free survival DFS patients .003). Cox regression assays validated to be an independent prognostic factor for .004). Ectopic enhanced primary proliferation,...
mTOR is an important therapeutic target in many types of cancers. In melanoma, the nonsynonymous mutation rate up to 10.4%. However, inhibitors have shown limited effects clinical trials melanoma. Because mutations are distributed, not selecting patients with specific may be main reason for failures. Our previous research found that P2213S and S2215Y kinase domains resulted gain-of-function were sensitive inhibitors. The purpose this study was test effect heterozygous/homozygous H2189Y on...
Coexistence of enhancer zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status V600E mutation copy number variation EZH2 potential combination as a therapeutic target. A total 138 cases melanoma samples harboring were included, numbers examined by QuantiGenePlex DNA Assays. Clinical pathological distinction between patient groups with or without amplification (hereafter referred gain) was statistically...
Asian populations are more likely to develop acral melanoma (AM) than Caucasians. The high-dose interferon (HD-IFN) α-2b regimen is the main adjuvant treatment for AM. TERT encodes catalytic subunit of telomerase reverse transcriptase, which plays an important role in melanoma. Frequent mutation and increased gene expression have been described Our study aimed investigate status clinical significance copy number a large cohort patients with AM analyze relationship between gain efficiency...
Introduction: Cyclic plaque structural stress has been hypothesized as a mechanism for fatigue and eventually rupture. A novel approach to derive cyclic in vivo from optical coherence tomography (OCT) is hereby developed. Materials Methods: All intermediate lesions previous OCT study were enrolled. cross-sections at representative positions within each lesion selected analysis. Detailed morphology, including composition, lumen internal elastic lamina contours, automatically delineated....
The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment BRAF inhibitors. Mutation‑specific 3D digital polymerase chain reaction (dPCR) was used quantify BRAFV600E circulating tumor DNA (ctDNA) 58 prior Correlations between baseline ctDNA levels clinicopathological characteristics clinical benefits were then statistically analyzed. concordance sensitivity...
Purpose: Polymorphisms of genes in the platelet-derived growth factor (PDGF) signaling pathway have been found to predict cutaneous melanoma (CM) survival, but their clinical effects acral (AM) patients not explored. The aim this study was characterize functional effect tag single-nucleotide polymorphism (SNP) rs2228230:C>T and assess its association with outcomes AM patients. Methods: on mRNA structures codon usage values were evaluated using silico analyses. PDGF receptor alpha (PDGFRA)...
Background/objective: Uveal melanoma (UM) is the most common intraocular malignancy and has a high tendency to metastasize liver. Although primary tumours can be successfully treated, there currently no effective treatment for metastatic UM. To gain insight into genetics of UM, we performed targeted next-generation sequencing (NGS) UM samples from non-Caucasian population. Methods: This study included tumour blood 107 patients at Peking University Cancer Hospital & Institute. Clinical data...
Background: AURKA kinase is an essential serine/threonine for mitosis and chromosome stability.The aberrant amplification overexpression of are commonly observed in various types cancer, including cutaneous melanoma.However, the status clinical significance copy number (CN) acral melanoma (AM) have not been fully elucidated.Methods: Four hundred seventy-two AM samples were included study.AURKA CN was examined using QuantiGenePlex DNA Assay.We analysed relationship to clinicopathological...
Neuroblastoma rat-sarcoma viral oncogene homolog (NRAS) isoforms are expressed in melanoma tumor tissues, which have been described Caucasian melanoma. However, the status and clinical significance of NRAS Asian population not investigated on a large scale. We examined expression levels 140 samples using quantitative real-time PCR. Furthermore, relationship mRNA to clinicopathological characteristics survival patients was analyzed. Statistical analysis showed that isoform 2 correlated with...
Patient-derived xenograft (PDX) models mostly retain the histological and genetic features of their donor tumors, which have been used for investigating various types cancer. However, PDX melanoma, especially acral are reported occasionally. We aimed to establish a large panel melanoma representing predominant Asian melanomas. Ninety-three fresh samples were implanted subcutaneously into nonobese diabetic/severe combined immunodeficiency mice. The characteristics analyzed in both patient...