A5032103127- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Medical and Biological Sciences
- Ultrasound Imaging and Elastography
- Memory and Neural Mechanisms
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Quantum Dots Synthesis And Properties
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cannabis and Cannabinoid Research
- Antioxidant Activity and Oxidative Stress
- Pomegranate: compositions and health benefits
- Prenatal Substance Exposure Effects
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Medical Image Segmentation Techniques
- Nerve injury and regeneration
- Photoacoustic and Ultrasonic Imaging
- Nuclear Physics and Applications
- Neuroscience and Neuropharmacology Research
Cedars-Sinai Medical Center
2015-2025
National Institute of Mental Health
2024
National Institutes of Health
2024
Johns Hopkins University
2024
National Institute of Neurological Disorders and Stroke
2024
University of Pennsylvania
2024
California Hospital Medical Center Foundation
2020
Sinai Health System
2020
University of California, Los Angeles
2011-2013
Human Longevity (United States)
2013
Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and diet as a precursor neurological health, rigorous studies investigating cognitive effects foods their components are rare. Recent animal have reported other benefits polyphenols, found abundantly pomegranate juice. We performed preliminary, placebo-controlled randomized trial juice older subjects with age-associated complaints using testing functional brain activation (fMRI) outcome measures....
ABSTRACT Background and Purpose The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* combined MRI contrast that provides high conspicuity CVS at 3 Tesla (3T), enabling its sensitive accurate detection in clinical settings. This study evaluated whether of 3T reliable across sites vendors gadolinium (Gd) increases conspicuity. Methods A cross‐sectional, multicenter recruited adults referred possible diagnosis MS 10 sites. was generated using...
Identifying subjects with mild cognitive impairment (MCI) most likely to decline in cognition over time is a major focus Alzheimer′s disease (AD) research. Neuroimaging biomarkers that predict would have great potential for increasing the efficacy of early intervention. In this study, we used high‐resolution MRI, combined cortical unfolding technique increase visibility convoluted medial temporal lobe (MTL), assess whether gray matter thickness MCI correlated two years. We found entorhinal...
The central vein sign (CVS) is a proposed diagnostic imaging biomarker for multiple sclerosis (MS). proportion of white matter lesions exhibiting the CVS (CVS+) higher in patients with MS compared to its radiological mimics. Evaluation CVS+ prior studies have been performed by manual rating, an approach that time-consuming and has variable inter-rater reliability. Accurate automated methods would facilitate efficient assessment CVS. objective this study was compare performance detection...
Motivation: To restore image quality of highly accelerated QSM for data interpretation. Goal(s): evaluate the feasibility a denoising convolutional neural network generating high-quality submillimeter isotropic acquired in 2-3 minutes at 3-Tesla. Approach: A previously developed complex-valued MRI was applied to 3D-EPI scans (TA: 2min and 3min). Image evaluated values obtained with without were compared against reference non-accelerated non-denoised 6min). Results: SNR structural measures...
Motivation: Quantitative susceptibility mapping (QSM) enables in vivo detection of chronic active brain lesions Multiple Sclerosis (MS) due the presence iron-laden lesion borders also called Paramagnetic Rim Lesions (PRL). Goal(s): To evaluate feasibility generating submillimeter isotropic resolution QSM using 3D-EPI for precise quantification PRL MS patients. Approach: Separate masks rim and core were generated. Results: Submillimeter reduces partial volume averaging effect measurement PRL+...
Motivation: Conventional gradient echo SWI has a slow acquisition speed, thus limiting the minimal scan time achievable. However, accelerated 3D-EPI sequence can perform fast MR acquisition. Goal(s): In this study, we evaluated feasibility of SWI-EPI to generate ultra-fast susceptibility weighted images. Approach: combines 3D (muti-shot) EPI with CAIPIRINHA acceleration significantly reduce time. Results: A significant reduction in (up 70%) was achieved similar image quality and without any...
High-resolution T2*-weighted brain imaging using 3D echo planar (3D-EPI) at 3T allows detection of new biomarkers neurological disorders, such as the central vein sign in multiple sclerosis. However, current 3D-EPI scan times are suboptimal for a widespread implementation hospitals and private centers. In this study, we evaluated feasibility combining acquisition with different CAIPIRINHA undersampling patterns. A significant reduction time (up to 70% reduction) was achieved without any...
The scan time of high-resolution T2*-weighted brain imaging using 3D echo-planar (3D-EPI) can be significantly reduced by applying Controlled Aliasing In Parallel Imaging Results Higher Acceleration (CAIPIRINHA). However, this comes at the expense a significant reduction in image quality. study, we evaluated feasibility deep learning-based approach (DnCNN) to denoise highly accelerated 3D-EPI scans acquired 3T. Our results show that DnCNN was able efficiently while preserving anatomical and...
Abstract A case of antibody proven Guillain Barré Syndrome in a previously healthy young female with extra clinical features, scans, and physical exam findings consistent cervical spine medullary junction myelitis, together new variant to consider.
OBJECTIVE: To determine the imaging and cognitive consequences of comorbid depression in multiple sclerosis BACKGROUND: Depression is a common comorbidity sclerosis (MS) impacting quality life, employment status performance. Selective subregional hippocampal atrophy, alterations diurnal cortisol secretion patterns impairment have been reported MS patients with depressive symptoms, similar to idiopathic major disorder (MDD). However, relationship (MSD) MDD has not established. We performed...
<h3>Objective:</h3> To evaluate sympathetic nervous system (SNS) activity in subjects with REM sleep behavior disorder (RBD) at risk of Parkinson's disease, using imaging and autonomic functions markers. <h3>Background:</h3> While the nature RBD is not completely understood, there evidence that enhancement noradrenergic may play a causative role, as suggested by persistent tonic discharge locus coeruleus (LC) RBD-triggering action selective norepinephrine reuptake inhibitors....