A5086370997- Plant and animal studies
- Fossil Insects in Amber
- Hymenoptera taxonomy and phylogeny
- Insect and Arachnid Ecology and Behavior
- Multiple Sclerosis Research Studies
- Plant Parasitism and Resistance
- Retinal Diseases and Treatments
- Insect and Pesticide Research
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Marine and environmental studies
- Retinal Imaging and Analysis
- Geological Studies and Exploration
- Neuroinflammation and Neurodegeneration Mechanisms
- Fern and Epiphyte Biology
- Retinal Development and Disorders
- Vector-borne infectious diseases
- Amyotrophic Lateral Sclerosis Research
- Food Industry and Aquatic Biology
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Neuropathies and Disorders
- Lepidoptera: Biology and Taxonomy
- Systemic Lupus Erythematosus Research
- Coleoptera Taxonomy and Distribution
- Geriatric Care and Nursing Homes
University of California, San Francisco
2018-2024
Universidad Católica de Santa Fe
2022-2024
Johns Hopkins Medicine
2018-2022
Johns Hopkins University
2018-2022
University of California, San Diego
2022
University of Maryland, Baltimore
2022
University of Maryland, College Park
2022
University of Verona
2022
Center for Neurosciences
2021-2022
College of Charleston
2022
While neurodegeneration underlies the pathological basis for permanent disability in multiple sclerosis (MS), predictive biomarkers progression are lacking. Using an animal model of chronic MS, we find that synaptic injury precedes neuronal loss and identify thinning inner plexiform layer (IPL) as early feature inflammatory demyelination—prior to symptom onset. As domains anatomically segregated retina can be monitored longitudinally, hypothesize IPL could represent a biomarker MS....
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed the Code has already been discussed Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; 2009a-b; Dubois Gentile Snell Minelli Cianferoni Bartolozzi 2016; Amorim et al. 2016). This was again raised a letter supported 35 signatories published journal Nature (Pape 2016) on 15 September 2016. On 25 2016,...
Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel activated by painful stimuli such as capsaicin and noxious heat, enriched in sensory neurons of the pain pathway. During inflammation, chemical mediators activate protein kinases (such PKC) that phosphorylate TRPV1 thereby enhance its function, with consequent increases nociceptor sensitization. However, causal relationships between phosphorylation pathological remain unexplored. To directly...
To implement a technology-based, systemwide readmission reduction initiative in safety-net health system and evaluate clinical, care equity, financial outcomes. Retrospective interrupted time series analysis between October 2015 January 2023. The standardized inpatient for patients through novel, electronic record-integrated, digitally automated point-of-care decision-support tool. A predictive artificial intelligence algorithm was utilized to identify at the highest risk of both outpatient...
Abstract Aim Based on seven consecutive seasons of biotic survey and inventory the terrestrial freshwater plants animals 30 major islands Kuril Archipelago, a description biodiversity an analysis biogeography this previously little known part world are provided. Location The natural laboratory for investigations into origin, subsequent evolution, long‐term maintenance insular populations, forms eastern boundary Okhotsk Sea, extending 1200 km between Hokkaido, Japan, Kamchatka Peninsula...
<h3>Background and Objectives</h3> The timing of neurodegeneration in multiple sclerosis (MS) remains unclear. It is critical to understand the dynamics neuroaxonal loss if we hope prevent or forestall permanent disability MS. We therefore used a deeply phenotyped longitudinal cohort assess compare rates retina brain throughout MS disease course. <h3>Methods</h3> analyzed 597 patients with who underwent optical coherence tomography imaging annually for 4.5 ± 2.4 years 432 MRI scans 10 3.4...
Transportation access is a social determinant of health that hinders chronic care engagement for vulnerable populations. Few studies have examined how transportation interventions impact healthcare outcomes when implemented independently other tailored (i.e., multicomponent outreach programs). Data further limited rideshare initiatives. We conducted retrospective, descriptive analysis rideshare-based program pre- and post-operative patients as part quality improvement (QI) initiative at San...
Abstract Introduction Apolipoprotein E ( APOE ) ε4, the strongest non‐Mendelian genetic risk factor for Alzheimer's disease (AD), has been shown to affect brain capillaries in mice, with potential implications AD‐related neurodegenerative disease. However, human cannot be directly visualized vivo. We therefore used retinal imaging test ε4 effects on central nervous system capillaries. Methods collected optical coherence tomography angiography, cognitive testing, and research participants...
A description of a new genus and species braconid, Archephedrus stolamissus, from Early Cretaceous (Albian) amber Moraza-Peñacerrada I (Spain) is here provided. This the first fossil Aphidiinae described in amber. The has some typical characters subfamily but possesses unique assemblage among aphidiines, such as fairly robust abdomen, with more pronounced articulation between second, instead second third, metasomal segments, well several wing venational traits. distribution this other...
Most genetically distinct inherited retinal degenerations are primary photoreceptor degenerations. We selected a severe early onset form of Leber congenital amaurosis (LCA), caused by mutations in the gene LCA5, order to test efficacy augmentation therapy for ciliopathy. The LCA5-encoded protein, Lebercilin, is essential trafficking proteins and vesicles outer segment. Using AAV serotype AAV7m8 deliver human LCA5 cDNA into an Lca5 null mouse model we show partial rescue structure visual...
MS is an inflammatory and neurodegenerative disease of the CNS (including retina) that leads to progressive neurologic disability. Disability correlates with degree axonal pathology in disease.1,2 The clinical course unpredictable, making search for biomarkers associated enhanced risk progression a major unmet need. Spectral domain optical coherence tomography (SD-OCT) potential predictor disability worsening up 5 years follow-up after single evaluation peripapillary retinal nerve fiber...
Organisms experience stressors, and the physiological response to these stressors is highly conserved. Acute stress activates both sympathetic nervous system hypothalamic-pituitary-adrenal axis, increasing epinephrine, norepinephrine, glucocorticoids, collectively promoting glucose mobilization. While this well characterized in mammals, hyperglycemic avian nonavian reptiles has received less attention. A number of factors, ranging from time day blood loss, are reported influence extent which...
A new, extinct species of the wasp genus Lindenius (Crabroninae: Crabronini: Crabronina) is described and figured from two exquisitely preserved specimens discovered in Early Miocene Dominican amber. paleomystax, new species, represents first record for tribe Crabronini amber southernmost New World. The unique locality habitat data begin to reveal a more complicated natural history than that suggested by Recent taxa alone. checklist fossil apoid wasps provided discussed within context an...
A primitive wasp of the family Sapygidae is described and figured from a male preserved in mid-Cretaceous (latest Albian, ca. 100 Ma) amber Myanmar. The fossil as new genus species, Cretosapyga resinicola, subfamily, Cretosapyginae, proposed. phylogenetic placement discussed. Cre- tosapyga oldest first formally for lineage, only other rec- ord being putative species Sapyga (Sapyginae) Baltic (Eocene: Lutetian, 45 Ma).
No single neuroimaging technique or sequence is capable of reflecting the functional deficits manifest in MS. Given interest imaging biomarkers for short- to medium-term studies, we aimed assess which metrics might best represent impairment monitoring clinical trials. complexity MS, however, it useful isolate a particular functionally relevant pathway understand relationship between and neurological function. We therefore analyzed existing data, combining multiparametric MRI OCT describe MS...
A new genus and species of the peculiar braconid wasp subfamily Masoninae is described figured from a female preserved in Early Miocene (Burdigalian) amber Dominican Republic. Anoblepsis konokeraia Engel Bennett, species, belongs to tribe Masonini but differs hitherto only known genus, Masona van Achterberg. The diagnosed compared with its modern counterparts. third documented second Masoninae.
The first tiphiid wasp (Aculeata: Euaculeata: Vespoidea: Tiphiiformes) in Cretaceous amber is described and figured. Thanatotiphia nyx, new genus species, represented by a male entombed mid-Cretaceous (latest Albian) from Myanmar. possesses remarkable apomorphies wing venation, lacks key traits of modern subfamilies, thus classified subfamily, Thanatotiphiinae. fossil further shown to be nested well within the family, indicating that major lineages Tiphiidae diverged mid-Cretaceous. taxon...
Two new species of New World halictine bees (Halictidae: Halictinae) are described and figured with extreme forms female macrocephalism. Lasioglossum (Evylaeus) xitle sp. nov. (Halictini: Gastrohalictina) from Cráter del Xitle in Mexico City, Augochlora (Oxystoglossella) empusa (Augochlorini: Augochlorina) Madre de Dios, Peru remarkable for not only their greatly enlarged heads monstrously developed mandibles, but also pronotal modifications (both species), propodeal lamellae (A. empusa),...
A new genus and species of pemphredonine wasp is described figured in Late Cretaceous (Cenomanian to Santonian) amber from Vendée, northwestern France.Menopsila dupeae n. gen.and sp., based on a partial male preserved small sliver translucent amber.The placed incertae sedis within the Pemphredonini, as it intermingles features, likely plesiomorphies, various lineages tribe.It represents stem group one or more constituent subtribes, yet arguably most similar Spilomenina.
Purpose: The purpose of this study was to characterize the benign biological variance fixational microsaccades in a control population using tracking scanning laser ophthalmoscope (TSLO), accounting for machine accuracy and precision, determine ideal testing conditions detect pathologic change eye motion (FEM). Methods: We quantified precision TSLO, analyzing measurements made by three operators on model eye. Repeated, 10-second retinal traces were then recorded 17 controls, 3 times day...