A5042514167- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Aortic aneurysm repair treatments
- Liver Disease Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Advanced X-ray Imaging Techniques
- Photoacoustic and Ultrasonic Imaging
- Elasticity and Material Modeling
- NMR spectroscopy and applications
- Anatomy and Medical Technology
- Multiple Sclerosis Research Studies
- Advanced NMR Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
Pontificia Universidad Católica de Chile
2016-2025
Monash University
2023-2025
Millennium Science Initiative
2018-2023
Millennium Institute for Integrative Biology
2022-2023
Primary Health Care
2023
Millennium Institute for Research in Depression and Personality
2021-2022
Agencia Nacional de Investigación y Desarrollo
2021
Tecnológico de Monterrey
2021
King's College London
2007-2020
Millenium Nucleus for Planet Formation
2020
To evaluate the impact of 3D printed models (3D models) on surgical planning in complex congenital heart disease (CHD).A prospective case-crossover study involving 10 international centres and 40 patients with CHD (median age 3 years, range 1 month-34 years) was conducted. Magnetic resonance imaging computed tomography were used to acquire segment cardiovascular anatomy. Models fabricated by fused deposition modelling polyurethane filament, dimensions compared medical images. Decisions after...
Abstract Four‐dimensional (4D) flow imaging has been used to study patterns and pathophysiology, usually focused on specific thoracic vessels cardiac chambers. Whole‐heart 4D at high measurement accuracy covering the entire cardiovascular system would be desirable simplify improve hemodynamic assessment. This a challenge because compensation of respiratory motion is difficult achieve, but it paramount limit artifacts accuracy. In this work we propose self‐gating technique for...
Objectives To evaluate whether three‐dimensional (3D) printed models can be used to improve interventional simulation and planning in patients with aortic arch hypoplasia. Background : Stenting of a hypoplastic transverse is technically challenging, complications such as stent migration partial obstruction the origin head neck vessels are highly dependent on operator skills expertise. Methods Using magnetic resonance imaging (MRI) data, 3D model repaired coarctation 15‐year‐old boy was...
Abstract Purpose: To explore the use of three-dimensional patient-specific cardiovascular models using rapid prototyping techniques (fused deposition modelling) to improve surgical planning in patients with complex congenital heart disease. Description: Rapid are used print accurate replicas patients' anatomy based on magnetic resonance images computer-aided design systems. Models printed a translucent polylactic acid polymer. Evaluation: As proof concept, model 1.5-year-old boy...
Multiple Sclerosis patients' clinical symptoms do not correlate strongly with structural assessment done traditional magnetic resonance images. However, its diagnosis and evaluation of the disease's progression are based on a combination this imaging analysis complemented examination. Therefore, other biomarkers necessary to better understand disease. In paper, we capitalize machine learning techniques classify relapsing-remitting multiple sclerosis patients healthy volunteers techniques,...
Abstract Two‐dimensional (2D) breath‐hold cine MRI is used to assess cardiac anatomy and function. However, this technique requires cooperation from the patient, in some cases scan planning complicated. Isotropic nonangulated three‐dimensional (3D) MR can overcome of these problems because it minimal be reformatted any plane. current methods, even those that use undersampling techniques, involve breath‐holding for periods are too long many patients. Free‐breathing respiratory gating...
Systemic-to-pulmonary collateral flow (SPCF) may constitute a risk factor for increased morbidity and mortality in patients with single-ventricle physiology (SV). However, clinical research is limited by the complexity of multi-vessel two-dimensional (2D) cardiovascular magnetic resonance (CMR) measurements. We sought to validate four-dimensional (4D) velocity acquisition sequence concise quantification SPCF distribution SV. 29 SV prospectively underwent CMR (1.5 T) (n = 14 bidirectional...
Abstract OBJECTIVES Current risk assessment strategies in type B aortic dissection are focused on anatomic parameters, although haemodynamic abnormalities that result false lumen (FL) pressurization thought to play a significant role growth. The objective of this study was evaluate blood flow the FL using 4D magnetic resonance imaging (MRI) and identify factors independently predict rate METHODS Patients with descending thoraco-abdominal aorta (n = 18) were enrolled prospective observational...
Chronic type B aortic dissection (TBAD) is associated with poor long-term outcome, and accurate risk stratification tools remain lacking. Pressurization of the false lumen (FL) has been recognized as central in promoting growth. Several surrogate imaging-based metrics have proposed to assess FL hemodynamics; however, their relationship enlarging dimensions remains unclear. We investigated association between growth three cardiovascular magnetic resonance (CMR)-derived pressurization:...
Abstract Purpose To diagnose acute myocardial infarction (MI) with MRI, T 1 ‐weighted and 2 images are required to detect necrosis edema. The calculation of both maps can be relevant for quantitative diagnosis. In this work, we present a simultaneous quantification ‐T relaxation times short‐axis view the heart in single scan. Materials Methods An electrocardiograph (ECG)‐triggered, navigator‐gated, interleaved mapping sequence was implemented values phantoms, healthy volunteers, three...
To use cardiac MRI techniques to assess ventricular function and systemic perfusion in preterm term newborns, compare echocardiographic methods, obtain initial reference data.Observational magnetic resonance imaging study.Neonatal Unit, Queen Charlotte's Chelsea Hospital, London, UK. Patients 108 newborn infants with median birth weight 1627 (580-4140) g, gestation 32 (25-42) weeks.Mean (SD) flow volumes assessed by phase contrast (PC) 28 stable were left output (LVO) 222 (46), right (RVO)...
Purpose To validate the use of particle traces derived from four-dimensional (4D) flow magnetic resonance (MR) imaging to quantify in vivo caval contribution pulmonary arteries (PAs) patients who had been treated with Fontan procedure. Materials and Methods The institutional review boards approved this study, informed consent was obtained. Twelve healthy volunteers 10 circulation were evaluated. trace method consists creating a region interest (ROI) on blood vessel, which is used emit...
Several 2D methods have been proposed to estimate WSS and OSI from PC-MRI, neglecting the longitudinal velocity gradients that typically arise in cardiovascular flow, particularly on vessel geometries whose cross section centerline orientation strongly vary axial direction. Thus, contribution of remains understudied. In this work, we propose a 3D finite-element method for quantification 3D-CINE PC-MRI accounts both in-plane gradients. We demonstrate convergence robustness cylindrical using...
5 Technical Efficacy: Stage J. Magn. Reson. Imaging 2019;50:677-681.
Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, tissue engineering vascular grafts (TEVG) the potential biological and synthetic grafts. We aimed design an in-vitro patient-specific patch based on a hybrid 3D print combined with smooth muscle cells (VSMC) differentiation. Based medical images of 2 months-old girl aortic arch hypoplasia using computational modelling, we evaluated most hemodynamically efficient...
Purpose To decompose the 3D wall shear stress (WSS) vector field into its axial (WSS A ) and circumferential C components using a Laplacian finite element approach. Methods We validated our method with in silico experiments involving different geometries modified Poiseuille flow. computed maps of WSS, WSS , 4D flow MRI data obtained from 10 volunteers patients bicuspid aortic valve (BAV). compared centerline method. The mean value, standard deviation, root mean‐squared error, Wilcoxon signed...