A5089148337- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Epilepsy research and treatment
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Brain Tumor Detection and Classification
- Andrographolide Research and Applications
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Pharmacovigilance and Adverse Drug Reactions
- Olfactory and Sensory Function Studies
- Biosimilars and Bioanalytical Methods
- Effects of Vibration on Health
- CNS Lymphoma Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Protein Tyrosine Phosphatases
Complejo Asistencial Sótero del Río
2015-2025
Pontificia Universidad Católica de Chile
2016-2025
Hospital Clínico de la Universidad Católica
2019-2024
Universitat Autònoma de Barcelona
2014-2016
Real-world studies are needed to expand our knowledge concerning populations underrepresented in clinical trials.
Multiple Sclerosis patients' clinical symptoms do not correlate strongly with structural assessment done traditional magnetic resonance images. However, its diagnosis and evaluation of the disease's progression are based on a combination this imaging analysis complemented examination. Therefore, other biomarkers necessary to better understand disease. In paper, we capitalize machine learning techniques classify relapsing-remitting multiple sclerosis patients healthy volunteers techniques,...
Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. It heterogeneous pathology that can follow different clinical courses, mechanisms underlie progression immune response across MS subtypes remain incompletely understood. Here, we aimed to determine differences in immunological status among subtypes. Blood samples from untreated patients diagnosed with clinically isolated syndrome (CIS) (n = 21), forms 62) [relapsing-remitting (RRMS),...
Background: Pain is a common symptom of multiple sclerosis (MS). The reliability outcome measures for pain and the accuracy screening tools are essential treatment purposes. Objectives: This study investigated test–retest Neuropathic Scale (NPS), Symptom Inventory (NPSI), Brief Inventory-Short Form (BPI-SF), Nordic Musculoskeletal Questionnaire (NMQ), Douleur Neuropathique 4 (DN4), painDETECT, DN4 painDETECT. Methods: 110 persons with MS were included (mean age: 45.35 ± 12.73; Expanded...
The 2024 McDonald Criteria now include the optic nerve as fifth topography for dissemination in space. Optical coherence tomography (OCT) is a valuable biomarker diagnosis, prognosis and monitoring of multiple sclerosis (MS). A panel MS neurologists from 19 centres across 9 Latin American (LATAM) countries discussed OCT use, access, standardized protocols research potential. They found inequities access between private (80%) public healthcare (44%). Only had protocols, 50% which followed...
Andrographis paniculata (A. paniculata), a medicinal plant, has shown anti-inflammatory, neuroprotective and antifibrotic effects in animal models as well clinical efficacy different studies, including an anti-fatigue effect autoimmune diseases such rheumatoid arthritis. In multiple sclerosis (MS), fatigue is rated one of the most common disabling symptoms. present trial, we investigated A. on relapse rate relapsing-remitting MS (RRMS) patients receiving interferon beta. A randomised...
Galectin-8 (Gal-8) is a member of glycan-binding protein family that regulates the immune system, among other functions, and target antibodies in autoimmune disorders. However, its role multiple sclerosis (MS), an inflammatory disease central nervous system (CNS), remains unknown. We study consequences Gal-8 silencing on lymphocyte subpopulations development experimental encephalitis (EAE), to then assess presence clinical meaning anti-Gal-8 MS patients. Lgals8/Lac-Z knock-in mice lacking...
Abstract Background Multiple sclerosis (MS) is a chronic immune mediated disease and the progressive phase appears to have significant neurodegenerative mechanisms. The classification of course MS (PMS) has been re-organized into categories active vs. not inflammatory presence absence gradual progression. Clinical trial experience date in PMS with anti-inflammatory medications shown limited effect. Andrographolide new class agent, that proposed as potential drug for autoimmune disorders,...
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therapeutic challenge in Latin America (LATAM). Despite the heterogeneity of this population, ethnic socioeconomic commonalities exist, epidemiologic studies from region have had a limited geographic population outreach. Identification some aspects entire are lacking.ObjectivesTo determine ethnic, clinical characteristics, utilization tools types therapy for patients with NMOSD American...
Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence its neurobiological mechanisms scarce. Here we recorded electroencephalographic activity twenty relapsing-remitting MS and minimal deficit, 20 healthy control (HC) subjects while they solved a WM task. In spite similar performance, HC group demonstrated both correlation between temporoparietal theta memory load, medial frontal successful performances. did...
Brain volume loss (BVL) is a key outcome in multiple sclerosis (MS) trials. Natalizumab highly effective on inflammation with moderate impact atrophy.To explore BVL patients receiving natalizumab an emphasis grey matter (GM).We performed retrospective post hoc analysis of 38 for 3 years using longitudinal voxel-based morphometry (VBM) and FreeSurfer.Significant was observed during first year: brain parenchymal fraction (BPF): -1.12% ( p < 0.001); white (WMF): -0.9% = (GMF): -1.28% 0.002). GM...
Secondary paroxysmal dyskinesias (SPDs) are short, episodic, and recurrent movement disorders, classically related to multiple sclerosis (MS). Carbamazepine is effective, but with risk of adverse reactions. We identified 7 patients SPD among 457 MS (1.53%). occurred in face ( n = 1), leg 2), or arm +leg 4) several times during the day. Magnetic resonance imaging (MRI) showed new enhancing lesions thalamus mesencephalic tegmentum cerebellar peduncles 5). Patients were treated clonazepam then...
Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed enhance precision by developing SPAMS (SuS, PACNS, MS) score, a practical radiological tool.
Abstract Background and Purpose The diagnostic criteria for myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) were published in 2023. We aimed to determine the performance of new Latin American (LATAM) patients compared with 2018 explore significance MOG–IgG titers diagnosis. Methods retrospectively reviewed medical records LATAM (Argentina, Chile, Brazil, Peru, Ecuador, Colombia) adult one clinical MOGAD event MOG‐IgG positivity confirmed by cell‐based assay....