A5055807322- Metabolism and Genetic Disorders
- Health and Lifestyle Studies
- Celiac Disease Research and Management
- Microscopic Colitis
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Folate and B Vitamins Research
- Mitochondrial Function and Pathology
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Digestive system and related health
- Amino Acid Enzymes and Metabolism
- Clinical Nutrition and Gastroenterology
- Trace Elements in Health
- Cystic Fibrosis Research Advances
- Helicobacter pylori-related gastroenterology studies
- Birth, Development, and Health
- Intestinal Malrotation and Obstruction Disorders
- Heavy Metal Exposure and Toxicity
- Iron Metabolism and Disorders
Hospital Universitario Insular de Gran Canaria
2016-2025
Universidad de Las Palmas de Gran Canaria
2016-2025
Pontificia Universidad Católica de Chile
2014-2025
Instituto de Salud Carlos III
2014-2024
Light Prescriptions Innovators (Spain)
2024
Centro de Investigación Biomédica en Red
2015-2024
Hospital Materno-Infantil
2009-2023
Universidad de Navarra
2021
Universidad Autónoma de Madrid
2021
Madrid Institute for Advanced Studies
2021
Interactions between environmental factors and predisposing genes could be involved in the development of coeliac disease (CD). This study has assessed whether milk-feeding type HLA-genotype influence intestinal microbiota composition infants with a family history CD. The included 164 healthy newborns, at least one first-degree relative CD, classified according to their HLA-DQ genotype by PCR-SSP DQB1 DQA1 typing. Faecal was analysed quantitative PCR 7 days, 1 4 months age. Significant...
La tasa de desnutrición entre los lactantes con cardiopatías congénitas (CC) es elevada. Una evaluación e intervención nutricional tempranas ayudan a su tratamiento y mejoran el pronóstico. El objetivo fue elaborar un documento consenso para la del lactante CC. Se utilizó una técnica Delphi modificada. Con base en literatura experiencia clínica, comité científico elaboró listado afirmaciones que abordaban derivación unidades nutrición pediátrica (UNP), manejo Especialistas cardiología...
More than 10 million Europeans show signs of mild cognitive impairment (MCI), a transitional stage between normal brain aging and dementia memory disorder. The path MCI takes can be divergent; while some maintain stability or even revert to norms, alarmingly, up half the cases progress within 5 years. Current diagnostic practice lacks necessary screening tools identify those at risk progression. European patient experience often involves long journey from initial eventual diagnosis dementia....
The primary objective of this study was to determine the bifidogenic effect galacto-oligosaccharides (GOS) in a follow-on formula and effects on other intestinal bacteria. Secondary objectives were stool characteristics, growth, general well-being.In multicenter, double-blind study, 159 healthy infants, formula-fed at enrollment (at 4-6 months), randomized an experimental supplemented with 5 g/L (77 infants), or standard (control, 82 infants). Infants evaluated (study day 1 = sd1), after 6...
Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness clinical presentation unique biochemical characteristics. In cases arterial or venous thrombotic vascular events, particularly with other comorbidities, it crucial consider moderate severe HHcy. A...
<i>Background:</i> Although adequacy of nutrient intake has been studied considerably in children and adolescents across Europe, the factors associated with nutritional risk have rarely addressed. This study was developed order to explore intakes Spanish influencing inadequacy. <i>Objectives: </i>To evaluate socio-economic lifestyle variables adolescents. <i>Methods:</i> A cross-sectional utilising face-to-face interviews. random sample 3,534 individuals...
The aim of the present study was to elucidate whether a dairy drink enriched with ω-3 long-chain polyunsaturated fatty acid (LC-PUFA) could have an impact on lipid profile mother and newborn, also this intervention affect newborns' visual cognitive development.A total 110 pregnant women were randomly assigned one following groups: control group (n = 54), taking 400 mL/day drink, supplemented (fish oil [FO]) 56), fish oil-enriched (including ∼400 mg eicosapentaenoic acid-docosahexaenoic...
Advances in the diagnosis and treatment of urea cycle disorders (UCDs) have led to a higher survival rate. The purpose this study is describe characteristics patients with Spain.Observational, cross-sectional multicenter study. Clinical, biochemical genetic data were collected from UCDs, treated metabolic diseases centers Spain between February 2012 2013, covering entire Spanish population. Heterozygous mothers OTC deficiency only included if they on due being symptomatic or having...
Abstract This is a prospective, multicenter study of cohort 224 cystic fibrosis (CF) patients treated with CF transmembrane conductance regulator (CFTR) modulators (CFTRm). Our aim was to prospectively analyze the effect CFTRm treatment on fat‐soluble vitamin serum levels. Demographic and clinical data were recorded, levels analyzed at baseline, 6 12 months after starting treatment. Two groups separately: receiving dual therapy lumacaftor/ivacaftor or tezacaftor/ivacaftor (Lum/Tez+Iva),...
Background/Objectives: The present study updates the Spanish registry of patients with urea cycle disorders (UCD), originally established in 2013, to provide comprehensive epidemiological data and evaluate impact therapeutic strategies newborn screening (NBS) on clinical outcomes. Methods: This retrospective, multicenter focuses 255 UCD patients. It includes all living deceased cases up February 2024, analyzing demographic, clinical, biochemical variables. Results: incidence Spain over past...
The 2024 McDonald Criteria now include the optic nerve as fifth topography for dissemination in space. Optical coherence tomography (OCT) is a valuable biomarker diagnosis, prognosis and monitoring of multiple sclerosis (MS). A panel MS neurologists from 19 centres across 9 Latin American (LATAM) countries discussed OCT use, access, standardized protocols research potential. They found inequities access between private (80%) public healthcare (44%). Only had protocols, 50% which followed...
The healthy action of probiotics is not only due to their nutritional properties and influence on the gastrointestinal environment, but also immune system. aim present study was determine if 6 weeks probiotic intake would be able modulate system in women who had recently delivered were breast-feeding. design consisted a randomised, controlled double-blind intervention with parallel groups sample size 104 women. main variable T helper type 1/T 2 (Th1/Th2) profile determined by measuring...
Carnitine-acylcarnitine translocase (CACT) deficiency is a rare autosomal recessive disease in the mitochondrial transport of long-chain fatty acids. Despite early diagnosis and treatment, still has high mortality rate.Clinical symptoms, long-term follow-up, biochemical molecular results four cases are described compared with reviewed literature data 55 cases.Two neonatal onset, carrying homozygosity novel variant sequences p.Gly20Asp (c.59G>A) p.Arg179Gly (c.536A>G), died during an...
A large retrospective multicentre study was conducted in Spain to evaluate the efficiency of new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria diagnosis coeliac disease (CD).The protocol approved by ethics committee Hospital Universitari i Politècnic La Fe (Valencia, Spain). The present included 2177 children (ages 0.6-15.9 years) with small bowel biopsy (SBB) performed diagnostic purposes (from 2000 2009) a minimum 2-year follow-up after...
The aim of this study was to assess the incidence and clinical pattern celiac disease (CD) presently diagnosed in Spanish children.A prospective, multicenter, nationwide registry new cases CD children <15 years conducted from June 1, 2006 May 31, 2007. parameters studied were age at diagnosis, sex, symptoms, associated diseases, nutritional status, serology, histological lesions, HLA-DQ2/-DQ8. crude rate calculated as per 1000 live births 100,000 person-years age.A total 974 included. median...
Abstract Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of tuberculosis (TB) disease, primarily due to reactivation latent TB infection (LTBI). We assessed the performance parallel LTBI screening tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube assays (QFT-GIT) before anti-TNF-α treatment in children immune-mediated inflammatory disorders a low TB-burden setting. conducted multicenter cohort study involving 17 pediatric tertiary centers Spain....