A5069100941- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Inflammasome and immune disorders
- Musculoskeletal pain and rehabilitation
- Occupational Health and Performance
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Palsy and Movement Disorders
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Kawasaki Disease and Coronary Complications
- Infant Development and Preterm Care
- Stroke Rehabilitation and Recovery
- Medical research and treatments
- Pregnancy-related medical research
- Family and Disability Support Research
- Connective tissue disorders research
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Retinal and Optic Conditions
- Balance, Gait, and Falls Prevention
- Injury Epidemiology and Prevention
- Lung Cancer Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
Universidad Católica San Antonio de Murcia
2017-2025
Universidad de Murcia
2011-2025
Hospital Universitari i Politècnic La Fe
2014-2024
Instituto de Investigación Sanitaria La Fe
2013-2023
Asociación Española de Urología
2023
Spanish Clinical Research Network
2017-2022
Consejería de Educación de la Junta de Castilla y León
2011-2020
Istituto Giannina Gaslini
2013-2020
Hospital Comarcal de Inca
2020
Cultura
2020
Systemic juvenile idiopathic arthritis (JIA) is the most severe subtype of JIA; treatment options are limited. Interleukin-6 plays a pathogenic role in systemic JIA.We randomly assigned 112 children, 2 to 17 years age, with active JIA (duration ≥6 months and inadequate responses nonsteroidal antiinflammatory drugs glucocorticoids) anti-interleukin-6 receptor antibody tocilizumab (at dose 8 mg per kilogram body weight if was ≥30 kg or 12 <30 kg) placebo given intravenously every weeks during...
Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed efficacy and safety canakinumab, a selective, fully human, anti–interleukin-1β monoclonal antibody, two trials.
Objective To evaluate the interleukin-6 receptor inhibitor tocilizumab for treatment of patients with polyarticular-course juvenile idiopathic arthritis (pcJIA). Methods This three-part, randomised, placebo-controlled, double-blind withdrawal study ( NCT00988221 ) included who had active pcJIA ≥6 months and inadequate responses to methotrexate. During part 1, received open-label every 4 weeks (8 or 10 mg/kg body weight (BW) <30 kg; 8 BW ≥30 kg). At week 16, ≥JIA-American College...
To assess the efficacy of tocilizumab (TCZ) for treatment juvenile idiopathic arthritis (JIA)-associated uveitis.We conducted a multicenter study patients with JIA-associated uveitis that was refractory to conventional immunosuppressive drugs and anti-tumor necrosis factor (anti-TNF) agents.We assessed 25 (21 female; 47 affected eyes) mean ± SD age 18.5 8.3 years. Uveitis bilateral in 22 patients. Cystoid macular edema present 9 Ocular sequelae found at initiation TCZ included cataracts (n =...
: Familial cold autoinflammatory syndrome, Muckle-Wells syndrome (MWS), and chronic, infantile, neurological, cutaneous articular (CINCA) are dominantly inherited diseases associated to gain-of-function NLRP3 mutations included in the cryopyrin-associated periodic syndromes (CAPS). A variable degree of somatic mosaicism has been detected ≈35% patients with CINCA. However, no data currently available regarding relevance this mechanism other CAPS phenotypes.To evaluate as disease-causing...
Objective. To propose a reduced joint power Doppler US (PDUS) assessment and provide preliminary evidence of its validity, feasibility, reliability sensitivity to change compared with comprehensive (i.e. 44 joints) PDUS in evaluating synovitis JIA. Methods. This multicentre study included 42 children active JIA ≥4 clinically involved joints requiring modified therapy. At each visit, clinical assessments were performed blinded. Each was scored for greyscale (GS) signal according 4-point...
Objective To evaluate the efficacy and safety of canakinumab treatment in active hyperimmunoglobulinemia D with periodic fever syndrome (HIDS). Methods This was a 3‐part open‐label study an initial 6‐month period which patients HIDS (n = 9) received subcutaneously at dose 300 mg (or 4 mg/kg for those weighing ≤40 kg) every 6 weeks (period 1 [P1]), followed by withdrawal 2 [P2]), then 24‐month extension same 3 [P3]). The primary end point reduction frequency attacks during periods as compared...
After hospitalization caused by COVID-19, a high prevalence of physical deterioration has been observed, hence the importance having tests to evaluate functional status patients and be able perform partition subsequent referral physiotherapy service. This cross-sectional observational study describes according short performance battery (SPPB) admitted hospital setting for COVID-19 identify variables potentially related this outcome. Thirty-six in first wave living community. Patients were...
Severe variants of fibrodysplasia ossificans progressiva (FOP) affect <2% all FOP patients worldwide, but provide an unprecedented opportunity to probe the phenotype–genotype relationships that propel pathology this disabling disease. We evaluated two unrelated children who had severe reduction deficits hands and feet with absence nails, progressive heterotopic ossification, hypoplasia brain stem, motor cognitive developmental delays, facial dysmorphology, small malformed teeth, abnormal...
Abstract Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of tuberculosis (TB) disease, primarily due to reactivation latent TB infection (LTBI). We assessed the performance parallel LTBI screening tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube assays (QFT-GIT) before anti-TNF-α treatment in children immune-mediated inflammatory disorders a low TB-burden setting. conducted multicenter cohort study involving 17 pediatric tertiary centers Spain....
The high prevalence of malnutrition in the growing population older adults makes screening critical, especially hospitalized elderly patients. aim our study was to evaluate use MNA® Mini Nutritional Assessment for rapid evaluation nutritional risk. A prospective cohort made 106 patients 65 years old or admitted an internal medicine ward a tertiary-care teaching hospital short form, phase, MNA-SF. In first 48 hours admission, full MNA questionnaire administered and laboratory tests...
Abstract Background Improving walking ability is a key objective in the treatment of children and adolescents with cerebral palsy, since it directly affects their activity participation. In recent years, robotic technology has been implemented gait treatment, which allows training longer duration repetition movement. To know effectiveness robotic-assisted trainer Walkbot combined physiotherapy compared to isolated we carried out clinical trial. Methods 23 participants, were divided into two...
Scurvy is a rare disease in developed countries. Risk groups include children with restricted diets, mainly patients who are autistic or have cerebral palsy. Furthermore, consumption of plant-based beverages has increased recent years, especially When the exclusive diet first year life and not consumed as supplement to formula breastfeeding, it can result severe nutritional problems. We report case scurvy after intake almond flour from 2.5 11.0 months life. The patient was referred for...
<h3>Background</h3> The IL-6 receptor inhibitor TCZ was investigated for the treatment of sJIA patients (pts) in ongoing 3-part, 5-y, phase 3 TENDER study. <h3>Objectives</h3> Long-term efficacy and safety are presented. <h3>Methods</h3> 112 pts 2-17 y with active ≥6 mo were randomised 2:1 to (8 mg/kg if body weight ≥30 kg; 12 <30 kg, n=75) or placebo (n=37) every 2 wks part 1; all received open-label (to 104 wks). Oral corticosteroid (CS) tapering permitted according pre-defined...