A5004842261- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Neurological Complications and Syndromes
- Vascular Malformations Diagnosis and Treatment
- Neurological and metabolic disorders
- Pharmacological Effects and Toxicity Studies
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Eosinophilic Disorders and Syndromes
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Autoimmune Neurological Disorders and Treatments
- Health, Environment, Cognitive Aging
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Pain Management and Treatment
- Blood Pressure and Hypertension Studies
- Eosinophilic Esophagitis
- Hospital Admissions and Outcomes
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2020-2025
Hospital Clínico San Carlos
2014-2024
Universidad Complutense de Madrid
2021-2023
The effect of cultural differences in neurodegenerative diseases is not well understood. We aimed to investigate the cognitive profiles English- and Spanish-speaking individuals with primary progressive aphasia (PPA). A comparative cross-sectional study was conducted 461 participants: 215 participants from Australia 246 Spain. Australian cohort included 131 PPA patients: 37 nonfluent (nfvPPA), 49 semantic (svPPA), 45 logopenic (lvPPA) 84 healthy controls (HC); Spanish had 162 PPA: 64 nfvPPA,...
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More than 10 million Europeans show signs of mild cognitive impairment (MCI), a transitional stage between normal brain aging and dementia memory disorder. The path MCI takes can be divergent; while some maintain stability or even revert to norms, alarmingly, up half the cases progress within 5 years. Current diagnostic practice lacks necessary screening tools identify those at risk progression. European patient experience often involves long journey from initial eventual diagnosis dementia....
Abstract Background Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain retina part the central nervous system share pathophysiological mechanisms in AD. Methods We performed cross-sectional study with 30 participants without AD (FH−) noncarriers ApoE (ApoE ɛ4−) as control group 34 (FH+) carriers at least one ɛ4+). analyzed correlations between macular volumes retinal layers thickness peripapillary nerve fiber layer...
Alzheimer's disease (AD) prevalence is rapidly growing as worldwide populations grow older. Available treatments have failed to slow down progression, thus increasing research focus towards early or preclinical stages of the disease. Subjective cognitive decline (SCD) known increase risk developing AD and several other negative outcomes. However, it still very scarcely characterized there no neurophysiological study devoted its individual classification which could improve targeted sample...
ABSTRACT Limbic encephalitis is a condition characterised by an acute or sub‐acute onset of memory disorder, associated with seizures and psychiatric manifestations. Investigations such as brain MRI usually reveal high intensity signal in the medial temporal lobe cerebrospinal fluid analysis shows mild pleocytosis oligoclonal bands. It may occur association cancer, infection, isolated clinical condition, often accompanying autoimmune disorders. Immune‐mediated limbic now subclassified...
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a life-threatening disorder that often occurs as paraneoplastic and usually begins with neuropsychological or psychiatric symptoms. We report case of NMDA due to an ovarian teratoma, which began severe progressive amnesia behavioral changes, reversed after surgical treatment plasmapheresis. Using battery cognitive tests, its profile before showed complete alteration the short long term memory both verbal visual fixation, clear...
Abstract Background Electrophysiological studies show that reductions in power within the alpha band are associated with Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor has proved to reduce AD risk and pathological brain burden. Previous research confirmed exercise increases range. However, little known regarding whether other non-modifiable factors for AD, such as increased age or APOE ε4 carriage, alter association between PA band. Methods The relationship...
Introduction The evaluation of red flags is crucial for the accurate diagnosis headache disorders, especially thunderclap headache. We analysed if secondary disorders were adequately ruled out in patients that presented to emergency room with Methods In this retrospective cohort study, we screened all visited headache, including those described measured frequency which causes not out. order exams, final diagnosis, and time elapsed between arrival, initial request imaging, completion imaging....
The prognostic capacity of the diffusion tensor imaging measures fractional anisotropy (FA) and mean diffusivity (MD) to detect mild cognitive impairment (MCI) progression Alzheimer's disease (AD) was assessed in 135 MCI patients 72 healthy subjects over a median follow-up 40 months. Forty-nine (36.3%) developed AD. factors MD left hippocampus, FA cingulate, hippocampus emerged as predictors progression. Age (hazard ratio [HR] 1.21), delayed text recall (HR 0.89), uncinate 1.90), 2.21),...
Recent studies demonstrated that brain hypersynchrony is an early sign of dysfunction in Alzheimer's disease (AD) can represent a proxy for clinical progression. Conversely, non-pharmacological interventions, such as cognitive training (COGTR), are associated with gains may be underpinned by neuroprotective effect on synchrony.To study the potential COGTR to modulate synchrony and eventually revert phenomenon characterizes preclinical AD.The was examined sample healthy controls (HC, n = 41,...
To describe the utility of Barratt scale as a measure impulsivity and divergence perceptions between patients relatives, in cases diagnosed with bv-FTD. The was applied to 9 (5 men / 4 women, mean age 67.16 years old average schooling, 8.5), bv-FTD (Lund-Manchester criteria) close family, filling separately, double-blind . Assessment made more extensive neurobehavioral neuropsychological tests (MMSE, Blessed personality subscale digit span, TMT A, Stroop). Impulsiveness Scale chosen for...
Cerebrovascular damage from small vessel disease (SVD) occurs in healthy and pathological aging. SVD markers, such as white matter hyperintensities (WMH), are commonly found individuals over 60 increase prevalence with age. WMHs detectable on standard MRI by adhering to the STRIVE criteria. Currently, visual assessment scales used clinical research scenarios but is time-consuming has rater variability, limiting its practicality. Addressing this issue, our study aimed determine most precise...