A5083801686- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Dementia and Cognitive Impairment Research
- Retinal Development and Disorders
- Alzheimer's disease research and treatments
- Ophthalmology and Visual Impairment Studies
- Biomedical Text Mining and Ontologies
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Skin Protection and Aging
- Infant Health and Development
- Endoplasmic Reticulum Stress and Disease
- Technology and Human Factors in Education and Health
- Topic Modeling
- Cerebrospinal fluid and hydrocephalus
- Saffron Plant Research Studies
- Neurological diseases and metabolism
- Neonatal and fetal brain pathology
- Genetic Neurodegenerative Diseases
- Healthcare and Venom Research
- Coenzyme Q10 studies and effects
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
Universidad Complutense de Madrid
2020-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2025
Instituto de Salud Carlos III
2021-2022
Instituto Ramón y Cajal de Investigación Sanitaria
2021-2022
Hospital Clínico San Carlos
2022
Glaucoma is a neurodegenerative disease of the retina characterized by irreversible loss retinal ganglion cells (RGCs) leading to visual loss. Degeneration RGCs and their axons, as well damage remodeling lamina cribrosa are main events in pathogenesis glaucoma. Different molecular pathways involved RGC death, which triggered exacerbated consequence number risk factors such elevated intraocular pressure (IOP), age, ocular biomechanics, or low perfusion pressure. Increased IOP one most...
The murine models of Alzheimer’s disease (AD) have advanced our understanding the pathophysiology. In vivo studies retina using optical coherence tomography (OCT) complemented histological methods; however, lack standardisation in OCT methodologies for AD has led to significant variations results different studies. A literature search PubMed and Scopus been performed review methods used these analyse methodological characteristics each study. addition, some recommendations are offered...
Abstract Background Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain retina part the central nervous system share pathophysiological mechanisms in AD. Methods We performed cross-sectional study with 30 participants without AD (FH−) noncarriers ApoE (ApoE ɛ4−) as control group 34 (FH+) carriers at least one ɛ4+). analyzed correlations between macular volumes retinal layers thickness peripapillary nerve fiber layer...
Aims/Purpose: Transgenic mouse models of Alzheimer's disease (AD) have shown a correlation between retinal abnormalities and brain pathology. The APP NL‐F/NL‐F murine humanized AD model accurately replicates many pathological features seen in patients. This study aims to analyze, using manual segmentation by optical coherence tomography (OCT), the changes occurring several layers at 6, 9, 12, 15, 17, 20 months age, comparison C57BL/6J mice (WT). Methods: A diachronic was conducted OCT for...
Aims/Purpose: Transgenic mouse models of Alzheimer's disease (AD) have shown a correlation between retinal abnormalities and brain pathology. The APP NL‐F/NL‐F murine humanized AD model accurately replicates many pathological features seen in patients. This study aims to analyze, using manual segmentation by optical coherence tomography (OCT), the changes occurring several layers at 6, 9, 12, 15, 17, 20 months age, comparison C57BL/6J mice (WT). Methods: A diachronic was conducted OCT for...
Aims/Purpose: Treatments for glaucoma damage have focused on lowering intraocular pressure (IOP). However, despite controlled IOP, the neurodegenerative process continues. Therefore, it is necessary to study new molecules with neuroprotective properties treatment. The aim of this was investigate survival retinal ganglion cells (RGCs) in an experimental model ocular hypertension (OHT) following administration a combination citicoline and coenzyme Q10 (COQUN Combo). Methods: Four groups Swiss...
Aims/Purpose: In Alzheimer's disease (AD), there are histopathological aspects that cannot be studied in patients, demanding the use of murine models disease. The APP NL‐F/NL‐F model reproduces pathophysiology quite faithfully. aim present study was to analyze retinal vascular structures and thickness an AD at different ages compares these findings age‐matched wild type (WT) controls. Methods: A diachronic conducted using spectral‐domain OCT angiography (SD‐OCTA) AngioTool software assess...
Aims/Purpose: To investigate the anti‐inflammatory effects of citicoline and coenzyme Q10 (COQUN Combo) in an experimental model ocular hypertension (OHT). Methods: Swiss albino mice were used: vehicle control (Vehicle n = 6), COQUN Combo 5), laser (LG+Veh, (LG+COQUN Combo, 6). was administered daily with gelatin 15 days prior to induction 3 post‐induction LG+COQUN groups. The Vehicle LG+Veh groups received neutral gelatin. OHT induced left eye by photocoagulation limbal episcleral veins,...
Aims/Purpose: In the last decades, retinal alterations have been shown by OCT in Alzheimer's disease (AD), initially affecting macular region early AD, and subsequently progressing to peripapillary retina, pointing out this tissue be considered for diagnosis follow‐up AD. This study aimed investigate changes patients with mild cognitive impairment (MCI), an intermediate stage between normal aging know if preclinical there are retina. Methods: Sixteen healthy subjects 16 MCI were included....
Aims/Purpose: In Alzheimer's disease (AD), there are histopathological aspects that cannot be studied in patients, demanding the use of murine models disease. The APP NL‐F/NL‐F model reproduces pathophysiology quite faithfully. aim present study was to analyze retinal vascular structures and thickness an AD at different ages compares these findings age‐matched wild type (WT) controls. Methods: A diachronic conducted using spectral‐domain OCT angiography (SD‐OCTA) AngioTool software assess...
Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) crucial for brain water homeostasis, with Aqp4 knockout mice showing sporadic increased content. Kinase D interacting substrate of 220 kDa (Kidins220), transmembrane protein involved neuronal survival, synaptic activity neurogenesis, controls AQP4 levels...
In Alzheimer's disease (AD), transgenic mouse models have established links between abnormalities in the retina and those brain.
In this case control study, we examined the retinal thickness of different layers in macular region and peripapillary nerve fiber layer (RNFL) with optical coherence tomography (OCT) healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five a family history Alzheimer (AD) (FH+) ApoE ɛ4 carriers 29 age-matched without AD (FH−) non-carriers were included. Compared FH− non-carriers, FH+ carriers, there statistically...
In 103 subjects with a high genetic risk of developing Alzheimer's disease (AD), family history (FH) AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), AngioTool Erlangen-Angio-Tool (EA-Tool) as imaging analysis software. Retinal vascularization was measuring hypercholesterolemia (HCL) blood pressure (HBP). Angio-Tool showed statistically significant higher percentage area occupied vessels...
Introduction Alzheimer’s disease (AD) is the most common form of dementia affecting central nervous system, and alteration several visual structures has been reported. Structural retinal changes are usually accompanied by in function this disease. The aim study was to analyse differences at different stages pathology (family history group (FH+), mild cognitive impairment (MCI), AD moderate AD) comparison with a control subjects no decline family AD. Methods We included 53 controls, 13 FH+,...
Alzheimer’s disease (AD) may manifest retinal changes preceding brain pathology. A transversal case-control study utilized spectral-domain OCT angiography (SD-OCTA) and Angio-Tool software 0.6a to assess vascular structures for inner outer retina thickness in the APPNL-F/NL-F AD model at 6, 9, 12, 15, 17, 20 months old. Comparisons age-matched wild type (WT) were performed. The analysis focused on three plexuses using AngiooTool thickness, which was represented with Early Treatment Diabetic...
Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, process often continues. Therefore, substances neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated neuroprotective effects on RGCs visual pathway neurons compound consisting citicoline coenzyme Q10 (CoQ10) in mouse model unilateral,...
Having a family history (FH+) of Alzheimer's disease (AD) and being carrier at least one ɛ4 allele the ApoE gene are two main risk factors for development AD. AD age-related macular degeneration (AMD) share factors, such as age, characteristics including presence deposits (Aβ plaques in drusen AMD); however, role apolipoprotein E isoforms both pathologies is controversial. We analyzed characterized retinal by optical coherence tomography (OCT) subjects, classifying them their FH (FH- or FH+)...
A family history (FH+) of Alzheimer’s disease (AD) and ɛ4 allele the ApoE gene are main genetic risk factors for developing AD, whereas plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported both pathologies. We analyzed choroidal thickness using optical coherence tomography (OCT) foveal avascular zone (FAZ) OCT-angiography compared results with expression, AD FH+, presence or absence hard drusen (HD) 184 cognitively healthy subjects....
This study aimed to analyze the evolution of visual changes in cognitively healthy individuals at risk for Alzheimer’s disease (AD). Participants with a first-degree family history AD (FH+) and carrying Ε4+ allele ApoE gene (ApoE ε4+) underwent retinal thickness analysis using optical coherence tomography (OCT) function assessments, including acuity (VA), contrast sensitivity (CS), color perception, perception digital tests, field analysis. Structural divided participants into FH+ ε4+ FH−...