A5043628704- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Saffron Plant Research Studies
- Neurological Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Neonatal and fetal brain pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Epilepsy research and treatment
- Flavonoids in Medical Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical effects in animals
- Advanced Glycation End Products research
- Protein Tyrosine Phosphatases
Universidad Complutense de Madrid
2018-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2025
Hospital Clínico San Carlos
2021-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2019-2022
Instituto de Salud Carlos III
2021-2022
Centro de Investigacion Principe Felipe
2021
Comunidad de Madrid
2021
Hospital Universitario Infanta Leonor
2021
Glaucoma is a neurodegenerative disease of the retina characterized by irreversible loss retinal ganglion cells (RGCs) leading to visual loss. Degeneration RGCs and their axons, as well damage remodeling lamina cribrosa are main events in pathogenesis glaucoma. Different molecular pathways involved RGC death, which triggered exacerbated consequence number risk factors such elevated intraocular pressure (IOP), age, ocular biomechanics, or low perfusion pressure. Increased IOP one most...
Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in intraocular pressure principal risk factor for such loss, but controlling this does not always prevent glaucomatous damage. Activation immune resident retina (microglia) may contribute to RGC death. Thus, substance with anti-inflammatory activity protect against degeneration. This study investigated neuroprotective and effects hydrophilic saffron extract standardized 3% crocin...
Abstract Microglial activation is associated with glaucoma. In the model of unilateral laser-induced ocular hypertension (OHT), time point at which inflammatory process peaks remains unknown. Different points (1, 3, 5, 8, and 15 d) were compared to analyze signs microglial both in OHT contralateral eyes. eyes, was detected all retinal layers analyzed, including: i) increase cell number outer segment photoreceptor layer plexiform (only eyes) from 3 d onward; ii) soma size 1 iii) retraction...
The murine models of Alzheimer’s disease (AD) have advanced our understanding the pathophysiology. In vivo studies retina using optical coherence tomography (OCT) complemented histological methods; however, lack standardisation in OCT methodologies for AD has led to significant variations results different studies. A literature search PubMed and Scopus been performed review methods used these analyse methodological characteristics each study. addition, some recommendations are offered...
In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (Aβ) aggregates replacing the contractile smooth musculature of arteriole walls. These happen in brain network, but also eye, and are related to decreased density low blood flow. patients with disease, thinning choroid retina has been shown. The aim this prospective study was assess retinal choroidal systems, analyzing thickness optical coherence tomography (OCT), foveal avascular zone (FAZ) OCT-angiography (OCTA),...
Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay immunohistochemical techniques a glaucoma mouse model at different time points after ocular hypertension (OHT), we analyzed (i) expression pro-inflammatory cytokines, anti-inflammatory BDNF, VEGF, fractalkine; (ii) number Brn3a+ RGCs. In OHT eyes, there was an upregulation IFN-γ days 3, 5, 15; IL-4 1, 7 IL-10 3 5...
Aims/Purpose: Transgenic mouse models of Alzheimer's disease (AD) have shown a correlation between retinal abnormalities and brain pathology. The APP NL‐F/NL‐F murine humanized AD model accurately replicates many pathological features seen in patients. This study aims to analyze, using manual segmentation by optical coherence tomography (OCT), the changes occurring several layers at 6, 9, 12, 15, 17, 20 months age, comparison C57BL/6J mice (WT). Methods: A diachronic was conducted OCT for...
Aims/Purpose: Transgenic mouse models of Alzheimer's disease (AD) have shown a correlation between retinal abnormalities and brain pathology. The APP NL‐F/NL‐F murine humanized AD model accurately replicates many pathological features seen in patients. This study aims to analyze, using manual segmentation by optical coherence tomography (OCT), the changes occurring several layers at 6, 9, 12, 15, 17, 20 months age, comparison C57BL/6J mice (WT). Methods: A diachronic was conducted OCT for...
Aims/Purpose: Treatments for glaucoma damage have focused on lowering intraocular pressure (IOP). However, despite controlled IOP, the neurodegenerative process continues. Therefore, it is necessary to study new molecules with neuroprotective properties treatment. The aim of this was investigate survival retinal ganglion cells (RGCs) in an experimental model ocular hypertension (OHT) following administration a combination citicoline and coenzyme Q10 (COQUN Combo). Methods: Four groups Swiss...
Aims/Purpose: In Alzheimer's disease (AD), there are histopathological aspects that cannot be studied in patients, demanding the use of murine models disease. The APP NL‐F/NL‐F model reproduces pathophysiology quite faithfully. aim present study was to analyze retinal vascular structures and thickness an AD at different ages compares these findings age‐matched wild type (WT) controls. Methods: A diachronic conducted using spectral‐domain OCT angiography (SD‐OCTA) AngioTool software assess...
Aims/Purpose: To investigate the anti‐inflammatory effects of citicoline and coenzyme Q10 (COQUN Combo) in an experimental model ocular hypertension (OHT). Methods: Swiss albino mice were used: vehicle control (Vehicle n = 6), COQUN Combo 5), laser (LG+Veh, (LG+COQUN Combo, 6). was administered daily with gelatin 15 days prior to induction 3 post‐induction LG+COQUN groups. The Vehicle LG+Veh groups received neutral gelatin. OHT induced left eye by photocoagulation limbal episcleral veins,...
Aims/Purpose: In the last decades, retinal alterations have been shown by OCT in Alzheimer's disease (AD), initially affecting macular region early AD, and subsequently progressing to peripapillary retina, pointing out this tissue be considered for diagnosis follow‐up AD. This study aimed investigate changes patients with mild cognitive impairment (MCI), an intermediate stage between normal aging know if preclinical there are retina. Methods: Sixteen healthy subjects 16 MCI were included....
Aims/Purpose: In Alzheimer's disease (AD), there are histopathological aspects that cannot be studied in patients, demanding the use of murine models disease. The APP NL‐F/NL‐F model reproduces pathophysiology quite faithfully. aim present study was to analyze retinal vascular structures and thickness an AD at different ages compares these findings age‐matched wild type (WT) controls. Methods: A diachronic conducted using spectral‐domain OCT angiography (SD‐OCTA) AngioTool software assess...
Loss-of-function mutations in ADAMTSL4, a gene encoding an extracellular matrix-associated protein with incompletely understood biological roles, are linked to autosomal recessive disorders predominantly characterized by lens dislocation. Pupil ectopia, increased intraocular pressure, retinal detachment, cataracts, and skeletal abnormalities also observed some patients. To investigate ADAMTSL4 biology related diseases we established zebrafish knockout line using CRISPR/Cas9 genome editing....
Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) crucial for brain water homeostasis, with Aqp4 knockout mice showing sporadic increased content. Kinase D interacting substrate of 220 kDa (Kidins220), transmembrane protein involved neuronal survival, synaptic activity neurogenesis, controls AQP4 levels...
Alzheimer's disease (AD) is the most common type of dementia in world. The main biomarkers associated with AD are protein amyloid-β (Aβ) plaques and tau neurofibrillary tangles, which responsible for brain neuroinflammation mediated by microglial cells. Increasing evidence has shown that retina can also be affected AD, presenting some molecular cellular changes brain, such as microglia activation. However, there only a few studies assessing retinal animal models AD. These use sections, have...
Abstract Background Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain retina part the central nervous system share pathophysiological mechanisms in AD. Methods We performed cross-sectional study with 30 participants without AD (FH−) noncarriers ApoE (ApoE ɛ4−) as control group 34 (FH+) carriers at least one ɛ4+). analyzed correlations between macular volumes retinal layers thickness peripapillary nerve fiber layer...
In Alzheimer's disease (AD), transgenic mouse models have established links between abnormalities in the retina and those brain.