A5091493801- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological diseases and metabolism
- Migraine and Headache Studies
- Frailty in Older Adults
- Mental Health and Psychiatry
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Hearing Loss and Rehabilitation
- Restless Legs Syndrome Research
- Ophthalmology and Eye Disorders
- Phytoestrogen effects and research
- Spatial Neglect and Hemispheric Dysfunction
Marqués de Valdecilla University Hospital
2023-2025
Instituto de Investigación Marqués de Valdecilla
2023-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2024-2025
Instituto de Salud Carlos III
2024-2025
Clinica Universidad de Navarra
2018-2024
Hospital Clínico San Carlos
2013-2021
Universidad de Navarra
2020-2021
Cambridge University Press
2021
New York University Press
2021
Navarre Institute of Health Research
2020-2021
ABSTRACT Background: Addenbrooke's Cognitive Examination III (ACE-III) is a screening test that was recently validated for diagnosing dementia. Since it assesses attention, language, memory, fluency, and visuospatial function separately, may also be useful general neuropsychological assessments. The aim of this study to analyze the tool's ability detect early stages Alzheimer's disease examine correlation between ACE-III scores on standardized tests. Methods: Our included 200 participants...
The arrival of new disease-modifying treatments for Alzheimer's disease (AD) requires the identification subjects at risk in a simple, inexpensive, and non-invasive way. With tools allowing an adequate screening, it would be possible to optimize use these treatments. Plasma markers AD are very promising, but is necessary prove that alterations their levels related gold standard such as cerebrospinal fluid or PET imaging. this research, we want evaluate performance plasma Aβ40, Aβ42, p-tau181...
Plasma biomarkers for Alzheimer’s disease (AD) are a promising tool that may help in early diagnosis. However, their levels be influenced by physiological parameters and comorbidities should considered before they can used at the population level. For this purpose, we assessed influences of different on AD plasma markers 208 cognitively unimpaired subjects. We analyzed both cerebrospinal fluid Aβ40, Aβ42, p-tau181 using fully automated Lumipulse platform. The relationships between variables...
Plasma biomarkers for Alzheimer's disease (AD) are a promising tool accessible and accurate biological diagnostics. However, data in clinical practice needed to better understand their diagnostic prognostic ability memory unit patients. We analyzed plasma phosphorylated tau at threonine 217 (p-tau217) neuroflament light chain (NfL) levels AD cerebrospinal fluid (CSF) group of 493 subjects using the Lumipulse G600II platform. The sample includes 340 patients from our (142 dementia, 186 mild...
Episodic memory disturbance is still considered as an exclusion criterion for behavioral variant frontotemporal dementia (bvFTD), but growing evidence suggests that can be impaired.Our main purposes were to assess episodic in a group of bvFTD patients comparatively with Alzheimer's disease (AD) patients, and analyze the relationship between brain metabolism measured using positron emission tomography imaging 18F-fluorodeoxyglucose (FDG-PET).Twenty-six bvFTD, 29 AD, 24 healthy controls...
Apathy is one of the most common and disabling syndromes dementia. Clinical apathy expression neuroanatomical basis seem to differ between behavioral variant frontotemporal dementia (bvFTD) Alzheimer's disease (AD), although evidence scarce poorly understood. Our main purposes were compare clinical profile from patients with bvFTD AD analyze relationship brain metabolism measured using positron emission tomography imaging 18 F fluorodeoxyglucose (FDG-PET).Forty-two bvFTD, 42 AD, 30 healthy...
The Hayling Sentence Completion Test evaluates the ability to inhibit an automatic response. It has also been suggested for assessment of orbitofrontal cortex function. aim study was develop a Spanish version test and obtain normative data.Responses 60 sentences from 50 healthy controls were used task. Additionally, 185 aged between 18 99 years examined with in order data. overlapping interval strategy maximize sample size. Age- education-adjusted scores obtained using linear regression...
Background: The Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L) is a novel cognitive test that measures recovery from proactive semantic interference, which may be an early marker of Alzheimer’s disease (AD). Objective: To generate normative data Spaniard population to validate the LASSI-L diagnosis amnestic mild impairment (aMCI) AD. Methods: We performed cross-sectional study in 97 healthy participants, 34 with aMCI, 33 AD were studied comprehensive...
Background: Plasma biomarkers of Alzheimer’s disease (AD) constitute a non-invasive tool for diagnosing and classifying subjects. They change even in preclinical stages, but it is necessary to understand their properties so they can be helpful clinical context. Objective: With this work we want study the evolution p-tau231 plasma levels stages AD its relationship with both cognitive imaging parameters. Methods: We evaluated phosphorylated (p)-tau231 146 cognitively unimpaired subjects...
Epicrania fugax (EF) is a primary headache of recent description. We aimed to report 19 new cases EF, and thus contribute the characterization this emerging headache.EF characterized by painful paroxysms starting in particular area head, rapidly radiating forwards or backwards through territories different nerves. The pain felt quick motion along lineal zigzag trajectory. To date, 47 have been published, 34 with forward EF 13 backward EF.We performed descriptive study all attending our...
Background: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis Parkinson’s disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD (iPD) associated with G2019S variant LRRK2 (L2PD), as well evaluate function in asymptomatic carriers LRRK2. Methods: The study enrolled 129 subjects: 30 (16 iPD, 14 L2PD), 23 carriers, 13 non-carrier...
Objectives To assess and compare the prevalence of migraine in patients with restless legs syndrome ( RLS ) matched controls. Background Recent studies have suggested an association between . Our work is first case–control study on this subject performed population. Methods A was conducted 47 (27 women 20 men aged 18 65 years) age‐ sex‐matched Validated questionnaires were used to investigate presence migraine, anxiety, depression Z ung S elf‐ R ating nxiety D epression scales), sleep...
Subjective cognitive decline (SCD) may represent a preclinical stage of Alzheimer's disease (AD). Predicting progression SCD patients is great importance in AD-related research but remains challenge.To develop and implement an ensemble machine learning (ML) algorithm to identify subjects at risk conversion mild impairment (MCI) or AD.Ninety-nine were included. Thirty-two progressed MCI/AD, while 67 remained stable. To minimize the effect class imbalance, both classes balanced, sensitivity...
Abstract The global growing rates of cognitive decline and dementia, together with the absence curative therapies for these conditions, support interest in researching potential primary prevention interventions, particular focus on dietary habits. aim was to assess association between polyphenol intake 6-year change function ‘Seguimiento Universidad de Navarra’ (SUN) Project, a Spanish prospective cohort study. Changes (final – initial) were evaluated subsample 806 participants (mean age 66...
Background: With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive Alzheimer’s disease (AD) pathology in preclinical stages. Objective: To determine utility a newly developed Learning and Associative Memory face test: LAM test. This study examined relationship between AD cerebrospinal fluid (CSF) biomarkers performance on test, assessed its potential clinical applicability detect subtle changes cognitively healthy subjects at risk...
Available evidence on the association of physical activity (PA) or sedentary behavior with cognitive decline is inconclusive.To assess between an active lifestyle score and leisure-time (LTPA) changes in function Seguimiento Universidad de Navarra (SUN) prospective cohort.Cognitive was evaluated a subsample 806 participants SUN cohort study using validated Telephone Interview for Cognitive Status-modified (STICS-m) questionnaire at baseline after 6 years. LTPA previously 17-item...