A5026208704- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Health, Environment, Cognitive Aging
- Cognitive Functions and Memory
- Brain Tumor Detection and Classification
- Machine Learning in Healthcare
- Neurological Disease Mechanisms and Treatments
- Patient-Provider Communication in Healthcare
- Memory and Neural Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- S100 Proteins and Annexins
- Artificial Intelligence in Healthcare
- Frailty in Older Adults
- Diet and metabolism studies
- Palliative Care and End-of-Life Issues
- Ethics in medical practice
- Spinal Cord Injury Research
- Technology Use by Older Adults
- Traumatic Brain Injury Research
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Nerve injury and regeneration
University of Miami
2016-2025
Alzheimer’s Disease Neuroimaging Initiative
2020-2024
University of Florida
2018-2024
Jackson Health System
2023
Florida Atlantic University
2018-2023
Florida College
2023
University of Florida Health
2023
Mount Sinai Medical Center
2017-2018
Florida International University
2018
University of Buenos Aires
2018
The rationale for implantation of autologous human Schwann cells (SCs) in persons with subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are neuroprotective, support local axonal plasticity, and capable myelinating axons. A Phase I clinical trial was conducted to evaluate the safety SC transplantation into epicenter six subjects SCI. an open-label, unblinded, non-randomized, non-placebo controlled study a dose escalation design standard medical rehabilitation....
A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility and safety of autologous human Schwann cell (ahSC) transplantation accompanied by rehabilitation in participants with chronic spinal cord injury (SCI). Magnetic resonance imaging (MRI) used screen eligible estimate an individualized volume suspension be implanted. The incorporated standardized multi-modal before after delivery. Participants underwent sural nerve harvest, ahSCs were isolated propagated...
<h3>Objective</h3> Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI occur greater frequency persons amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who clinical symptoms of aMCI-AD negative scans (suspected non-AD pathology [SNAP]) or are diagnosed other brain disorders affecting cognition. <h3>Methods</h3>...
Predicting the progression of Alzheimer's Disease (AD) has been held back for decades due to lack sufficient longitudinal data required development novel machine learning algorithms. This study proposes a algorithm predicting disease using distributed multimodal, multitask method. More specifically, each individual task is defined as regression model, which predicts cognitive scores at single time point. Since prediction tasks multiple intervals are related other in chronological order,...
This study aims to evaluate the extent which sleep quality impacts amnestic mild cognitive impairment (aMCI)-related brain regions in a cognitively normal cohort of individuals. Seventy-four participants were rigorously evaluated using battery tests and detailed clinical assessment verify status. We then screened for Pittsburgh Sleep Quality Index (PSQI) depressive symptoms Geriatric Depression Scale (GDS). Five subjects excluded due depression. Overall 38 individuals with mean age 70.7 ± 7...
Introduction This study investigated the role of proactive semantic interference (frPSI) in predicting progression amnestic Mild Cognitive Impairment (aMCI) to dementia, taking into account various cognitive and biological factors. Methods The research involved 89 older adults with aMCI who underwent baseline assessments, including amyloid PET MRI scans, were followed longitudinally over a period ranging from 12 55 months (average 26.05 months). Results findings revealed that more than 30%...
Mild cognitive impairment (MCI) is a clinical diagnosis representing early symptom changes with preserved functional independence. There are multiple potential etiologies of MCI. While often presumed to be related Alzheimer's disease (AD), other neurodegenerative and non-neurodegenerative causes common. Wider availability relatively non-invasive plasma AD biomarkers, such as p-tau217, can provide invaluable insights into MCI clinico-pathology the associated implications for etiology,...
Huntington's disease (HD) is characterized by progressive cognitive decline, with early deficits often preceding motor symptoms. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) captures many types of in verbal memory including susceptibility to interference. current study aims delineate the progression these across different stages HD. 151 participants (89 HD, 62 healthy controls) were recruited three sites. HD classified into groups using a PIN score TMS: >10...
There is growing evidence that proactive semantic interference (PSI) and failure to recover from PSI may represent early features of Alzheimer's disease (AD).This study investigated the association between PSI, recovery reduced MRI volumes in AD signature regions among cognitively impaired unimpaired older adults.Performance on LASSI-L (a novel test PSI) regional brain volumetric measures were compared 38 normal (CN) elders 29 participants with amnestic mild cognitive impairment (MCI). The...
The potential impact of test anxiety on cognitive testing was examined in a sample 300 predominantly male veteran referrals who were administered comprehensive neuropsychological battery. Exclusionary criteria included failure effort (n= 14). Level significantly related to performance the WAIS-III Working Memory Index (r = -.343, p < .001) but not scores Processing Speed, Perceptual Organization, or Verbal Comprehension indexes. Test global index HRNES-R (Average Impairment Scale). education...
Objective:The authors evaluated the psychometric properties and clinical utility of Loewenstein-Acevedo Scale for Semantic Interference Learning (LASSI-L), in patients with amnestic Mild Cognitive Impairment (aMCI) early Alzheimer's disease (AD).Methods: Subjects were administered Target List A instructed to remember 15 common words belonging a specific semantic category, using multi-modal, active encoding procedures.After free recall cued trials target list, second learning trial was...
Background: New research criteria for diagnosing Alzheimer's disease (AD) in the mild cognitive impairment stage (MCI-AD) incorporate biomarkers to assign a level of certainty diagnosis. Structural MRI is widely available but greatly under-utilized assessing atrophy structures affected early AD, such as hippocampus (HP), because quantification HP volumes (HP-v) requires special expertise, and normative values have not been established. Methods: Elderly subjects (n =273) from Florida ADRC...
Background: The Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L) is a novel cognitive test that measures recovery from proactive semantic interference, which may be an early marker of Alzheimer’s disease (AD). Objective: To generate normative data Spaniard population to validate the LASSI-L diagnosis amnestic mild impairment (aMCI) AD. Methods: We performed cross-sectional study in 97 healthy participants, 34 with aMCI, 33 AD were studied comprehensive...
Background: Recent findings indicate that impairments in functional performance do occur among individuals diagnosed with mild cognitive impairment (MCI). Most assessment strategies for everyday competence are associated challenges reliability, typically paper and pencil format, or require in-person administration by a trained professional. Objective: This reports on novel technology-based battery of includes ecologically valid simulations daily activities important to independence. Methods:...
Background: The rise in incidence of Alzheimer’s disease (AD) has led to efforts advance early detection the during its preclinical stages. To achieve this, field needs develop more sensitive cognitive tests that relate biological markers pathology. Failure recover from proactive interference (frPSI) is one such marker associated with volumetric reductions hippocampus, precuneus, and other AD-prone regions, amyloid load brain. Objective: current study attempted replicate extend our previous...
The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, Loewenstein-Acevedo Scale Semantic Interference Learning (LASSI-L), has been developed in order to provide an early diagnosis.To compare diagnostic accuracy FCSRT LASSI-L AD its preclinical stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as reference.Fifty patients consulting subjective memory complaints...
Abstract Objectives: Maintaining two active languages may increase cognitive and brain reserve among bilingual individuals. We explored whether such a neuroprotective effect was manifested in the performance of memory tests for participants with amnestic mild impairment (aMCI). Methods: compared 42 bilinguals to 25 monolinguals on verbal nonverbal tests. used: (a) Loewenstein-Acevedo Scales Semantic Interference Learning (LASSI-L), sensitive test that taps into proactive, retroactive,...