Luis A. Sierra

ORCID: 0000-0002-1932-5556
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About
Contact & Profiles
Research Areas
  • Genetic Neurodegenerative Diseases
  • Neurological disorders and treatments
  • Mitochondrial Function and Pathology
  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Geological and Tectonic Studies in Latin America
  • Neurology and Historical Studies
  • Critical Theory and Philosophy
  • Diatoms and Algae Research
  • Neurobiology of Language and Bilingualism
  • Algal biology and biofuel production
  • Dementia and Cognitive Impairment Research

Beth Israel Deaconess Medical Center
2022-2025

Yahoo (United Kingdom)
2023

University of Miami
2019

Huntington's disease (HD) is characterized by progressive cognitive decline, with early deficits often preceding motor symptoms. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) captures many types of in verbal memory including susceptibility to interference. current study aims delineate the progression these across different stages HD. 151 participants (89 HD, 62 healthy controls) were recruited three sites. HD classified into groups using a PIN score TMS: >10...

10.3389/fneur.2025.1494816 article EN cc-by Frontiers in Neurology 2025-02-19

Semantic intrusion errors on memory tests may represent very early cognitive changes associated with elevated Alzheimer's disease pathology within the brain, including amyloid-β (Aβ). Subscales that measure proactive semantic interference (PSI) and intrusions related to PSI Loewenstein Acevedo Scales of Interference Learning (LASSI-L) have been high levels brain amyloid load, structural MRI in Hispanic non-Hispanic groups. It is presently unknown whether or other measures LASSI-L can...

10.3233/jad-191022 article EN Journal of Alzheimer s Disease 2019-12-24

Background: Diagnosis of manifest Huntington disease (HD) is based primarily on motor symptoms, but premanifest HD (preHD) often associated with subtle cognitive decline. The Loewenstein–Acevedo Scales for Semantic Interference and Learning (LASSI–L) a validated verbal learning test that can be used to detect early Objective: To determine the utility LASSI–L detecting decline in individuals preHD compare results those commonly neuropsychological tests HD. Method: We administered 13 healthy...

10.1097/wnn.0000000000000329 article EN Cognitive and Behavioral Neurology 2023-01-10

Background Cognitive decline in Huntington’s disease (HD) begins early the course, however reported prevalence and severity of cognitive impairment varies based on diagnostic approach. A Movement Disorders Society Task Force recently endorsed use standardized DSM-5-based criteria to diagnose neurocognitive disorder (NCD) disease. Objectives To determine across different stages HD by applying NCD (mild major) participant data from Enroll-HD database. Methods participants were triaged into...

10.3389/fneur.2023.1198145 article EN cc-by Frontiers in Neurology 2023-07-14

Cognitive decline is an important early sign in pre-motor manifest Huntington's disease (preHD) and characterized by deficits across multiple domains including executive function, psychomotor processing speed, memory retrieval. Prior work suggested that the Loewenstein-Acevedo Scale for Semantic Interference Learning (LASSI-L)-a verbal learning task simultaneously targets these - could capture cognitive changes preHD. The current study aimed to replicate, validate further analyze LASSI-L...

10.3389/fneur.2023.1191718 article EN cc-by Frontiers in Neurology 2023-07-18

Las diatomeas Actinocyclus normanii , Cyclotella gromerata y Neodelphyneis pelagica fueron trabajadas en el laboratorio de Alimento Vivo la Universidad Córdoba, con fin caracterizar las especies, obtener cepas realizar cultivos experimentales bajo condiciones controladas temperatura (24oC), salinidad (25-30 0/00) aireación. Cultivos a 5 ml 250 realizados dos medios cultivo como tratamiento (F/2 Guillar & Rither, CONWAY) para determinar su efecto sobre productividad. Mediante...

10.21897/rmvz.476 article ES cc-by-sa Revista Mvz Córdoba 2005-01-01

Background: Huntington’s disease (HD) is a neurodegenerative disorder marked by cognitive impairment, movement abnormalities, and behavioral disturbances. The Stroop Color Word Test (SCWT) widely used tool to detect decline in HD. Variations SCWT formats—horizontal (original) vertical (Golden)—may influence performance, given HD’s impact on oculomotor abilities. Objective: This study aimed compare the effectiveness of horizontal Golden formats detecting HD, determine how performance may have...

10.3233/jhd-231528 article EN Journal of Huntington s Disease 2024-05-14

<h3>Background</h3> Cognitive deficits typically precede motor manifestation in premanifest Huntington's disease (preHD) and can therefore serve as early biomarkers of progression. Subtle cognitive impairments HD have been detected on verbal learning paradigms, however optimal task design has not yet established. <h3>Aims</h3> We assessed impairment preHD by comparing performance two tasks: California Verbal Learning Test II (CVLT-II) the Loewenstein-Acevedo Scales Semantic Interference...

10.1136/jnnp-2022-ehdn.127 article EN 2022-09-01

El Departamento de Nariño, por sus características geográficas y geológicas, se encuentra en amenaza alta eventos sísmicos volcánicos, escasamente conocida docentes escolares el ámbito la prevención del riesgo.En mayo 2020, Ministerio Ciencia, Tecnología e Innovación Colombia estableció “Lineamientos para una Política Nacional Apropiación Social Conocimiento, los ciudadanos ciudadanos”, concordante con pertinencia Gestión Riesgo, acorde Ley General Educación, necesidad adquirir conciencia “…...

10.22267/rhec.222828.102 article ES Revista Historia de la Educación Colombiana 2022-12-07
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