A5065466517- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Hearing Loss and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology of Language and Bilingualism
- Hearing, Cochlea, Tinnitus, Genetics
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Spatial Neglect and Hemispheric Dysfunction
- Older Adults Driving Studies
- Glioma Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Polyomavirus and related diseases
- Counseling, Therapy, and Family Dynamics
- Classical Philosophy and Thought
- Amyloidosis: Diagnosis, Treatment, Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Health disparities and outcomes
- Electroconvulsive Therapy Studies
- Identity, Memory, and Therapy
- Elder Abuse and Neglect
- Spatial Cognition and Navigation
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
Universidad de Extremadura
2022
Hospital Clínico San Carlos
2016-2021
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2016-2021
Universidad Complutense de Madrid
2016-2020
ABSTRACT Background: Addenbrooke's Cognitive Examination III (ACE-III) is a screening test that was recently validated for diagnosing dementia. Since it assesses attention, language, memory, fluency, and visuospatial function separately, may also be useful general neuropsychological assessments. The aim of this study to analyze the tool's ability detect early stages Alzheimer's disease examine correlation between ACE-III scores on standardized tests. Methods: Our included 200 participants...
<b><i>Background:</i></b> Addenbrooke's Cognitive Examination III (ACE-III) is a cognitive test that has been validated for the diagnosis of disorders. The aim this study was to provide normative data ACE-III age, education and gender. <b><i>Methods:</i></b> Spanish version administered group 273 healthy subjects in multicenter Spain. Correlation determination coefficients gender were estimated. overlapping interval strategy linear regression...
Cognitive impairment is frequent and disabling in multiple sclerosis (MS). Changes information processing speed constitute the most important cognitive deficit MS. However, given clinical topographical variability of disease, may vary greatly appear other forms addition to slower speed. Our aim was determine frequency impairment, principal domains, components involved MS identify factors associated with presence these patients a large series patients.Cross-sectional study 311 [236...
Objective: Cognitive impairment is an important feature in multiple sclerosis (MS) and has been associated to several Magnetic Resonance Imaging (MRI) markers, but especially brain atrophy. However, the relationship between specific neuropsychological tests examining cognitive functions volumes little explored. Furthermore, because MS frequently damage subcortical regions, it may be interesting model examine role of areas functioning. Our aim was identify correlations regions performance...
Background: Verbal fluency (VF) has been associated with several cognitive functions, but the processes underlying verbal deficits in Multiple Sclerosis (MS) are controversial. Further knowledge about VF could be useful clinical practice, because these tasks brief, applicable, and reliable MS patients. In this study, we aimed to evaluate related develop machine-learning algorithms predict those patients using only VF-derived scores. Methods: Two hundred participants were enrolled examined a...
ABSTRACTBackground:We aim to provide a conversion between Addenbrooke's Cognitive Examination III (ACE-III) and Mini-Mental State (MMSE) scores, predict the MMSE result based on ACE-III, thus avoiding need for both tests, improving their comparability.Equipercentile equating method was used elaborate table using group of 400 participants comprising healthy controls Alzheimer's disease (AD) patients. Then, reliability assessed in 100 patients with AD, 52 primary progressive aphasia 22...
The Paced Auditory Serial Addition Test (PASAT) is a useful cognitive test in patients with multiple sclerosis (MS), assessing sustained attention and information processing speed. However, the neural underpinnings of performance are controversial. We aimed to study basis PASAT by using structural magnetic resonance imaging (MRI) series 242 MS. (3-s) was administered together comprehensive neuropsychological battery. Global brain volumes total T2-weighted lesion were estimated. Voxel-based...
Background Paced Auditory Serial Addition Test (PASAT) is one of the most used neuropsychological tests in multiple sclerosis (MS), specially for screening. However, applicability test limited because rejection completion a proportion patients. We aimed to investigate clinical, neuropsychological, and MRI findings associated PASAT rejection. Methods Cross-sectional observational study. A total 343 patients with MS underwent testing structural MRI. Results One hundred twenty-one (35.3%)...
Objective: Episodic memory is frequently impaired in Multiple Sclerosis (MS), but the cognitive characteristics and neuropsychological processes involved remain controversial. Our aim was to study episodic dysfunction MS, using LASSI-L, a novel memory-based stress test that uses new paradigm capitalizes on semantic interference. Methods: Cross-sectional which 93 patients with MS (relapsing-remitting) 124 healthy controls were included. The LASSI-L administered all participants, as well...
Abstract Objectives The assessment of social cognition changes may be challenging, especially in the earliest stages some neurodegenerative diseases. Our objective was to validate a battery from multidomain perspective. In this regard, we aimed adapt several tests, collect normative data, and them prodromal Alzheimer’s disease (AD) multiple sclerosis (MS). Methods A total 92 healthy controls, 25 AD, 39 MS patients were enrolled. Age-, gender-, education-matched control groups created for...
Abstract This study of a cohort 1-year treatment-compliant survivors suicide attempt examined for the first time whether high CYP2D6-CYP2C19 metabolic capacity (pharmacogenes related to psychopathology, suicide, and severity) and/or polypharmacy treatments predicted repeat attempts, adjusting sociodemographic clinical factors as confounders. Of 461 (63% women) consecutively hospitalized patients who attempted were evaluated treated after an index attempt, 191 (67.5% attended their 6-...
The Five-Point Test (5PT) is a neuropsychological tool for examining design or figural fluency. In this study, we aimed to provide normative data the 5PT in Spain. Also, compare norms collected our research with other studies from populations evaluate potential cross-cultural application of 5PT. One hundred and ninety-two healthy subjects aged were enrolled. mean age was 68.48 ± 9.68 years old (range 50-89), education 10.65 5.22. There 117 (60.9%) women. overlapping interval strategy used...