A5009875166- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- COVID-19 and Mental Health
- Transcranial Magnetic Stimulation Studies
- Olfactory and Sensory Function Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Text Readability and Simplification
- Spatial Neglect and Hemispheric Dysfunction
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Pharmacological Receptor Mechanisms and Effects
- Sphingolipid Metabolism and Signaling
- Frailty in Older Adults
- Language Development and Disorders
- Protease and Inhibitor Mechanisms
- Alcoholism and Thiamine Deficiency
- SARS-CoV-2 and COVID-19 Research
Hospital Clínico San Carlos
2020-2025
Universidad Complutense de Madrid
2019-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2025
Universidad Autónoma de Madrid
2022-2024
Hôpital Corentin-Celton
2023
Post-COVID syndrome (PCS) is a medical condition characterized by the persistence of wide range symptoms after acute infection SARS-CoV-2. The work capacity consequences this disorder have scarcely been studied. We aimed to analyze factors associated with occupational status in patients PCS. This cross-sectional study involved 77 PCS on active before SARS-CoV-2 infection. Patients were evaluated 20.71 ± 6.50 months clinical onset. conducted survey activity and cognitive symptoms. association...
It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent condition in brain, cerebral small vessel disease (CSVD). The cerebral-coronary connection (C3), a prospective blinded study, investigated prevalence CMD patients artery (CAD) and association CSVD cognitive function.Patients documented CAD fulfilling inclusion criteria underwent physiological assessment epicardial vessels microcirculation using intracoronary pressure Doppler....
Fatigue is one of the most frequent and disabling symptoms post-COVID syndrome. In this study, we aimed to assess effects transcranial direct current stimulation on fatigue severity in a group patients with syndrome chronic fatigue. We conducted double-blind, parallel-group, sham-controlled study evaluate short-term anodal (2 mA, 20 min/day) left dorsolateral prefrontal cortex. The modified impact scale score was used as primary endpoint. Secondary endpoints included cognition (Stroop test),...
Neuropsychological assessment is considered a valid tool in the diagnosis of neurodegenerative disorders. However, there an important overlap cognitive profiles between Alzheimer's disease (AD) and behavioural variant frontotemporal dementia (bvFTD), usefulness uncertain. We aimed to develop machine learning-based models for using tests.
Fatigue is one of the most disabling symptoms in several neurological disorders and has an important cognitive component. However, relationship between self-reported fatigue objective assessment results remains elusive. Patients with post-COVID syndrome often report issues months after acute infection. We aimed to develop predictive models using neuropsychological assessments evaluate results. conducted a cross-sectional study 113 patients syndrome, assessing them Modified Impact Scale...
Abstract Post-COVID condition (PCC) and multiple sclerosis (MS) share some clinical demographic features, including cognitive symptoms fatigue. Some pathophysiological mechanisms well-known in MS, such as autoimmunity, neuroinflammation myelin damage, have also been implicated PCC. In this study, we aimed to compare the phenotypes of two large cohorts patients with PCC evaluate relationship between fatigue performance. Cross-sectional study 218 MS matched by age, sex, years education....
Background Non-invasive brain stimulation has shown positive results in maximizing the effects of language therapy primary progressive aphasia (PPA). Due to different patterns damage each variant, we hypothesized that patients with non-fluent and semantic variants would show a differential response transcranial magnetic (TMS). Objective We aimed compare clinical responses after single session repetitive TMS left inferior frontal gyrus (IFG) dorsolateral prefrontal cortex (DLPC). Methodology...
Background With the changing demographic landscape in most countries worldwide, accurate and brief culture-sensitive case-finding instruments are needed to identify patients with possible cognitive disorders. Objective To investigate discriminative validity of Brief Assessment Impaired Cognition (BASIC) BASIC Questionnaire (BASIC-Q) a multicultural memory clinic sample across six European countries. Methods The study was cross-sectional multi-center study. Receiver operating characteristic...
Background: Verbal fluency (VF) has been associated with several cognitive functions, but the processes underlying verbal deficits in Multiple Sclerosis (MS) are controversial. Further knowledge about VF could be useful clinical practice, because these tasks brief, applicable, and reliable MS patients. In this study, we aimed to evaluate related develop machine-learning algorithms predict those patients using only VF-derived scores. Methods: Two hundred participants were enrolled examined a...
Primary progressive aphasia (PPA) is a neurodegenerative syndrome for which no effective treatment available.We aimed to assess the effect of repetitive transcranial magnetic stimulation (rTMS), using personalized targeting.We conducted randomized, double-blind, pilot study patients with PPA receiving rTMS, subgroup active- versus control-site rTMS in cross-over design. Target active TMS varied among cases and was determined during pre-treatment phase from list potential regions. The primary...
Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different tests that use strategies based assessment language (Mini-Linguistic State Examination, MLSE) or cognitive domains (Addenbrooke's Cognitive ACE-III and Dépistage Cognitif de Québec, DCQ) have proposed independently validated. These aim to detect PPA classify into three main variants (non-fluent (nfvPPA), semantic (svPPA)...
Prior evidence indicates the potential central role of acid sphingomyelinase (ASM)/ceramide system in infection cells with SARS-CoV-2. We conducted a multicenter retrospective observational study including 72,105 adult patients laboratory-confirmed SARS-CoV-2 who were admitted to 36 AP-HP (Assistance Publique-Hôpitaux de Paris) hospitals from 2 May 2020 31 August 2022. examined association between ongoing use medications functionally inhibiting (FIASMA), which reduces vitro, upon hospital...
Background. Primary progressive aphasia (PPA) is a neurodegenerative syndrome in which diagnosis usually challenging. Biomarkers are needed for and monitoring. In this study, we aimed to evaluate Electroencephalography (EEG) as biomarker the of PPA. Methods. We conducted cross-sectional study with 40 PPA patients categorized non-fluent, semantic, logopenic variants, 20 controls. Resting-state EEG 32 channels was acquired preprocessed using several procedures (quantitative EEG, wavelet...
We aimed to evaluate personality traits in patients with post-COVID syndrome, as well the association neuropsychiatric symptoms present this disorder.
Introduction Timely and accurate diagnosis of the earliest manifestations Alzheimer’s disease (AD) is critically important. Cognitive challenge tests such as Loewenstein Acevedo Scales for Semantic Interference Learning (LASSI-L) have shown favorable diagnostic properties in a number previous investigations using amyloid or FDG PET. However, no studies examined LASSI-L performance against cerebrospinal fluid biomarkers AD, which can be affected before distribution fibrillar other changes...
Cognitive processes underlying verbal and design fluency, their neural correlates in patients with Alzheimer's disease (AD) behavioural variant Frontotemporal Dementia (bvFTD) remain unclear. We hypothesised that fluency may be associated distinct neuropsychological AD FTD, showing different patterns of impairment basis.We enrolled 142 participants including (n = 80, mean age 74.71), bvFTD 34, 68.18), healthy controls (HCs) 28, 71.14), underwent cognitive assessment 18F-fluorodeoxyglucose...
The Cross-Cultural Dementia (CCD) is a new screening tool to evaluate cognitive impairment based on cross-cultural perspective reduce the bias of education, and language cultural differences. We aimed diagnostic properties CCD in Spaniards for assessment patients with Alzheimer's disease mild (AD-MCI) dementia stages (AD-D) associated Parkinson's (PD-MCI).Sixty participants AD (50% MCI) thirty PD-MCI were enrolled. Each clinical group was compared against healthy control (HC) same number no...
Objectives: We aimed to evaluate and compare the diagnostic capacity of five cognitive screening tests for diagnosis mild impairment (MCI) in patients consulting by memory loss. Methods: A cross-sectional study involving 140 participants with a mean age 74.42 ± 7.60 years, 87 (62.14%) women. Patients were classified as MCI or cognitively unimpaired according comprehensive neuropsychological battery. The properties following compared: Mini-Mental State Examination (MMSE), Addenbrooke’s...
To examine the association between psychiatric and non-psychiatric comorbidity 28-day mortality among patients with disorders COVID-19.We performed a multicenter observational retrospective cohort study of adult hospitalized laboratory-confirmed COVID-19 at 36 Greater Paris University hospitals (January 2020-May 2021) (N=3,768). First, we searched for different subgroups according to their comorbidities through cluster analysis. Next, compared all-cause rates across identified clusters,...
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.To examine connectivity differences between RIS healthy controls using magnetic resonance imaging (fMRI).Resting-state fMRI data 25 28 were analyzed independent component analysis; addition, seed-based correlation analysis was used to obtain more...