A5014635995- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Neurogenetic and Muscular Disorders Research
- Neurobiology of Language and Bilingualism
- Long-Term Effects of COVID-19
- Macrophage Migration Inhibitory Factor
- Cognitive Functions and Memory
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Cerebrovascular and genetic disorders
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- RNA Interference and Gene Delivery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Multiple Sclerosis Research Studies
- Biochemical Acid Research Studies
- Bipolar Disorder and Treatment
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
Hospital Clínico San Carlos
2022-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022-2025
Universidad Complutense de Madrid
2022-2025
Mary Lyon Centre at MRC Harwell
2023
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as "TDP-43 proteinopathies". Aggregates of are present the brains and spinal cords >97% amyotrophic lateral sclerosis (ALS), ∼50% frontotemporal dementia (FTD) patients. While mutations gene (TARDBP) usually associated with ALS, many clinical reports have linked these cognitive impairments and/or FTD, but also other disorders including Parkinsonism (PD) or progressive supranuclear palsy (PSP). a...
Abstract Post-COVID condition (PCC) and multiple sclerosis (MS) share some clinical demographic features, including cognitive symptoms fatigue. Some pathophysiological mechanisms well-known in MS, such as autoimmunity, neuroinflammation myelin damage, have also been implicated PCC. In this study, we aimed to compare the phenotypes of two large cohorts patients with PCC evaluate relationship between fatigue performance. Cross-sectional study 218 MS matched by age, sex, years education....
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence aberrant, misfolded and mislocalized deposits protein TDP-43, as in case amyotrophic lateral sclerosis some, but not all, pathological variants frontotemporal dementia. In recent years, many other diseases have been reported to primary or secondary proteinopathy, such Alzheimer's disease, Huntington's disease recently described limbic-predominant age-related encephalopathy, highlighting...
Background/Objectives: Fatigue is a prevalent and debilitating symptom in Post-COVID Condition (PCC), fibromyalgia, multiple sclerosis (MS). Although these conditions share clinical similarities, the underlying mechanisms of fatigue across may differ remain poorly understood. This study aimed to compare intensity characteristics three identify shared distinct features. Methods: We conducted cross-sectional involving 429 participants: 219 with PCC, 112 98 MS. Participants completed...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients animal models. Leptin, an adipose-derived hormone, displays altered levels ALS. Genetically reducing leptin (Lepob/+) to maintain body improved motor performance extended survival female SOD1G93A mice, although the exact molecular mechanisms behind these effects remain elusive. Here, we corroborated...
Introduction Timely and accurate diagnosis of the earliest manifestations Alzheimer’s disease (AD) is critically important. Cognitive challenge tests such as Loewenstein Acevedo Scales for Semantic Interference Learning (LASSI-L) have shown favorable diagnostic properties in a number previous investigations using amyloid or FDG PET. However, no studies examined LASSI-L performance against cerebrospinal fluid biomarkers AD, which can be affected before distribution fibrillar other changes...
Background The Cross-Cultural Neuropsychological Test Battery (CNTB) is a novel test battery specifically designed to reduce the impact of multiculturality in cognitive assessment. Objective We aimed validate CNTB Spaniards patients with Alzheimer's disease (AD), including at mild impairment (MCI) and dementia stages, Parkinson's MCI (PD-MCI). Methods Thirty AD-MCI, 30 AD-dementia (AD-D), PD-MCI were recruited. Each clinical group was compared against healthy control (HC) no differences sex,...
Objectives: We aimed to evaluate and compare the diagnostic capacity of five cognitive screening tests for diagnosis mild impairment (MCI) in patients consulting by memory loss. Methods: A cross-sectional study involving 140 participants with a mean age 74.42 ± 7.60 years, 87 (62.14%) women. Patients were classified as MCI or cognitively unimpaired according comprehensive neuropsychological battery. The properties following compared: Mini-Mental State Examination (MMSE), Addenbrooke’s...
Introduction The Addenbrooke’s Cognitive Examination III (ACE-III) is a brief test useful for neuropsychological assessment. Several studies have validated the diagnosis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, we aimed to examine metabolic correlates associated with performance ACE-III in AD behavioral variant FTD. Methods We enrolled 300 participants cross-sectional including 180 patients AD, 60 FTD (bvFTD), controls. An 18 F-Fluorodeoxyglucose positron...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients animal models. Leptin, an adipose-derived hormone, displays altered levels ALS. Genetically reducing leptin ( Lep ob/+) to maintain body improved motor performance extended survival female SOD1 G93A mice, although the exact molecular mechanisms behind these effects remain elusive. Here, we...
Abstract Background The Cross‐Cultural Neuropsychological Test Battery (CNTB) is a novel comprehensive neuropsychological battery developed from multicultural approach. We aimed to validate the CNTB in patients majority population with Alzheimer’s disease (AD), including mild cognitive impairment (MCI) and dementia stages, Parkinson’s MCI (PD‐MCI). Methods Thirty AD‐MCI, 30 AD‐dementia (AD‐D), PD‐MCI were enrolled. Each clinical group had specific healthy control (HC) no differences sex,...
Abstract TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of are present the brains and spinal cords >97% amyotrophic lateral sclerosis (ALS), ∼50% frontotemporal dementia (FTD) patients. While mutations gene ( TARDBP ) usually associated with ALS, many clinical reports have linked these cognitive impairments and/or FTD, but also other disorders including Parkinsonism (PD) or progressive supranuclear palsy...