A5016811941- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Olfactory and Sensory Function Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Infectious Encephalopathies and Encephalitis
- Psychosomatic Disorders and Their Treatments
- Neurobiology of Language and Bilingualism
- Medical research and treatments
- Advanced Chemical Sensor Technologies
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Developmental and Educational Neuropsychology
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Fibroblast Growth Factor Research
Hospital Clínico San Carlos
2021-2025
Universidad Complutense de Madrid
2021-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2022
Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However, limited literature exists about brain alterations post-COVID syndrome, a condition increasingly associated with cognitive impairment. The present study aimed to evaluate functional and structural patients assess whether these were related dysfunction. Eighty-six syndrome 36 healthy controls recruited underwent neuroimaging acquisition comprehensive neuropsychological assessment. Cognitive examinations...
Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence this symptom and potential relationship with central nervous system involvement unknown.To evaluate neural correlates persistent olfactory in a series patients post-COVID syndrome.Eighty-two syndrome were assessed Brief Smell Identification Test multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, arterial spin labeling. neuroimaging examinations performed 11.18 ± 3.78...
Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, vivo detailed evaluation of hippocampal changes PCS patients, validated on post-mortem samples at acute phase, would shed light into relationship between cognition.Hippocampal subfields volume, microstructure, perfusion were evaluated 84 compared 33 controls....
Fatigue is one of the most disabling symptoms in several neurological disorders and has an important cognitive component. However, relationship between self-reported fatigue objective assessment results remains elusive. Patients with post-COVID syndrome often report issues months after acute infection. We aimed to develop predictive models using neuropsychological assessments evaluate results. conducted a cross-sectional study 113 patients syndrome, assessing them Modified Impact Scale...
Cognitive symptoms after COVID-19 have been increasingly recognized several months the acute infection and designated as "brain fog." We report a patient with cognitive that started immediately COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer's disease. Our case highlights need to examine patients following comprehensively. A detailed assessment combining clinical, cognitive, biomarker studies may help disentangle underlying mechanisms associated...
We aimed to evaluate personality traits in patients with post-COVID syndrome, as well the association neuropsychiatric symptoms present this disorder.
FGFR3-TACC3 fusion-positive IDH-wild-type (IDH-WT) glioblastoma (GB) is a rare GB subtype occurring in approximately 3% of cases. It clinical behavior and molecular profile different from those fusion-negative IDH-WT GBs. Evidence on the role FGFR inhibitors FGFR-altered gliomas limited. We present case patient with that at its second recurrence was treated inhibitor erdafitinib through compassionate use program. Although no objective response achieved, an overt deceleration tumor growth...
Abstract Objective . Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the of dysfunction in reporting complaints after COVID-19 evaluate correlation between function anxiety, depression, sleep, olfactory function. Methods Cross-sectional involving 50 with 9.12±3.46 months acute infection. Patients were evaluated a comprehensive...
Neurological manifestations associated with SARS-CoV-2 infection as well its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit persistently depressed mental status and leukoencephalopathy. discuss clinical radiological findings also propose possible involved.
Abstract Background . We aimed to evaluate personality traits in patients with post-COVID syndrome, as well the association neuropsychiatric symptoms present this disorder. Methods The Big Five Structure Inventory was administered 93 consecutive a diagnosis of syndrome and matched controls. also performed comprehensive evaluation depression, anxiety, fatigue, sleep quality, cognitive function, olfactory function. Results Patients scored lower for emotional stability, equanimity, positive...
Abstract Background. We aimed to evaluate personality traits in patients with postCOVID syndrome, as well the association neuropsychiatric symptoms present this disorder. Methods. The Big Five Structure Inventory was administered 93 consecutive a diagnosis of post-COVID syndrome and matched controls. also performed comprehensive evaluation depression, anxiety, fatigue, sleep quality, cognitive function, olfactory function. Results. Patients scored lower for emotional stability, equanimity,...