A5091446208- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Effects of Radiation Exposure
- Spinal Hematomas and Complications
- Anesthesia and Pain Management
- Family Support in Illness
- Peripheral Neuropathies and Disorders
- Whipple's Disease and Interleukins
- Radiation Dose and Imaging
- Advanced Neuroimaging Techniques and Applications
- Neurological and metabolic disorders
- Mycobacterium research and diagnosis
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Gene expression and cancer classification
- Autoimmune and Inflammatory Disorders Research
- Medical Imaging Techniques and Applications
- Pericarditis and Cardiac Tamponade
- Vestibular and auditory disorders
- Ultrasound Imaging and Elastography
Research Institute Hospital 12 de Octubre
2012-2024
Hospital Universitario 12 De Octubre
2011-2024
Universidad Complutense de Madrid
2011-2014
Biomedical Research Networking Center on Neurodegenerative Diseases
2014
Up until now, no information has existed regarding a comparison of the pattern and frequency cognitive deficits between radiologically isolated syndrome (RIS) clinically (CIS) patients. Within this objective, Rao’s Brief Repeatable Battery Stroop test were administered to 28 RIS patients, 25 CIS 22 healthy controls. Conclusions: The prevalence in was similar that CIS. Cognitive seem be present patients regardless presence risk factors for future symptomatic demyelinating event.
Alemtuzumab is a high-efficacy treatment approved for relapsing-remitting multiple sclerosis (RRMS). Although clinical trials and observational studies are consistent in showing its efficacy manageable safety profile, further under practice conditions needed to support use. The aim of this retrospective study was evaluate the effectiveness alemtuzumab add current real-world evidence on drug. A cohort 115 adult patients with RRMS treated between 2014 2020 retrospectively followed up five...
The unanticipated magnetic resonance imaging (MRI) detection in the brain of asymptomatic subjects white matter lesions suggestive multiple sclerosis has recently been named as radiologically isolated syndrome (RIS). pathophysiological processes RIS remain largely unknown and questions to whether gray alterations actually occur this entity are yet be investigated more detail. By means a 3 T multimodal MRI approach, we searched for cortical deep changes cohort patients. Seventeen patients, 17...
Background: Little information exists about how cognitive impairment in multiple sclerosis (MS) patients impacts on their caregivers’ health-related quality of life (HRQoL). The objective this paper is to examine the extent which MS contributes HRQoL. Methods: A total 63 patients, caregivers and 59 matched controls were recruited. Patients underwent a neuropsychological assessment, including tests working memory, speed processing, executive function, verbal fluency. HRQoL was assessed by...
Background and purpose: The unanticipated detection by magnetic resonance imaging (MRI) in the brain of asymptomatic subjects white matter lesions suggestive multiple sclerosis (MS) has been named radiologically isolated syndrome (RIS). As difference between early MS [i.e. clinically (CIS)] RIS is occurrence a clinical event, it logical to improve subclinical form without interfering with MRI as there are radiological diagnostic criteria for that. Our objective was use machine-learning...
To date, it remains largely unknown whether there is in radiologically isolated syndrome (RIS) brain damage beyond visible T2 white matter lesions. We used single- voxel proton magnetic resonance spectroscopy and diffusion tensor imaging (3 T MRI) to analyze normal-appearing tissue regions 18 RIS patients matched healthy controls. T2-hyperintense lesion volumes structural were also measured. The absolute metabolite concentrations ratios of total N-acetylaspartate+N-acetylaspartyl glutamate...
Given that tremor is one of the most prevalent and disabling features multiple sclerosis (MS), we will review significant milestones in this disease recent years, focusing on prevalence, clinical features, anatomical basis, treatment.Data for were identified by searching MEDLINE with search terms "multiple sclerosis" "tremor". References also from relevant articles published between January 1966 May 2012.The predominant type MS a large-amplitude, postural, kinetic tremor, which commonly...
<strong>Background:</strong> Given that tremor is one of the most prevalent and disabling features multiple sclerosis (MS), we will review significant milestones in this disease recent years, focusing on prevalence, clinical features, anatomical basis, treatment. <strong>Methods:</strong> Data for were identified by searching MEDLINE with search terms ‘‘multiple sclerosis’’ ‘‘tremor’’. References also from relevant articles published between January 1966 May 2012. <strong>Results:</strong>...
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.To examine connectivity differences between RIS healthy controls using magnetic resonance imaging (fMRI).Resting-state fMRI data 25 28 were analyzed independent component analysis; addition, seed-based correlation analysis was used to obtain more...
OPINION article Front. Neurol., 01 September 2022Sec. Multiple Sclerosis and Neuroimmunology https://doi.org/10.3389/fneur.2022.995690
Orthostatic tremor is a rare kind of which clinically characterised by feeling instability or being about to fall that experienced on standing up, disappears improves walking and absent when sitting lying down.To shed light the main features this syndrome.First, its clinical spectrum defined, with emphasis key characteristics enable us make an initial approximation syndromes. Then neurophysiological up electromyographic profile orthostatic are described. Finally, pathophysiological...
There is evidence of the presence a disturbed pattern anger in multiple sclerosis (MS). Emotion changes, including anger, are thought to influence health-related quality life (HRQoL). However, although deleterious consequences on physical health have been well reported, there no studies that analysed effects HRQoL patients with MS. Our purpose was assess extent which impacts cohort MS patients.One hundred and fifty-seven consecutive were enrolled study. Participants administered affective...