A5042872757- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Gut microbiota and health
- Glycogen Storage Diseases and Myoclonus
- Ophthalmology and Eye Disorders
- Ultrasound Imaging and Elastography
- Hereditary Neurological Disorders
- SARS-CoV-2 and COVID-19 Research
- Myofascial pain diagnosis and treatment
- Peripheral Neuropathies and Disorders
- Tryptophan and brain disorders
- Medical and Biological Ozone Research
- Identity, Memory, and Therapy
- Attention Deficit Hyperactivity Disorder
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Gastrointestinal motility and disorders
- Vestibular and auditory disorders
- Migraine and Headache Studies
- Photoreceptor and optogenetics research
Research Institute Hospital 12 de Octubre
2016-2023
Hospital General Universitario de Ciudad Real
2022
Hospital Universitario 12 De Octubre
2013-2018
<strong>Background:</strong> Orthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson’s disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss findings main case series on OT, including data etiology, pathophysiology, diagnostic approach, treatment strategies, outcome. <strong>Methods:</strong> Data for review were identified by searching PUBMED...
<h3>Objective</h3> To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. <h3>Methods</h3> Retrospective multicenter registry patients MS suspected or confirmed diagnosis available disease course (mild = ambulatory; severe hospitalization; critical intensive care unit/death). Cases were analyzed for associations between identifying risk...
Abstract Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these are related to cognitive deficits, which been described ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial (AD), and radial measures were compared between 23 patients age-, gender-, education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of with scores...
The unanticipated magnetic resonance imaging (MRI) detection in the brain of asymptomatic subjects white matter lesions suggestive multiple sclerosis has recently been named as radiologically isolated syndrome (RIS). pathophysiological processes RIS remain largely unknown and questions to whether gray alterations actually occur this entity are yet be investigated more detail. By means a 3 T multimodal MRI approach, we searched for cortical deep changes cohort patients. Seventeen patients, 17...
Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patients might deficits in specific aspects neuropsychological function, particularly those thought to rely on integrity prefrontal cortex, which suggests a possible involvement frontocerebellar circuits. examined whether resting-state functional magnetic resonance imaging (fMRI) provide further insights into OT. Resting-state fMRI data 13 (11 women and 2 men) matched healthy controls were...
Background and purpose: The unanticipated detection by magnetic resonance imaging (MRI) in the brain of asymptomatic subjects white matter lesions suggestive multiple sclerosis (MS) has been named radiologically isolated syndrome (RIS). As difference between early MS [i.e. clinically (CIS)] RIS is occurrence a clinical event, it logical to improve subclinical form without interfering with MRI as there are radiological diagnostic criteria for that. Our objective was use machine-learning...
To date, it remains largely unknown whether there is in radiologically isolated syndrome (RIS) brain damage beyond visible T2 white matter lesions. We used single- voxel proton magnetic resonance spectroscopy and diffusion tensor imaging (3 T MRI) to analyze normal-appearing tissue regions 18 RIS patients matched healthy controls. T2-hyperintense lesion volumes structural were also measured. The absolute metabolite concentrations ratios of total N-acetylaspartate+N-acetylaspartyl glutamate...
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.To examine connectivity differences between RIS healthy controls using magnetic resonance imaging (fMRI).Resting-state fMRI data 25 28 were analyzed independent component analysis; addition, seed-based correlation analysis was used to obtain more...
Background Eyelid nystagmus is a rare clinical phenomenon described mostly related to brainstem or cerebellum lesions. The mechanism of this incompletely understood. Patients and Methods We report 2 cases eyelid induced by carbamazepine oxcarbazepine intoxication. Conclusions Carbamazepine derivatives may induce in the setting acute To best our knowledge, these are first drug-related nystagmus.
Despite the importance of cognitive function in multiple sclerosis, it is poorly represented Expanded Disability Status Scale (EDSS), commonly used clinical measure to assess disability, suggesting that an analysis eye movement, which generated by extensive and well-coordinated functional network engaged function, could have potential extend complement this more conventional measure. We aimed movement a case series MS patients with relapsing−remitting their status using gaze tracker. A total...
Evidence regarding the relationship between performance on specific cognitive domains and cause of death is scarce. We assessed whether predicted mortality presence any association with causes in a population-dwelling sample non-demented ol der adults. In this population-based, prospective study (NEDICES), 2,390 subjects ≥65 years completed brief neuropsychological battery. Cox's proportional hazards models, adjusted by sociodemographic comorbidity factors, global performance, educational...
Domingo-Santos, Ángela MD; Sepúlveda, María; Matarazzo, Michele; Calleja-Castaño, Patricia; Ramos-González, Ana; Saiz, Albert; Benito-León, Julián Author Information