A5070150597- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Neutropenia and Cancer Infections
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Bacterial Identification and Susceptibility Testing
- Cerebral Palsy and Movement Disorders
- Voice and Speech Disorders
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neural Engineering
- Assistive Technology in Communication and Mobility
- Transcranial Magnetic Stimulation Studies
- Frailty in Older Adults
- Neurobiology of Language and Bilingualism
- Advanced Sensor and Energy Harvesting Materials
- Cardiovascular Syncope and Autonomic Disorders
- Restless Legs Syndrome Research
- Health disparities and outcomes
- Dysphagia Assessment and Management
University Hospital HM Puerta del Sur
2016-2025
Universidad San Pablo CEU
2016-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2012-2025
Hospital Universitario 12 De Octubre
2011-2025
Comunidad de Madrid
2025
Universidad Complutense de Madrid
2011-2024
Instituto de Salud Carlos III
2012-2024
Research Institute Hospital 12 de Octubre
2011-2023
HM Hospitales
2015-2023
Centro de Investigación Biomédica en Red
2013-2023
Abstract α‐Synuclein inclusions have been identified in the brain and some parts of enteric nervous system Parkinson's disease cases. We aimed to assess these gastric mucosa samples from patients with symptomatic disease. Random biopsies were performed by gastroscopy 28 29 age‐ sex‐matched controls. Gastroscopy was start enteral levodopa ( l ‐dopa) therapy cases for diagnostic purposes controls (gastroesophageal reflux, anemia, abdominal pain main indications). The clinical definition made a...
Mobile technology is opening a wide range of opportunities for transforming the standard care chronic disorders. Using smartphones as tools longitudinally tracking symptoms could enable personalization drug regimens and improve patient monitoring. Parkinson's disease (PD) an ideal candidate these tools. At present, evaluation PD signs requires trained experts to quantify motor impairment in clinic, limiting frequency quality information available understanding status progression disease. can...
Accurate blood-based biomarkers of Alzheimer's disease (AD) could constitute simple, inexpensive, and non-invasive tools for the early diagnosis treatment this devastating neurodegenerative disease. We sought to develop a robust AD biomarker p
Parkinson's disease (PD) is a slowly progressing neurodegenerative with early manifestation of motor signs. Objective measurements signs are vital importance for diagnosing, monitoring and developing modifying therapies, particularly the stages when putative neuroprotective treatments could stop neurodegeneration. Current medical practice has limited tools to routinely monitor PD enough frequency without undue burden patients healthcare system. In this paper, we present data indicating that...
Inertial measurement units (IMUs) positioned on various body locations allow detailed gait analysis even under unconstrained conditions. From a medical perspective, the assessment of vulnerable populations is particular relevance, especially in daily-life environment. Gait algorithms need thorough validation, as many chronic diseases show specific and unique patterns. The aim this study was therefore to validate an acceleration-based step detection algorithm for patients with Parkinson's...
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...
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Orthostatic hypotension (OH) is a common and disabling symptom affecting Parkinson's disease (PD) patients. We present the effect of different therapies commonly used to manage PD on this clinical manifestation. For purpose, we describe relationship between OH current treatments employed in PD, such as L-DOPA, dopaminergic agonists, continuous stimulation therapies. Additionally, review therapeutic measures that could be ameliorate OH. There are approaches deal with manifestation, including...
Background: Parkinson's disease (PD) is the second most prevalent neurodegenerative and one of common forms movement disorder. Although there no known cure for PD, existing therapies can provide effective symptomatic relief. However, optimal titration crucial to avoid adverse effects. Today, decision making PD management challenging because it relies on subjective clinical evaluations that require a visit clinic. This challenge has motivated recent research initiatives develop tools be used...
Abstract Many disease symptoms restrict the quality of life affected. This usually occurs indirectly, at least in most neurological diseases. Here, impaired daily function is interposed between and reduced life. reflected International Classification Function, Disability Health model published by World Organization 2001. correlation symptom, function, makes it clear that to evaluate success a therapy develop new therapies, must also be evaluated as accurately possible. However, complex...
ABSTRACT Objective To define the motor onset and progression of Parkinson's disease (PD) in a prospective cohort early unmedicated patients. Methods We enrolled consecutive recently diagnosed (<18 months) PD patients with unilateral manifestations using age gender‐matched controls. The most affected body region was determined various clinical standard metrics objective quantitative kinematic measurements. Progression Markers Initiative data were used for external validation results....
The striatal dopaminergic deficit in Parkinson's disease exhibits a typical pattern, extending from the caudal and dorsal putamen at onset to its more rostral region as progresses. Clinically, upper-limb of cardinal motor features is rule. Thus, according current understanding somatotopy (i.e. lower limb upper limb) assumed pattern early denervation does not fit with an onset. We have examined topography putaminal cohort 23 recently diagnosed de novo patients 19 age-/gender-matched healthy...
Background Expiratory muscle strength training (EMST) is acknowledged for its therapeutic benefits in Parkinson's disease (PD), yet long-term adherence remains a challenge. Objective The primary aim of this study was to assess the preliminary effects EMST coupled with mobile health app (SpiroGym) on self-efficacy and exercise PD patients. secondary usability SpiroGym app. Methods This single-group, multicenter, multinational proof-of-concept involved 63 patients across four tertiary centers....
Background and objective Device-aided therapies (DATs) are treatments indicated for people with Parkinson´s disease (PwP) experiencing clinical fluctuations that remain suboptimal despite conventional medication. New DATs have recently emerged such as levodopa-entacapone-carbidopa intestinal gel infusion (LECIG) subcutaneous of foslevodopa/foscarbidopa (fLD/fCD). Understanding the differences between various is essential. Patients Methods We present here protocol study DATs-PD GETM Spanish...
Abstract Modern digital devices and appliances are capable of monitoring the timing button presses, or finger interactions in general, with a sub-millisecond accuracy. However, massive amount high resolution temporal information that these could collect is currently being discarded. Multiple studies have shown act pressing triggers well defined brain areas which known to be affected by motor-compromised conditions. In this study, we demonstrate daily interaction computer keyboard can...
Objectively measuring the response to therapy is an unmet need in management of Parkinson's disease (PD). The Unified Disease Rating Scale1 and, specifically, its motor subscale (UPDRS-III), most widely used evaluation tool. Traditionally, a statistically significant difference with comparative group (e.g., placebo) has been employed identify effective therapies. More recently, concept minimal clinically important (MCID) gaining momentum as means avoid relying on statistical differences that...