A5004745128- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Pharmacological Effects and Toxicity Studies
- Vestibular and auditory disorders
- Long-Term Effects of COVID-19
- Ophthalmology and Eye Disorders
- Advanced MRI Techniques and Applications
- Neurological diseases and metabolism
- Olfactory and Sensory Function Studies
- Cerebral Venous Sinus Thrombosis
- Balance, Gait, and Falls Prevention
- Obsessive-Compulsive Spectrum Disorders
- Assistive Technology in Communication and Mobility
- Trigeminal Neuralgia and Treatments
- Ion channel regulation and function
- Healthcare cost, quality, practices
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
Universidad San Pablo CEU
2019-2024
HM Hospitales
2021-2024
University Hospital HM Puerta del Sur
2018-2024
Northwestern University
2021-2024
Ottawa University
2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022
Hospital Clínico San Carlos
2020-2022
Universidad Autónoma de Madrid
2018-2021
Instituto de Salud Carlos III
2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2021
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...
ABSTRACT Objective To define the motor onset and progression of Parkinson's disease (PD) in a prospective cohort early unmedicated patients. Methods We enrolled consecutive recently diagnosed (<18 months) PD patients with unilateral manifestations using age gender‐matched controls. The most affected body region was determined various clinical standard metrics objective quantitative kinematic measurements. Progression Markers Initiative data were used for external validation results....
The striatal dopaminergic deficit in Parkinson's disease exhibits a typical pattern, extending from the caudal and dorsal putamen at onset to its more rostral region as progresses. Clinically, upper-limb of cardinal motor features is rule. Thus, according current understanding somatotopy (i.e. lower limb upper limb) assumed pattern early denervation does not fit with an onset. We have examined topography putaminal cohort 23 recently diagnosed de novo patients 19 age-/gender-matched healthy...
•MRgFUS is an FDA approved, incisionless, therapy for the treatment of ET and PD.•RCTs MRgFUS targeting VIM, GPi STN demonstrate benefit.•Case series PTT also suggest significant benefit.•Low-intensity can transiently open BBB.•Future technical developments studies will further define role MRgFUS. The surgical movement disorders, primarily tremor, started with radiofrequency lesioning globus pallidus thalamus in 1950s [[1]Hassler R. Riechert T. Symptomatology & surgery extrapyramidal...
Objective: This study aimed to prove the concept of a new optical video-based system measure Parkinson's disease (PD) remotely using an accessible standard webcam. Methods: We consecutively enrolled cohort 42 patients with PD and healthy subjects (HSs). The participants were recorded performing MDS-UPDRS III bradykinesia upper limb tasks computer video frames processed artificial intelligence algorithms tracking movements hands. extracted features correlated clinical rating Movement Disorder...
Directional subthalamic stimulation in Parkinson's disease can increase threshold for adverse effects and widen the therapeutic window. However, selection of programming settings is time consuming, requiring a thorough monopolar clinical review. To overcome this, may be guided by intraoperatively recording local field potential beta oscillations (13-35 Hz).1) Evaluate whether power recorded predict clinically most effective directional contacts; 2) assess long-term outcomes between patients...
Abstract Neuromelanin‐containing dopaminergic neurons in the substantia nigra pars compacta (SNpc) are most vulnerable Parkinson's disease (PD). Recent work suggests that accumulation of oxidized dopamine and neuromelanin mediate convergence mitochondrial lysosomal dysfunction patient‐derived neurons. In addition, expression human tyrosinase mouse SNpc led to formation resulting degeneration nigral neurons, further highlighting importance PD. The potential role PD pathogenesis has been...
The differential vulnerability of dopaminergic neurons the substantia nigra pars compacta (SNc) is a critical and unresolved question in Parkinson´s disease. Studies mice show diverse susceptibility subpopulations nigral to various toxic agents. In primate midbrain, molecular phenotypes their are poorly characterized. We performed detailed histological study determine anatomical distribution different within identified midbrain selective control MPTP-treated monkeys. ventral tier SNc...
Abstract Background Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations PD. The primate thalamus is densely heterogeneously innervated with dopaminergic axons, most of which express dopamine transporter, as does nigrostriatal system. We hypothesized that depletion may present parkinsonian brain set out to ascertain possible regional differences. Methods toxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine was administered...
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and a profound reduction striatal dopamine are two hallmarks Parkinson's disease (PD). However, it's unclear whether degeneration starts at neuronal soma or presynaptic terminals, how microstructural is linked to loss also uncertain. In this study, thirty de novo PD patients twenty healthy subjects (HS) underwent 6-[18F]-fluoro-L-dopa (FDOPA) PET MRI studies no later than 12 months from clinical diagnosis. FDOPA uptake...
Deep brain stimulation (DBS) is widely used for treatment of advanced, medication-refractory Parkinson's disease (PD). However, a significant proportion patients may suffer adverse effects; up to 10% will present one or more transient permanent neurobehavioral events.In our case study, 44-year-old woman diagnosed with PD 6 years previously who was suffering from motor fluctuations, dyskinesia, and freezing gait episodes submitted DBS implanted directional electrodes. Intraoperative local...
The healthcare model is shifting towards integrated care approaches. This new requires patients to be more closely involved. iCARE-PD project aims address this need by developing a technology-enabled, home-based, and community-centered paradigm. A central part of the codesign process care, exemplified active participation in design iterative evaluation three sensor-based technological solutions. We proposed methodology used for testing usability acceptability these digital technologies...
Abstract Cerebral venous sinus thrombosis (CVST) is a cause of secondary headache with substantial morbimortality. Headache dominates the clinical presentation, but no typical phenotype has been described. We aim to evaluate presence red flags in patients confirmed CVST at moment emergency department (ED) presentation. Retrospective STROBE compliant cohort study including that consulted because ED. analyzed and type consult. evaluated whether was suspected imaging request delay diagnosis....
STAT-ON™ is an objective tool that registers ON-OFF fluctuations making possible to know the state of patient at every moment day in normal life. Our aim was analyze opinion different Parkinson's disease experts about after using device a real clinical practice setting (RCPS).
The field of neuroscience is increasingly dominated by a preferred use big data, where analysis large numbers has become an essential area development. We here draw attention to the importance smaller numbers, and more specifically, historical continued detailed judiciously performed studies in single healthy volunteers or patients with unique clinical presentation, as important approach study normal functions nervous system, understand pathophysiology underlying neurological movement...
Medicine is becoming increasingly digital with widespread use of electronic devices including tablets, smartphones, and online platforms for collecting health-related data.1 The digitalization medicine has the potential to reduce burden care make standard clinical data available in real-time research purposes2, 3 while lowering study duration costs. One consequence this adaptation validated paper-based scales (e-scales). International Parkinson's Disease Movement Disorders Society (MDS) led...