A5047969875- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Spinal Cord Injury Research
- Visual perception and processing mechanisms
- Motor Control and Adaptation
- Neural Networks and Applications
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Nerve injury and regeneration
- Pain Management and Treatment
- Sleep and Wakefulness Research
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Vestibular and auditory disorders
- Blind Source Separation Techniques
University Hospital HM Puerta del Sur
2016-2025
Hospital Nacional de Parapléjicos
2015-2025
Instituto de Salud Carlos III
2020-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2025
HM Hospitales
2020-2025
Servicio de Salud de Castilla La Mancha
2015-2024
Universidad San Pablo CEU
2014-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2002-2018
Ospedale Maggiore
2002-2018
University of Toronto
2018
<h3>Objectives</h3> To assess the feasibility and clinical efficacy of local field potentials (LFPs)–based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease (PD) during daily activities an open-label, nonblinded study. <h3>Methods</h3> We monitored neurophysiologic fluctuations 2 perioperative experimental sessions lasting for up to 8 hours. On first day, patient took his/her medication, while on second, he/she additionally underwent subthalamic nucleus aDBS...
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
Despite several studies and models, much remains unclear about how the human basal ganglia operate. Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for complicated Parkinson's disease, but DBS acts also unknown. The clinical benefit at frequencies >100 Hz suggests possible importance neural rhythms operating higher than range normally considered processing (<100 Hz). electrodes implanted offer opportunity to record activity from ganglia. This study aimed...
Event-related changes of brain electrical rhythms are typically analysed as amplitude modulations local field potential (LFP) oscillations, like radio modulation broadcasting. In telecommunications, frequency (FM) is less susceptible to interference than (AM) and therefore preferred for high-fidelity transmissions. Here we hypothesized that LFP detected from deep stimulation (DBS) electrodes implanted in the subthalamic nucleus (STN) patients with Parkinson's disease could represent...
Fast ripples are a type of transient high-frequency oscillations recorded from the epileptogenic regions hippocampus and temporal cortex epileptic humans rodents. These events presumably reflect hypersynchronous bursting pyramidal cells. However, oscillatory spectral content fast varies 250 to 800 Hz, well above maximal firing frequency most hippocampal neurons. How such generated is therefore unclear. Here, we combine computational simulations with multisite juxtacellular recordings in vivo...
Non‐Technical Summary Non‐invasive neuromodulation of the human brain – with pulsed magnetic fields or small direct currents is becoming increasingly popular for treating a variety neurological and neuropsychiatric disorders. In present work we investigated in healthy humans possibility non‐invasive modulation motor cortex excitability by application static through scalp. We found that transcranial field stimulation (tSMS) can reduce period outlasts time field. Moreover, demonstrated these...
Spinal cord injury can produce extensive long-term reorganization of the cerebral cortex. Little is known, however, about sequence cortical events starting immediately after lesion. Here we show that a complete thoracic transection spinal produces immediate functional in primary somatosensory cortex anesthetized rats. Besides obvious loss responses to hindpaw stimuli (below level lesion), evoked by forepaw (above lesion) markedly increase. Importantly, these increased correlate with slower...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
The basic information architecture in the basal ganglia circuit is under debate. Whereas anatomical studies quantify extensive convergence/divergence patterns circuit, suggesting an sharing scheme, neurophysiological report absence of linear correlation between single neurones normal animals, a segregated parallel processing scheme. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys and parkinsonian patients become linearly correlated, thus leading to loss segregation...
The clinical efficacy of high-frequency deep brain stimulation (DBS) for Parkinson's disease and other neuropsychiatric disorders likely depends on the modulation neuronal rhythms in target nuclei. This could be effectively measured with local field potential (LFP) recordings during DBS. However, a technical drawback that prevents LFPs from being recorded DBS nuclei is stimulus artefact. To solve this problem, we designed developed 'FilterDBS', an electronic amplification system...