A5049363727- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Ultrasound and Hyperthermia Applications
- Restless Legs Syndrome Research
- Motor Control and Adaptation
- Ultrasound Imaging and Elastography
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neuroscience and Neural Engineering
- Public Health and Nutrition
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
University Hospital HM Puerta del Sur
2019-2024
HM Hospitales
2020-2024
Instituto Cajal
2021-2024
Universidad Autónoma de Madrid
2022-2024
Universidad San Pablo CEU
2019-2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2023
Instituto de Salud Carlos III
2021-2022
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
Unilateral magnetic resonance imaging (MRI)-guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored.
Abstract Focal application of a strong static magnetic field over the human scalp induces measurable local changes in brain function. Whether it also distant effects across and how these collectively affect motor behavior remains unclear. Here we applied transcranial stimulation (tSMS) supplementary area (SMA) healthy subjects. At behavioral level, tSMS increased time to initiate movement while decreasing errors choice reaction-time tasks. functional SMA resting-state fMRI activity bilateral...
Abstract The amplitude of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) is a common yet highly variable measure corticospinal excitability. tradeoff between maximizing the number trials and minimizing experimental time remains hurdle. It therefore important to establish how many should be used. aim this study not provide rule-of-thumb answers that may valid only in specific conditions, but offer more general framework inform decision about use under...
Background Unilateral focused ultrasound subthalamotomy (FUS-STN) improves motor features of Parkinson’s disease (PD) in moderately advanced patients. The less invasive nature FUS makes its early application PD feasible. We aim to assess the safety and efficacy unilateral FUS-STN patients with than 5 years from diagnosis (early PD). Methods Prospective, open-label study. Eligible had highly asymmetrical cardinal features. primary outcome was safety, defined as treatment-related adverse...
Cognitive reserve (CR) is the mismatch between preserved cognition and neuropathological damage. Amyloidopathy in Parkinson's disease (PD) could be associated with faster progression to dementia, but putative protective effect of CR unknown.
Essential tremor (ET) is the most common movement disorder, affecting 1% of population worldwide. There sound evidence that medically refractory improves with thalamotomy and deep brain stimulation (DBS) targeting thalamic ventralis intermedius nucleus (VIM). In last few years, incisionless technique magnetic resonance-guided focused ultrasound (MRgFUS) has been demonstrated to be an effective procedure for unilateral thalamotomy,1 a positive profile regard side effects. The thalamus...
Mild cognitive impairment (MCI) is a relevant non-motor feature in Parkinson’s disease (PD). Social cognition (SC) domain that refers to the ability decode others’ intentions and guide behavior social contexts. We aimed compare SC performance mid-stage PD patients compared healthy population according their state. Fifty-two were classified as being cognitively normal (PD-CN) or having mild (PD-MCI) following Movement Disorder Society (MDS) Level II criteria. assessment included facial...
Abstract The SMA is fundamental in planning voluntary movements and execution of some cognitive control operations. Specifically, the has been known to play a dominant role controlling goal-directed actions as well those that are highly predicted (i.e., automatic). Yet, essential contribution or automatic behavior scarce. Our objective was test possible direct response inhibition. We separately applied two noninvasive brain stimulation (NIBS) inhibitory techniques over SMA: either continuous...
Social cognition (SC) encompasses a set of cognitive functions that enable individuals to understand and respond appropriately social interactions. Although focused ultrasound subthalamotomy (FUS-STN) effectively treats Parkinson's disease (PD) clinical motor features, its impact safety on cognitive-behavioral interactions/interpersonal awareness are unknown. This study investigated the effects unilateral FUS-STN facial emotion recognition (FER) affective theory mind (ToM) in PD patients...
Abstract The dorsolateral striatum plays a critical role in the acquisition and expression of stimulus-response habits that are learned experimental laboratories. Here, we use meta-analytic procedures to contrast neural circuits activated by laboratory-acquired with those behaviours acquired everyday-life. We confirmed newly rely more on anterior putamen activation extending into caudate nucleus accumbens. Motor associative components everyday-life were identified. found motor-dominant...
The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT has been associated with conversion to PD; however, results are conflicting since some studies did not find strong influence. Cortical hypometabolism cognitive impairment in PD. In this study, we aimed evaluate the metabolic pattern nondemented PD patients H1/H1 carriers comparison H1/H2 haplotype. addition, evaluated...
Abstract Objective Depression is one of the most disabling non-motor symptoms in Parkinson’s disease (PD) and requires proper diagnosis as it negatively impacts patients’ their relatives quality life. The present study aimed to examine psychometric diagnostic properties Beck Inventory-I (BDI-I) a Spanish PD cohort. Method Consecutive outpatients completed version BDI-I other questionnaires assessing anxiety apathy. Patients’ caregivers depression/dysphoria domain Neuropsychiatric Inventory...
To evaluate safety and feasibility of MR guided focused ultrasound (MRgFUS)-blood brain barrier (BBB) opening in PDD putative changes cognition PET.