A5049186987- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Ultrasound and Hyperthermia Applications
- Neurological diseases and metabolism
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Iron Metabolism and Disorders
- Ultrasound Imaging and Elastography
- Liver Disease and Transplantation
- Barrier Structure and Function Studies
- Radiation Therapy and Dosimetry
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neurological and metabolic disorders
- Liver Disease Diagnosis and Treatment
- Autism Spectrum Disorder Research
University Hospital HM Puerta del Sur
2019-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2023-2025
Instituto de Salud Carlos III
2023-2025
HM Hospitales
2019-2025
Universidad Complutense de Madrid
2019-2025
Centro de Investigación Biomédica en Red
2023-2025
Research Network (United States)
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2019
Iron deposition in the nigrostriatal system plays a pivotal role Parkinson's disease (PD) onset and progression. This study explored time course of iron accumulation 54 PD patients at early to moderately advanced stages 20 age-matched healthy controls. Using multi-echo T2*-MRI R2* relaxometry, content was assessed substantia nigra pars compacta (SNpc) striatum. In vivo findings were contrasted with histological analyses progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced...
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and a profound reduction striatal dopamine are two hallmarks Parkinson's disease (PD). However, it's unclear whether degeneration starts at neuronal soma or presynaptic terminals, how microstructural is linked to loss also uncertain. In this study, thirty de novo PD patients twenty healthy subjects (HS) underwent 6-[18F]-fluoro-L-dopa (FDOPA) PET MRI studies no later than 12 months from clinical diagnosis. FDOPA uptake...
Purpose Clinical treatment planning protocols for protons recommend a uniform value radiobiological effectiveness (RBE) of 1.1 throughout the field, despite evidence from in‐vitro and animal studies that proton RBE increases with linear energy transfer (LET), causing tissues placed distally to target location receive presumably higher biological dose than estimated. While several voices in medical physics community have advocated variable RBE‐based optimization, uncertainties models...
Low-intensity focused ultrasound (LIFU) combined with intravenously circulating microbubbles has recently emerged as a novel approach for increasing delivery through the blood-brain barrier (BBB). This technique safely and transiently enables therapeutic agents to overcome BBB, which typically poses significant obstacle treatment of brain disorders. However, full impact LIFU on entire neurovascular unit (NVU), well mechanisms factors involved in restoring BBB integrity still require further...
FDOPA uptake rate, fractional volume of free-water and R2* relaxometry are imaging biomarkers sensitive to dopaminergic decline, microstructural degeneration, iron disruption respectively, three pathological processes developed within the nigrostriatal system in Parkinson’s disease (PD). A multimodal comprehensive characterization these early PD was performed, assessing them striatum substantia nigra pars compacta a de novo cohort. While not observed, subjects revealed alterations system,...
Iron has an important role in Parkinson’s disease (PD) pathophysiology. However, it is still uncertain how iron accumulates within the nigrostriatal circuit along with PD progression. Here we assessed content from early to moderate stages using R2* relaxometry, and histologically a macaque MPTP (1-metil-4-fenil6-tetrahidropiridina) model. Our analyses revealed that both human model, progressively SNpc during stages, reaching plateau before PD. Meanwhile, followed V-shaped progression...
Preprocessing protocol for structural, DWI and T2* MRI acquisitions
The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT has been associated with conversion to PD; however, results are conflicting since some studies did not find strong influence. Cortical hypometabolism cognitive impairment in PD. In this study, we aimed evaluate the metabolic pattern nondemented PD patients H1/H1 carriers comparison H1/H2 haplotype. addition, evaluated...