Carlos Ordás
A5079482873- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Myofascial pain diagnosis and treatment
- Restless Legs Syndrome Research
- Ophthalmology and Eye Disorders
- Psychosomatic Disorders and Their Treatments
- Ginkgo biloba and Cashew Applications
- Musculoskeletal pain and rehabilitation
- Sympathectomy and Hyperhidrosis Treatments
- Pain Management and Placebo Effect
- Dysphagia Assessment and Management
- Dementia and Cognitive Impairment Research
- Medical and Biological Sciences
- Balance, Gait, and Falls Prevention
- Neurological and metabolic disorders
- Autism Spectrum Disorder Research
- Suicide and Self-Harm Studies
- Neuroscience of respiration and sleep
- Neurological Complications and Syndromes
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects and Toxicity Studies
- Autoimmune Neurological Disorders and Treatments
Hospital Universitario Rey Juan Carlos
2016-2025
Universidad Rey Juan Carlos
2017-2025
Hospital General Universitario Gregorio Marañón
2023
Instituto de Salud Carlos III
2023
Centro de Investigación Biomédica en Red de Salud Mental
2023
Universidad Complutense de Madrid
2016-2023
Hospital Universitario de La Princesa
2023
Italfarmaco (Italy)
2021
Zambon (Italy)
2021
Lundbeck (Germany)
2021
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The role of musculoskeletal disorders the cervical spine in migraine is under debate.To investigate differences impairments neck including active global and upper mobility, presence symptomatic joints, cervicocephalic kinesthesia head/neck posture between women with episodic migraine, chronic controls.A cross-sectional study.Tertiary university-based hospital.Fifty-five 16 22 matched healthy women.Active range motion, mobility (i.e., flexion-rotation test), referred pain from (joint position...
To investigate widespread pressure hyperalgesia in the trigemino-cervical and extra-trigeminal (distant pain-free) regions women with episodic chronic migraine.Fifty-one migraine, 52 healthy without headache history were recruited. Pressure pain thresholds (PPT) bilaterally assessed over trigeminal area (i.e., temporalis muscle), cervical C5/C6 zygapophyseal joint), two areas second metacarpal, tibialis anterior muscle) a blinded design. Clinical features of migraine anxiety/depression...
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients Methods: PD who were recruited from the cohort COPPADIS January 2016 to November 2017 included. A cross-sectional two-year follow-up analysis conducted. Univariate analyses general linear model repeated measure used. Results: At baseline, data 681 (mean age 62.54 ± 8.93) fit criteria for analysis. Of them, 410 (60.2%) males 271...
Quality of life (QOL) plays an important role in independent living Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course disease. Here we identified predictors impairment PD patients from a Spanish cohort. recruited 35 centers Spain COPPADIS cohort January 2016, November 2017, were followed up during 2 years. Health-related (HRQoL) and global (GQoL) assessed with 39-item Questionnaire (PDQ-39) EUROHIS-QOL 8-item index (EUROHIS-QOL8),...
Previous studies have demonstrated the presence of active trigger points (TrPs) in women with migraine reproducing their headache attacks. No study has investigated whether these TrPs can alter cervical muscle function migraine. Our objective was to analyze differences activation superficial neck flexor and extensor muscles considering splenius capitis (SC), upper trapezius (UT), sternocleidomastoid (SCM) muscles.Surface electromyography (EMG) recorded from flexors (SCM anterior scalene)...
Epicrania fugax (EF) is a primary headache of recent description. We aimed to report 19 new cases EF, and thus contribute the characterization this emerging headache.EF characterized by painful paroxysms starting in particular area head, rapidly radiating forwards or backwards through territories different nerves. The pain felt quick motion along lineal zigzag trajectory. To date, 47 have been published, 34 with forward EF 13 backward EF.We performed descriptive study all attending our...
Objective To investigate the association between trigger points (TrPs) and widespread pressure pain sensitivity in people with tension-type headache (TTH) to determine if this is different frequent episodic (FETTH) or chronic (CTTH) headache. Design A cross-sectional study. Methods One hundred fifty-seven individuals (29% male) TTH participated. Clinical features of headache, i.e., intensity, duration, frequency, were recorded a diary. Active latent TrPs bilaterally explored temporalis,...
Symptomatic trigeminal neuralgia due to a brainstem infarction is said be rare. However, facial pain not uncommon in Wallenberg's syndrome. Facial related syndrome may either persistent of intermittent, and occasionally occurs brief attacks. Here, we report patient with right lateral medullary who started having first division 1 month after the stroke. The paroxysms were suppressed gabapentin.
Introduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow know the course of disease. Our aim was analyze whether scale combining Hoehn and Yahr’s motor stage (H&Y) nonmotor symptoms burden (NMSB) (assessed by (NMSS)) provides information about disability patient’s quality life (QoL) with regard defined stage. Materials Methods. Cross-sectional study in which 603 PD patients from COPPADIS cohort were classified...
Abstract Background and Objective Caregiver burden in Parkinson's disease (PD) has been studied many cross‐sectional studies but poorly longitudinal ones. The aim of the present study was to analyze change burden, strain, mood, quality life (QoL) after a 2‐year follow‐up cohort caregivers patients with PD also identify predictors these changes. Patients Methods their who were recruited from January/2016 November/2017 35 centers Spain COPPADIS included study. They evaluated again at...
Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD).
Constipation has been linked to cognitive impairment development in Parkinson's disease (PD).Our aim was analyze changes observed PD patients and controls from a Spanish cohort with regards the presence or not of constipation.PD recruited 35 centers Spain COPPADIS January 2016 November 2017 were followed-up during 2 years. The change status baseline (V0) 2-year follow-up assessed PD-CRS (Parkinson's Disease Cognitive Rating Scale). Subjects score ≥1 on item 21 NMSS (Non-Motor Symptoms Scale)...
The objective of this study was to investigate differences in clinical, psychological, and psychophysical outcomes according use prophylactic medication (amitriptyline) tension-type headache (TTH).In total, 173 individuals with TTH participated. Headache features symptomatic intake were collected a 4-weeks diary at baseline 6-months. Burden (Headache Disability Inventory-HDI), sleep quality (Pittsburgh Sleep Quality Index-PSQI), anxiety/depression (Hospital Anxiety Depression Scale-HADS),...
Successful preventive treatment in chronic migraine (CM) remains an unmet need some cases, and new therapeutic strategies are emerging. We aimed to test the effect of noninvasive, transcutaneous supraorbital nerve stimulation (tSNS) a group patients with CM.This was open label, quasi-experimental design. Twenty-five CM were recruited from two hospital headache clinics. After one-month baseline period, monthly visits scheduled during three months. Headache occurrence, its intensity,...
Cuando tras una correcta anamnesis y exploración neurológica se diagnostica a un paciente con cefalea primaria o neuralgia craneofacial en urgencias atención decide derivar neurología por complejidad es útil conocer si además deberían solicitar exploraciones complementarias la preferencia (urgente, preferente normal) que debería para el llegue consulta del neurólogo sin demoras innecesarias pacientes dolores incapacitantes sospecha de organicidad. Por este motivo, Grupo Estudio Cefalea...
The SORL1 gene encodes a protein involved in the amyloidogenic process, and its variants have been associated with Alzheimer's disease (AD) physiopathology. We screened for 124 familial (44 early- 80 late-onset) dementia of Alzheimer type (DAT) cases. Nine potentially pathogenic changes (three not previously reported six rare variants) were found nine probands (7%). After screening control population siblings (presence at least 1/200 controls and/or absence segregation pattern), causal...
Abstract The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) subjects (CS) as well relationship between ICDs/CBs motor, nonmotor features dopaminergic treatment PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used validated Questionnaire for Impulsive-Compulsive Disorders Parkinson's Disease-Rating Scale (QUIP-RS) ICD/CB screening....