Darrian McAfee
A5053894263- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Ginkgo biloba and Cashew Applications
- Dementia and Cognitive Impairment Research
- Dysphagia Assessment and Management
- Pharmacological Effects and Toxicity Studies
- Balance, Gait, and Falls Prevention
- Parkinson's Disease and Spinal Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Obsessive-Compulsive Spectrum Disorders
- Child Nutrition and Feeding Issues
- Assistive Technology in Communication and Mobility
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Suicide and Self-Harm Studies
University of Maryland, Baltimore
2021-2025
University of Pennsylvania
2020-2025
Center for the Neural Basis of Cognition
2021-2025
Ohio University
2024
Memorial Sloan Kettering Cancer Center
2024
Emory University
2024
National Institutes of Health
2024
National Institute of Neurological Disorders and Stroke
2024
Complejo Hospitalario de Navarra
2023
University of Maryland, College Park
2023
Background and purpose The objective of this study was to analyze the relationship between motor complications non‐motor symptom (NMS) burden in a population patients with Parkinson’s disease (PD) also subgroup early PD. Methods Patients PD from COPPADIS cohort were included cross‐sectional study. NMS defined according Non‐Motor Symptoms Scale (NMSS) total score. Unified Disease Rating (UPDRS) part IV used establish complication types their severity. ≤5 years symptoms onset as Results Of 690...
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients Methods: PD who were recruited from the cohort COPPADIS January 2016 to November 2017 included. A cross-sectional two-year follow-up analysis conducted. Univariate analyses general linear model repeated measure used. Results: At baseline, data 681 (mean age 62.54 ± 8.93) fit criteria for analysis. Of them, 410 (60.2%) males 271...
Abstract Objective Pentylenetetrazol (PTZ) kindling is a widely used model for inducing epileptogenesis and evaluating long-term seizure susceptibility differences among animals. This typically performed by chronic, repetitive exposures to constant subconvulsive PTZ dose. However, the effectiveness of commonly dose (35mg/kg) varies different animal groups experimental conditions due factors such as species, age, sex, genetic background. The objective this study was characterize novel...
ABSTRACT The field of neuromodulation lacks predictors individual differences in plasticity that influence responses to repetitive transcranial magnetic stimulation (rTMS). Continuous theta burst (cTBS), a form rTMS known for its inhibitory effects, shows variable between individuals, potentially due neuroplasticity. Predicting cTBS effects could vastly enhance clinical and experimental utility. This study explores whether motor evoked potential (MEP) input-output (IO) parameters measured...
5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson's disease (PD). The aim the present study is to compare quality life (QoL) in PD patients with "5-2-1 positive criteria" vs QoL without (defined as meeting ≥1 criteria).
Quality of life (QOL) plays an important role in independent living Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course disease. Here we identified predictors impairment PD patients from a Spanish cohort. recruited 35 centers Spain COPPADIS cohort January 2016, November 2017, were followed up during 2 years. Health-related (HRQoL) and global (GQoL) assessed with 39-item Questionnaire (PDQ-39) EUROHIS-QOL 8-item index (EUROHIS-QOL8),...
Abstract Background and Objective Caregiver burden in Parkinson's disease (PD) has been studied many cross‐sectional studies but poorly longitudinal ones. The aim of the present study was to analyze change burden, strain, mood, quality life (QoL) after a 2‐year follow‐up cohort caregivers patients with PD also identify predictors these changes. Patients Methods their who were recruited from January/2016 November/2017 35 centers Spain COPPADIS included study. They evaluated again at...
Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD).
Constipation has been linked to cognitive impairment development in Parkinson's disease (PD).Our aim was analyze changes observed PD patients and controls from a Spanish cohort with regards the presence or not of constipation.PD recruited 35 centers Spain COPPADIS January 2016 November 2017 were followed-up during 2 years. The change status baseline (V0) 2-year follow-up assessed PD-CRS (Parkinson's Disease Cognitive Rating Scale). Subjects score ≥1 on item 21 NMSS (Non-Motor Symptoms Scale)...
Abstract The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) subjects (CS) as well relationship between ICDs/CBs motor, nonmotor features dopaminergic treatment PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used validated Questionnaire for Impulsive-Compulsive Disorders Parkinson's Disease-Rating Scale (QUIP-RS) ICD/CB screening....
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze change global NMS burden a PD cohort after 2-year follow-up, (2) compare changes with control group, (3) identify predictors progression group. Material Methods: patients controls, recruited from 35 centers Spain COPPADIS January 2016 November 2017, were followed-up 2 years. Non-Motor Symptoms Scale (NMSS) administered at...
The aim of this study was to compare the progression independence in activities daily living (ADL) Parkinson's disease (PD) patients versus a control group, as well identify predictors disability and functional dependency (FD).
ABSTRACT Background Levodopa‐induced dyskinesias (LID) are frequent in Parkinson's disease (PD). Objective To analyze the change frequency of LID over time, identify related factors, and characterize how impact on patients’ quality life (QoL). Patients Methods PD patients from 5‐year follow‐up COPPADIS cohort were included. defined as a non‐zero score item “Time spent with dyskinesia” Unified Disease Rating Scale—part IV (UPDRS‐IV). The UPDRS‐IV was applied at baseline (V0) annually for 5...
Epilepsy is a common neurological disorder, affecting over 65 million people worldwide. Unfortunately, despite resective surgery, 30 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m1"><mml:mi>%</mml:mi></mml:math> of patients with drug-resistant epilepsy continue to experience seizures. Retrospective studies considering connectivity using intracranial electrocorticography (ECoG) obtained during neuromonitoring have shown that treatment failure likely driven by consider critical...
Objective: The aim of the present study was to analyze progression non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding development motor fluctuations (MF). Methods: PD without MF at baseline, who were recruited from January 2016 November 2017 (V0) and evaluated again a 2-year follow-up (V2) 35 centers Spain COPPADIS cohort, included this analysis. V2 defined as score ≥ 1 item-39 UPDRS-Part IV, whereas NMS according Non-motor Symptoms Scale (NMSS) total score....
Background and Purpose Visual hallucinations (VH) subjective cognitive complaints (SCC) are associated with impairment (CI) in Parkinson's disease.Our aims were to determine the association between VH SCC risk of CI development a cohort patients disease normal cognition (PD-NC).Methods Patients PD-NC (total score >80 on Disease Cognitive Rating Scale [PD-CRS]) recruited from Spanish COPPADIS January 2016 November 2017 followed up after 2 years.Subjects ≥1 domain 5 item 13 Non-Motor Symptoms...
Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling a PD cohort and compare it with control group. Specifically, we identified factors associated conducted subanalyses subgroup very early patients. Patients Methods. patients who were recruited from January 2016 November 2017 (baseline visit; V0) evaluated again at 2-year ± 30-day follow-up (V2) 35 centers Spain COPPADIS included this longitudinal...
Abstract Background and objective Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non‐motor, cognition, dependency) five stages, correlated severity patients’ quality of life. Here, analyzed the correlation MNCD PD caregiver's status. Patients methods Data from baseline visit patients their principal caregiver recruited 35 centers in Spain COPPADIS cohort January 2016 to November 2017 were used apply...
Abstract Background Although depression is known to be frequent in Parkinson's disease (PD), it unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was analyze the frequency depression, related factors and contribution a QoL perception regard duration. Methods PD patients recruited from COPPADIS cohort January 2016 November 2017 were included this cross‐sectional study. Three groups defined: <5 years (Group A); 5 <10 B); ≥10 C). Analysis with...