A5002552733- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Medical Imaging and Pathology Studies
- Cancer Treatment and Pharmacology
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Cerebral Palsy and Movement Disorders
- HIV/AIDS drug development and treatment
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Soft tissue tumor case studies
- Analog and Mixed-Signal Circuit Design
- Pulmonary Hypertension Research and Treatments
- Dysphagia Assessment and Management
- Sleep and related disorders
- Transplantation: Methods and Outcomes
- RNA modifications and cancer
- Parkinson's Disease and Spinal Disorders
- Economic and Financial Impacts of Cancer
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
Hospital Clínico San Carlos
1998-2020
Hospital Universitario Dexeus
2017
Universidad de Navarra
1993-2017
National Institute of Neurological Disorders and Stroke
1998
National Institutes of Health
1998
The brain regions activated by simple repetitive and sequential finger movements of different length were localized measuring regional cerebral blood flow (rCBF) with PET. experimental design consisted cued auditory pacing at 0.5 Hz. In all conditions sequence the contralateral primary sensorimotor premotor cortex, supplementary motor area ipsilateral cerebellar cortex activated. These areas showed a large increase in activation from rest to movement, further shortest sequence, suggesting an...
Background and purpose The objective of this study was to analyze the relationship between motor complications non‐motor symptom (NMS) burden in a population patients with Parkinson’s disease (PD) also subgroup early PD. Methods Patients PD from COPPADIS cohort were included cross‐sectional study. NMS defined according Non‐Motor Symptoms Scale (NMSS) total score. Unified Disease Rating (UPDRS) part IV used establish complication types their severity. ≤5 years symptoms onset as Results Of 690...
Background and purpose In Parkinson's disease ( PD ), the course of disorder is highly variable between patients. Well‐designed, prospective studies for identifying progression biomarkers are necessary. Our aim was to show results baseline evaluations an ongoing global project, COPPADIS ‐2015 Co hort Patients with PA rkinson's DI sease in Spain, 2015). Methods This observational, descriptive, nationwide study (Spain). The recruitment period ended October 2017. Baseline evaluation included...
The aim of the present study was to examine frequency self-reported sleep problems and their associated factors in a large cohort PD patients.PD patients controls, recruited from 35 centers Spain COPPADIS were included this cross-sectional study. Sleep assessed by Spanish version Parkinson's disease Scale 1 (PDSS-1). An overall score below 82 or 5 on at least item defined as problems.The nearly double compared controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS lower...
Purpose: To validate the Parkinson's Fatigue Scale (PFS-16) in advanced Parkinson Disease (APD) patients using scale's Spanish version. Patients and methods: In a clinical study for Levodopa-Carbidopa Intestinal Gel (LCIG), 59 were assessed over six months PFS-16 other instruments. The psychometric properties of then analyzed. Results: (60.7% men) aged 68.02±7.43 years. PD duration was 12.57±5.97 Median Hoehn Yahr (HY) stage "on" 2 (range: 1-4). There excellent data quality acceptability as...
Studies on focal dystonia showed that the formulations of botulinum toxin type A, incobotulinumtoxin-A (Inco-BTA) and onabotulinumtoxin-A (Ona-BTA), have equivalent efficacy safety.To carry-out a cost-utility analysis Inco-BTA administered flexible intervals vs. Ona-BTA fixed interval, in treatment blepharospasm cervical dystonia.A probabilistic Markov model was designed to estimate costs (euros, 2017) benefits (quality-adjusted life years, QALY), from Spanish National Health Service...
Tuberous sclerosis (TS) is a rare disease of the nervous system, being characterized by seizures, mental retardation and adenoma sebaceum. Concomitant pleuropulmonary lesions spontaneous pneumothorax are extremely during evolution this disease. To date, only 19 cases TS have been described in literature. Here we present case associated with 29-year-old female patient. Clinical, roentgenographic histological aspects commented upon.
Sumatriptán es un potente agonista serotoninérgico selectivo de los receptores 5HT1D vasculares. 
 está indicado en el tratamiento agudo migraña y no se recomienda su utilización como agente profiláctico.
 Aunque mecanismo acción conoce detalladamente sabe que por una parte produce vasoconstricción selectiva a nivel la circulación carotídea otra bloquea liberación sustancias vasodilatadoras origen neurógeno, disminuyendo extravasación plasmática consiguiente inflamación neurógena...
Comparar las características de los pacientes con enfermedad Parkinson avanzada en tratamiento infusión intestinal continua levodopa-carbidopa (IICLC) y datos efectividad seguridad IICLC entre diferentes comunidades autónomas (CC. AA.). Estudio longitudinal observacional retrospectivo. Se incluyeron 177 11 CC. AA. que iniciaron enero 2006 diciembre 2011. compararon clínicas demográficas, variables (cambios el tiempo OFF, ON sin discinesias discapacitantes, cambios la escala Hoehn Yahr...
To compare the characteristics of patients undergoing treatment with continuous intestinal infusion levodopa–carbidopa (CIILC) for advanced Parkinson's disease and data on effectiveness safety CIILC in different autonomous communities (AC) Spain. A retrospective, longitudinal, observational study was carried out into 177 from 11 CAs who underwent between January 2006 December 2011. We analysed patients' clinical demographic characteristics, variables related to (changes off time/on time or...