A5063649880- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Acute Lymphoblastic Leukemia research
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Health and Medical Education
- Rheumatoid Arthritis Research and Therapies
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Delphi Technique in Research
- Hereditary Neurological Disorders
- Mycobacterium research and diagnosis
- Healthcare professionals’ stress and burnout
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Parkinson's Disease Mechanisms and Treatments
- Health, psychology, and well-being
Hospital Clínico Universitario de Valladolid
2021-2024
<b>Background: </b> There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment the course disease. <b>Methods: Using data from two large longitudinal databases, authors tested whether cross-sectional assessments are representative disease severity as whole. An algorithm, Multiple Sclerosis Severity Score (MSSS), which relates scores on Expanded Disability Status Scale (EDSS) to...
<h3>Objective</h3> To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. <h3>Methods</h3> Retrospective multicenter registry patients MS suspected or confirmed diagnosis available disease course (mild = ambulatory; severe hospitalization; critical intensive care unit/death). Cases were analyzed for associations between identifying risk...
Introduction and objective Limited information is available on how neurologists make therapeutic decisions in neuromyelitis optica spectrum disorder (NMOSD), especially when new treatments with different mechanisms of action, administration, safety profile are being approved. Decision-making can be complex under this uncertainty may lead to inertia (TI), which refers lack treatment initiation or intensification goals not met. The study aim was assess neurologists’ TI NMOSD. Methods An...
The study's aim was to assess the importance given by neurologists bodily functions of patients with neuromyelitis optica spectrum disorder (NMOSD).
Severe cases of lymphopenia have been reported during siponimod clinical trials, which may negatively impact its benefit/risk profile.We aimed to evaluate the incidence following initiation treatment in practice. The secondary objectives included analysis factors predisposing and relevance events.In this multicenter retrospective cohort study, information collected from medical records 129 patients with MS 15 tertiary hospitals Spain who initiated Siponimod were followed-up for at least 3...
The EMCOVID project conducted a multi-centre cohort study to investigate the impact of COVID-19 on patients with Multiple Sclerosis (pwMS) receiving disease-modifying therapies (DMTs). aimed evaluate seroprevalence and persistence SARS-CoV-2 antibodies in MS enrolled database. DMTs were used manage by reducing relapses, lesion accumulation, disability progression. However, concerns arose regarding susceptibility pwMS due potential interactions between immune system, as well immunomodulatory...
Development.This first part includes the latest results regarding impact of environment and lifestyle on risk MS its clinical course, role epigenetics genetic factors these processes.Findings from preclinical research lymphocyte subtypes identified involvement lymphoid follicles meningeal in disease are discussed.Changes brain structure addressed at microscopic macroscopic levels, including high-resolution imaging techniques.The advances biomarkers for diagnosis prognosis MS, microbiome...