A5011415422- Acute Lymphoblastic Leukemia research
- Pharmacogenetics and Drug Metabolism
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Pain Management and Opioid Use
- Helicobacter pylori-related gastroenterology studies
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Gastroesophageal reflux and treatments
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Drug-Induced Adverse Reactions
- Opioid Use Disorder Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Veterinary Pharmacology and Anesthesia
- Renin-Angiotensin System Studies
- Cardiac and Coronary Surgery Techniques
- Maternal and fetal healthcare
- Fungal Infections and Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Reproductive Health and Contraception
- Childhood Cancer Survivors' Quality of Life
- Maternal Mental Health During Pregnancy and Postpartum
- Multiple Sclerosis Research Studies
Hospital Universitario de La Princesa
2022-2023
Universidad Autónoma de Madrid
2022-2023
Thiopurine drugs are purine nucleoside analogues used for treatment of different immune-related conditions. To date, studies highlighted the importance thiopurine methyltransferase (TPMT) genotyping in patients who initiate with thiopurines to make an adequate dose adjustment. We aimed investigate influence TPMT phenotype, concomitant treatments, and demographic characteristics on incidence adverse reactions (ADRs) start azathioprine (AZA). This was observational retrospective study. The...
Rivaroxaban is a direct inhibitor of factor Xa, member oral anticoagulant group drugs (DOACs). Despite being widely extended alternative to vitamin K antagonists (i.e., acenocoumarol, warfarin) the interindividual variability DOACs significant, and may be related adverse drug reaction occurrence or inefficacy, namely hemorrhagic thromboembolic events. Since there not consistent analytic practice monitor activity DOACs, previously reported polymorphisms in genes coding for proteins...
Abstract Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy gastroesophageal reflux disease. In this study, we aimed to explore impact relevant variants in CYP3A4 CYP2C8 other pharmacogenes, along with demographic characteristics, on cinitapride pharmacokinetics safety; evaluate alleles enzyme's function. Twenty‐five healthy volunteers participating bioequivalence clinical trial consented participate study....
A cost analysis of thiopurine treatment was carried out in 257 patients, with 153 preemptively genotyped for TPMT and 104 retrospectively a Spanish setting. The healthcare significantly higher patients compared to those who were (p < 0.001). intermediate metabolizers (IMs) (n = 23) showed 3.3-fold when normal (NMs) IM phenotype whose physician adhered the genotype-informed recommendation similar than NMs lower IMs did not adhere therapeutic (3.8-fold, p 0.016). Myelotoxicity occurrence vs....
Severe cases of lymphopenia have been reported during siponimod clinical trials, which may negatively impact its benefit/risk profile.We aimed to evaluate the incidence following initiation treatment in practice. The secondary objectives included analysis factors predisposing and relevance events.In this multicenter retrospective cohort study, information collected from medical records 129 patients with MS 15 tertiary hospitals Spain who initiated Siponimod were followed-up for at least 3...
To estimate the prevalence of use progestin-only contraceptive among women who request reversible contraception in Primary Care (PC).Multicentre cross-sectional study.Primary Health Centres (Madrid).Women aged 16-50 years old, users contraception, speak Spanish, and had attended Centre last year.Primary outcome: method used: Contraception with progestins-only (yes/no). Age, parity, country origin, type used, reason for choice, source information, satisfaction method. Telephone survey.A total...
Background —Adverse drug reactions (ADRs) are a public health issue, due to their great impact on morbidity, mortality, and economic cost. The use of automatized laboratory alerts could simplify greatly its detection. Objectives —We aimed evaluate the performance system as method for detecting ADRs, using hyponatremia rhabdomyolysis case studies. Methods —This is retrospective observational study conducted in 2019 during 6-month period, including patients hospitalized at Hospital...
Abstract Background Severe cases of lymphopenia have been reported during siponimod clinical trials, which may negatively impact its benefit/risk profile. Objective To evaluate the incidence first 3–6 months treatment in practice. Secondary objectives include analyses factors predisposing to and relevance events. Methods In this multicenter retrospective cohort study, collected information from medical records 129 patients with MS, 15 tertiary hospitals Spain, who initiated siponimod, were...
Tramadol is an important minor opioid prescribed for pain management. In this study, we analyzed the well-known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5, CYP3A4) on tramadol efficacy safety. Some 108 patients with after surgery admitted to a post-anesthesia care unit (PACU) were recruited. They genotyped, M1/M2 metabolite concentrations determined by newly validated HPLC-MS/MS method....