A5048656301- Acute Lymphoblastic Leukemia research
- Gastroesophageal reflux and treatments
- Prenatal Screening and Diagnostics
- Pain Management and Opioid Use
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Helicobacter pylori-related gastroenterology studies
- Opioid Use Disorder Treatment
- Veterinary Pharmacology and Anesthesia
- Pregnancy and Medication Impact
- Childhood Cancer Survivors' Quality of Life
Universidad Autónoma de Madrid
2022-2023
Hospital Universitario de La Princesa
2022-2023
Zero to Three
2023
Thiopurine drugs are purine nucleoside analogues used for treatment of different immune-related conditions. To date, studies highlighted the importance thiopurine methyltransferase (TPMT) genotyping in patients who initiate with thiopurines to make an adequate dose adjustment. We aimed investigate influence TPMT phenotype, concomitant treatments, and demographic characteristics on incidence adverse reactions (ADRs) start azathioprine (AZA). This was observational retrospective study. The...
Abstract Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy gastroesophageal reflux disease. In this study, we aimed to explore impact relevant variants in CYP3A4 CYP2C8 other pharmacogenes, along with demographic characteristics, on cinitapride pharmacokinetics safety; evaluate alleles enzyme's function. Twenty‐five healthy volunteers participating bioequivalence clinical trial consented participate study....
A cost analysis of thiopurine treatment was carried out in 257 patients, with 153 preemptively genotyped for TPMT and 104 retrospectively a Spanish setting. The healthcare significantly higher patients compared to those who were (p < 0.001). intermediate metabolizers (IMs) (n = 23) showed 3.3-fold when normal (NMs) IM phenotype whose physician adhered the genotype-informed recommendation similar than NMs lower IMs did not adhere therapeutic (3.8-fold, p 0.016). Myelotoxicity occurrence vs....
Tramadol is an important minor opioid prescribed for pain management. In this study, we analyzed the well-known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5, CYP3A4) on tramadol efficacy safety. Some 108 patients with after surgery admitted to a post-anesthesia care unit (PACU) were recruited. They genotyped, M1/M2 metabolite concentrations determined by newly validated HPLC-MS/MS method....