A5026681178- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Pharmacological Effects and Toxicity Studies
- SARS-CoV-2 and COVID-19 Research
- Epilepsy research and treatment
- Computational Drug Discovery Methods
- COVID-19 Clinical Research Studies
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Chronic Lymphocytic Leukemia Research
- Diabetes Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Pain Management and Opioid Use
- Estrogen and related hormone effects
- Pharmacology and Obesity Treatment
- Statistical Methods in Clinical Trials
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Opioid Use Disorder Treatment
PharmaMar (Spain)
2024-2025
Hospital Universitario de La Princesa
2018-2025
Universidad Autónoma de Madrid
2018-2025
Mercy Research
2022-2023
Zero to Three
2020-2023
Spanish Clinical Research Network
2020-2022
Instituto de Salud Carlos III
2020-2022
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2021-2022
Centre for Biomedical Network Research on Rare Diseases
2022
Universidad de Alcalá
2020
Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on pharmacokinetic parameters (PK) several substrates. included 251 healthy volunteers who received a single dose ambrisentan, atorvastatin, imatinib, aripiprazole, fentanyl, amlodipine, donepezil, olanzapine, fesoterodine, or quetiapine. The genotyped for CYP3A4 and CYP3A5 by qPCR. To compare PK across studies, measurements corrected mean each...
Abstract P‐glycoprotein, encoded by ABCB 1 , is an ATP ‐dependent drug efflux pump which exports substances outside the cell. Some studies described connections between C3435T polymorphism T allele and lower P‐glycoprotein expression; therefore, homozygous T/T could show higher plasma levels. Our aim was to evaluate effect of on pharmacokinetics 4 antipsychotics (olanzapine, quetiapine, risperidone aripiprazole) antidepressants (trazodone, sertraline, agomelatine citalopram). The study...
Fentanyl is an agonist of the μ-opioid receptor commonly used in treatment moderate-severe pain. In order to study whether pharmacogenetics explains some variability response fentanyl, several genes related fentanyl receptors, transporters and metabolic enzymes have been analysed. Thirty-five healthy volunteers (19 men 16 women) receiving a single 300 μg oral dose were genotyped for 9 polymorphisms cytochrome P450 (CYP) (CYP3A4 CYP3A5), ATP-binding cassette subfamily B member 1 (ABCB1),...
A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed validated in human plasma for the simultaneous determination of aripiprazole (ARI) its metabolite dehydro-aripiprazole (DARI); olanzapine (OLA), risperidone (RIS), paliperidone (PAL), quetiapine (QUE), clozapine (CLO) caffeine (CAF). CAF is included to because it can have an influence on drug metabolism due competitive inhibition. The above mentioned compounds their isotope-labeled internal standards...
Background: Agomelatine is an agonist of the melatoninergic receptors used for treatment depression. Our aim was to evaluate effect genetic polymorphisms in metabolising enzymes and P-glycoprotein transporter on agomelatine pharmacokinetics pharmacodynamics. Methods: Twenty-eight healthy volunteers receiving a single 25 mg oral dose agomelatine, were genotyped nine cytochrome P450 ( CYP1A2, CYP2C9 CYP2C19) adenosine triphosphate-binding cassette subfamily B member 1 ABCB1), by real-time...
Background/Objectives: Pregabalin is a useful therapeutic option for patients with anxiety or neuropathic pain. Genetic variants in certain genes encoding transporters related to absorption and distribution could have an impact on the efficacy safety of drug. Furthermore, extreme phenotypes metabolic enzymes alter pregabalin-limited metabolism. Methods: In this study, we included 24 healthy volunteers participating bioequivalence clinical trial administered pregabalin 300 mg orally; 23...
Lurbinectedin is an oncogenic transcription inhibitor indicated for the treatment of small cell lung cancer (SCLC), which has also shown activity against other malignancies. In this work, two independent cohorts 180 (discovery cohort) and 719 (validation patients receiving lurbinectedin in Phases I, II, or III clinical trials were enrolled. Using a population pharmacokinetic (popPK) model discovery cohort, with extremely high (n = 10, cohort 1) low 2) etaCL values (i.e., variable used as...
A novel haplotype composed of two non-coding variants, CYP2C18 NM_000772.3:c.*31T (rs2860840) and NM_000772.2:c.819+2182G (rs11188059), referred to as "CYP2C:TG," was recently associated with ultrarapid metabolism various CYP2C19 substrates. As the underlying mechanism clinical relevance this effect remain uncertain, we analyzed existing in vivo vitro data determine magnitude CYP2C:TG effect. We assessed variability pharmacokinetics substrates, including citalopram, sertraline, voriconazole,...
Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many patients discontinue therapy due to adverse reactions, especially myopathy. The Dutch Pharmacogenetics Working Group (DPWG) recommends an alternative agent atorvastatin simvastatin or a dose adjustment depending on other risk factors statin-induced myopathy SLCO1B1 rs4149056 CC TC carriers. In contrast, Clinical...
Thiopurine drugs are purine nucleoside analogues used for treatment of different immune-related conditions. To date, studies highlighted the importance thiopurine methyltransferase (TPMT) genotyping in patients who initiate with thiopurines to make an adequate dose adjustment. We aimed investigate influence TPMT phenotype, concomitant treatments, and demographic characteristics on incidence adverse reactions (ADRs) start azathioprine (AZA). This was observational retrospective study. The...
Diazepam is a benzodiazepine (BZD) used worldwide for variety of conditions. Long-term use diazepam increases the risk developing tolerance and dependence occurrence adverse drug reactions (ADRs). CYP3A4 CYP2C19 mainly metabolize are therefore primary pharmacogenetic candidate biomarkers. In this work, we aimed to explore impact phenotypes 99 additional variants in other 31 pharmacogenes (including CYP, UGT, NAT2 CES enzymes, ABC SLC transporters) on pharmacokinetic variability safety. 30...
Amlodipine is an antihypertensive drug with unknown pharmacogenetic biomarkers. This research a candidate gene study that looked for associations between amlodipine pharmacokinetics and safety pharmacogenes. Pharmacokinetic data were taken from 160 volunteers eight bioequivalence trials. In the exploratory step, 70 genotyped 44 polymorphisms in different CYP2D6 poor metabolizers (PMs) showed higher half-life (t1/2) (univariate p-value (puv) = 0.039, multivariate (pmv) 0.013, β -5.31, R2...
Aripiprazole is an atypical antipsychotic drug that metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, which mainly form its active metabolite dehydro-aripiprazole. Because of the genetic polymorphism CYP2D6, plasma concentrations are highly variable between different phenotypes. In this study, phenotype-related physiologically based pharmacokinetic models were developed evaluated to suggest phenotype-guided dose adjustments. Physiologically for single (oral orodispersible formulation),...
For patients with type 2 diabetes, metformin is the most often recommended drug. However, there are substantial individual differences in pharmacological response to metformin. To investigate effect of transporter polymorphisms on pharmacokinetics an environment free confounding variables, we conducted our study healthy participants. This first investigation consider demographic characteristics alongside all transporters involved distribution. Pharmacokinetic parameters were found be...
Aims Pupillography is a noninvasive and cost‐effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 ( CYP ), dopamine receptor DRD2 , DRD3 serotonin HTR2A HTR2C ) ATP‐binding cassette subfamily B ABCB1 genes, among others, were previously associated with the pharmacokinetics pharmacodynamics of antipsychotic drugs. Our aim was evaluate effects aripiprazole olanzapine on pupillary light reflex related pharmacogenetics. Methods Twenty‐four healthy...
Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the side effects produced by aripiprazole more benign. The aim of study was to evaluate if alter prolactin levels, lipid glucose metabolism hepatic, haematological, thyroid renal function. Twenty-four healthy volunteers received a daily oral dose 10 mg 5 tablets for days in crossover randomised clinical trial were genotyped 51 polymorphisms 18 genes qPCR. Drug plasma concentrations...