A5051031143- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Diet and metabolism studies
- Digestive system and related health
- Biosimilars and Bioanalytical Methods
- Pharmacological Effects and Toxicity Studies
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- Advanced Sensor Technologies Research
- Diet, Metabolism, and Disease
- Clinical Laboratory Practices and Quality Control
- Gastrointestinal motility and disorders
- Bacterial Identification and Susceptibility Testing
- Drug Transport and Resistance Mechanisms
- Child Nutrition and Feeding Issues
- Pesticide Residue Analysis and Safety
- Pharmacovigilance and Adverse Drug Reactions
Hospital Universitario de La Princesa
2022-2025
Universidad Autónoma de Madrid
2022-2025
Clinica Universidad de Navarra
2020-2023
Background/Objectives: Pregabalin is a useful therapeutic option for patients with anxiety or neuropathic pain. Genetic variants in certain genes encoding transporters related to absorption and distribution could have an impact on the efficacy safety of drug. Furthermore, extreme phenotypes metabolic enzymes alter pregabalin-limited metabolism. Methods: In this study, we included 24 healthy volunteers participating bioequivalence clinical trial administered pregabalin 300 mg orally; 23...
Diazepam is a benzodiazepine (BZD) used worldwide for variety of conditions. Long-term use diazepam increases the risk developing tolerance and dependence occurrence adverse drug reactions (ADRs). CYP3A4 CYP2C19 mainly metabolize are therefore primary pharmacogenetic candidate biomarkers. In this work, we aimed to explore impact phenotypes 99 additional variants in other 31 pharmacogenes (including CYP, UGT, NAT2 CES enzymes, ABC SLC transporters) on pharmacokinetic variability safety. 30...
Amlodipine is an antihypertensive drug with unknown pharmacogenetic biomarkers. This research a candidate gene study that looked for associations between amlodipine pharmacokinetics and safety pharmacogenes. Pharmacokinetic data were taken from 160 volunteers eight bioequivalence trials. In the exploratory step, 70 genotyped 44 polymorphisms in different CYP2D6 poor metabolizers (PMs) showed higher half-life (t1/2) (univariate p-value (puv) = 0.039, multivariate (pmv) 0.013, β -5.31, R2...
Venlafaxine pharmacokinetic variability and pharmacotherapy outcomes are well known to be related CYP2D6 pharmacogenetic phenotype. In contrast, scarce information is available nowadays concerning desvenlafaxine, its active metabolite first marketed in 2012. The aim of this study was evaluate the impact 29 alleles 12 candidate genes (e.g., CYP enzymes like CYP2D6, CYP3A4, or CYP2C19; ABC transporters ABCB1; SLCO1B1; UGT UGT1A1) on desvenlafaxine tolerability. Pharmacokinetic parameters...
Rasagiline is a selective and irreversible inhibitor of monoamine oxidase type B with neuroprotective effect, indicated for the management Parkinson's disease. The aim this work was to evaluate impact seven CYP1A2 alleles 120 additional variants located in other CYP enzymes (e.g., CYP2C19), UGT UGT1A1) or NAT2), transporters SLCO1B1) on pharmacokinetic variability safety rasagiline. A total 118 healthy volunteers enrolled four bioequivalence clinical trials consented participate...
Abstract Objectives Retrospective studies frequently assume analytes long-term stability at ultra-low temperatures. However, these storage conditions, common among biobanks and research, may increase the preanalytical variability, adding a potential uncertainty to measurements. This study is aimed evaluate of different <−70 °C assess its impact on reference change value formula. Methods Twenty-one commonly measured in clinical laboratories were quantified 60 serum samples. Samples...
Abstract Objectives Lactose malabsorption is generally assessed by hydrogen breath testing (HBT). However, this test not recommended in patients with high baseline concentrations (H 2 B). In addition, the current situation created COVID-19 pandemic, due to potential infectiveness of samples. The objective assess concordance between HBT and lactose tolerance (LTT) depending on H B concentrations. Methods A total 430 (40 years, Q1–Q3 = 28–54 years; 66.7% women) suspected were included study....
Abstract Breath tests used to evaluate carbohydrates malabsorption require baseline H 2 and CH 4 levels as low possible. Test cancellation is recommended when exceeding certain cut-offs (H ≥ 20 ppm 10 ppm). Although following preparation protocols, many patients have above those cut-offs. We investigated if light walking can reduce levels. retrospectively analyzed from 1552 breath tests. Baseline (B1), especially in , were lower obtained at later hours of the day. In with cut-off,...
Causality algorithms help establish relationships between drug use and adverse event (AE) occurrence. High exposure leads to a higher likelihood of an AE being classified as reaction (ADR). However, there is knowledge gap regarding what concentrations are predictive ADRs, this has not been systematically studied. In work, the Spanish Pharmacovigilance System (SEFV) algorithm was used define relationship occurrence administration in 178 healthy volunteers participating five desvenlafaxine...
Resumen Objetivos La malabsorción de lactosa se estudia habitualmente mediante el test hidrógeno espirado (HBT), aunque su realización no es recomendable cuando la concentración basal (H 2 B) elevada. Además, situación actual en relación con SARS-CoV-2 puede hacer desaconsejable manejo muestras aliento. Objetivo: Evaluar concordancia del HBT y tolerancia a (TTL) función H B. Métodos Se estudiaron 430 pacientes (40 años, Q1–Q3 = 28–54 años; 66,7% mujeres) sospecha lactosa. recogieron...