A5044852576- Clinical Laboratory Practices and Quality Control
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Hemodynamic Monitoring and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Renal function and acid-base balance
- Biosimilars and Bioanalytical Methods
- Health and Medical Research Impacts
- Parathyroid Disorders and Treatments
- Pesticide Residue Analysis and Safety
- Quality and Safety in Healthcare
- Sepsis Diagnosis and Treatment
- Diabetes Management and Research
- Muscle metabolism and nutrition
- Molecular Biology Techniques and Applications
- Neonatal Health and Biochemistry
- Iron Metabolism and Disorders
- Diabetes and associated disorders
- Bone health and osteoporosis research
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Electrolyte and hormonal disorders
- Bacterial Identification and Susceptibility Testing
- Antioxidant Activity and Oxidative Stress
Hospital Universitario La Paz
2016-2025
Hospital La Paz Institute for Health Research
2024-2025
Walter de Gruyter (Germany)
2023-2024
Baidu (China)
2023-2024
Naver (South Korea)
2023-2024
Clinica Universidad de Navarra
2023-2024
University of Cuenca
2024
Spanish Society of Family and Community Medicine
2016-2023
Galveston College
2023
Société Française de Cardiologie
2023
Abstract This paper, prepared by the EFLM Task and Finish Group on Allocation of laboratory tests to different models for performance specifications (TFG-DM), is dealing with criteria allocating measurands analytical (APS) recognized in 1st Strategic Conference Consensus Statement. Model 1, based effect APS clinical outcome, model choice that have a central role decision-making specific disease or situation where cut-off/decision limits are established either diagnosing, screening...
Data on biological variation are used for many purposes in laboratory medicine but concern exists over the validity of data reported some studies. A critical appraisal checklist has been produced by a working group established European Federation Clinical Chemistry and Laboratory Medicine (EFLM) to enable standardised assessment existing future publications data. The identifies key elements be studies safe accurate effective transport sets across healthcare systems. is mapped domains minimum...
Abstract Background: Biological variation (BV) data have many fundamental applications in laboratory medicine. At the 1st Strategic Conference of European Federation Clinical Chemistry and Laboratory Medicine (EFLM) reliability limitations current BV were discussed. The EFLM Working Group on Variation is working to increase quality by developing a project establish biobank samples from healthy subjects be used produce high data. Methods: involved six laboratories (Milan, Italy; Bergen,...
Abstract BACKGROUND The European Federation of Clinical Chemistry and Laboratory Medicine Biological Variation Study (EuBIVAS) has been established to deliver rigorously determined data describing biological variation (BV) clinically important measurands. Here, EuBIVAS-based BV estimates serum electrolytes, lipids, urea, uric acid, total protein, bilirubin, direct glucose, as well their associated analytical performance specifications (APSs), are presented. METHOD Samples were drawn from 91...
Blood biomarkers have proven useful in Alzheimer's disease (AD) research. However, little is known about their biological variation (BV), which improves the interpretation of individual-level data.
Analytical performance specifications (APS) are typically established through one of three models: (i) outcome studies, (ii) biological variation (BV), or (iii) state-of-the-art. Presently, The APS can, for most measurands that have a stable concentration, be based on BV. BV APS, defined imprecision, bias, total allowable error and measurement uncertainty, applied to many different processes in the laboratory. When calculating it is important consider formulae, what setting they if suitable...
Numerical data on the components of biological variation (BV) have many uses in laboratory medicine, including setting analytical quality specifications, generation reference change values and assessment utility conventional values.Generation a series up-to-date comprehensive database BV was initiated 1997, integrating more relevant information found publications concerning BV. A scoring system designed to evaluate robustness included. The has been updated every 2 years, made available...
Abstract BACKGROUND The European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Biological Variation Study (EuBIVAS) has been established to deliver rigorously determined biological variation (BV) indices. EuBIVAS BV for serum creatinine using the enzymatic alkaline picrate measurement methods. METHOD In total, 91 healthy individuals (38 males, 53 females; age range, 21–69 years) were bled 10 consecutive weeks at 6 laboratories. An equivalent protocol was followed each...
Among medical specialties, laboratory medicine is the largest producer of structured data and must play a crucial role for efficient safe implementation big artificial intelligence in healthcare. The area personalized therapies precision has now arrived, with huge sets not only used experimental research approaches, but also "
We sought to develop estimates of biological variation (BV) for 9 enzymes in blood serum as part the European Biological Variation Study.Ninety-one healthy study participants (38 male and 53 female, 21-69 years old) were phlebotomized each 10 consecutive weeks at 6 laboratories. The same preanalytical sample-handling protocol was followed center before transport San Raffaele Hospital, Milan, Italy, analysis. Sera stored -80 °C analysis duplicate within a single run on an ADVIA 2400 Clinical...
The complete blood count (CBC) is used to evaluate health status in the contexts of various clinical situations such as anemia, infection, inflammation, trauma, malignancies, etc. To ensure safe application CBC, reliable biological variation (BV) data are required. study aim was define BVs CBC parameters employing a strict protocol.Blood samples, drawn from 30 healthy subjects (17 females, 13 males) once weekly for 10 weeks, were analyzed using Sysmex XN 3000 instrument. assessed normality,...
The European Biological Variation Study (EuBIVAS) was established to deliver rigorously determined data for biological variation (BV). Here, EuBIVAS-based BV estimates are provided α1-acid glycoprotein, α1-antitrypsin, albumin, β2-microglobulin, ceruloplasmin, complement component 3, 4, C-reactive protein (CRP), cystatin C, haptoglobin, IgA, IgG, IgM, soluble transferrin receptor (sTfR), and (Trf), together with their associated analytical performance specifications (APSs) reference change...
Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and monitoring treatment patients with these diseases. The knowledge biological variation (BV) is important to define analytical performance specifications (APS) reference change values (RCV). aim this study was deliver BV estimates stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (FT3), thyroglobulin (TG), calcitonin (CT).Analyses were performed on serum samples obtained from European Biological...
The aims of this study are: 1) to use the data included in biological variation (BV) database address usability BV estimates; and 2) different examples from authors' laboratories illustrate usefulness laboratory medicine. is an essential tool for management. Examples application derived are given paper, such as analytical performance specifications that have been various quality control software designed optimize operative rules; also they incorporated acceptability limits external assurance...
Abstract Stability of a measurand in specimen is function the property variation over time specific storage conditions, which can be expressed as stability equation, and usually simplified to limits (SLs). studies show differences or even inconsistent results due lack standardized experimental designs heterogeneity chosen specifications. Although guidelines for validation sample collection tubes have been published recently, evaluation not addressed. This document provides an easy guideline...
Abstract Background Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation biological variation (BV) cTn. knowledge BV is important to define analytical performance specifications (APS) reference change values (RCVs). aim this study was estimate within- between-subject weekly (CV I , CV G ) cTnI applying two assays, using European...