A5020456692- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- CNS Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Optic Conditions
- Polyomavirus and related diseases
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Ultrasound Imaging and Elastography
- Ocular Diseases and Behçet’s Syndrome
- Pain Mechanisms and Treatments
- Optical Coherence Tomography Applications
- Neurological Complications and Syndromes
- Glaucoma and retinal disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Genetics and Neurodevelopmental Disorders
Hospital Universitari Sant Joan de Reus
2022-2024
Institut d'Investigació Sanitària Pere Virgili
2022-2024
Universitat de Barcelona
2013-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013-2022
Hospital Clínic de Barcelona
2011-2022
Hospital General de Granollers
2020
Instituto Nacional de Neurología y Neurocirugía
2019
University of Pennsylvania
2019
Institució Catalana de Recerca i Estudis Avançats
2019
Althaia
2017
Background:Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is important because it can be the first manifestation a neurodegenerative disease, may lead to serious injury, and well-treatable disorder. We evaluated electromyographic (EMG) activity in Sleep Innsbruck Barcelona (SINBAR) montage (mentalis, flexor digitorum superficialis, extensor brevis) other muscles obtain normative values for correct RBD clinical practice.
Significance Application of antigen-specific immune tolerance in autoimmune disease is a long-sought goal. We studied diseases with abundant information on the target: multiple sclerosis (MS), various myelin antigens are known targets T cells and antibodies, whereas neuromyelitis optica (NMO), aquaporin-4 channel attacked by antibodies. tested whether engineered dendritic might induce tolerogenic response these two conditions. In this in-human clinical study, individual regulatory cells,...
Objective Uncontrolled studies of mesenchymal stem cells (MSCs) in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind, placebo-controlled, crossover phase II study we investigated their safety and efficacy relapsing-remitting patients. Efficacy was evaluated terms cumulative number gadolinium-enhancing lesions (GEL) on magnetic resonance imaging (MRI) at 6 months the end study. Methods Patients unresponsive to conventional therapy, defined by least 1...
To (1) determine the value of recently proposed criteria neuromyelitis optica (NMO) spectrum disorder (NMOSD) that unify patients with NMO and those limited forms (NMO/LF) aquaporin-4 immunoglobulin G (AQP4-IgG) antibodies; (2) investigate clinical significance serologic status in NMO.This was a retrospective, multicenter study 181 fulfilling 2006 (n = 127) or NMO/LF AQP4-IgG 54). myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies were tested using cell-based assays.Patients mainly...
Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed describe response different strategies adult patients with relapsing MOG-Ab-associated disease.This a retrospective study conducted France and Spain including 125 MOG-Ab aged ≥ 18 years. First, we performed survival analysis investigate relapse risk between treated non-treated patients, performing propensity...
Attention and executive deficits are disabling symptoms in multiple sclerosis (MS) that have been related to disconnection mechanisms. We aimed investigate changes structural connectivity MS their association with attention performance applying an improved framework combines high order probabilistic tractography anatomical exclusion criteria postprocessing. compared graph theory metrics of networks fractional anisotropy (FA) white matter (WM) connections or edges between 72 subjects 38...
Background: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with implementation of new 2015 criteria. Objectives: To estimate incidence prevalence NMOSD in Catalonia (Spain), using both 2006 Methods: In this clinic-based retrospective study, patients diagnosed between were identified multiple sources, including direct contact to all Catalan hospitals, identification cases through Health Surveillance...
Background: In a minority of patients with neuromyelitis optica spectrum disorder (NMOSD) and aquaporin-4 antibodies (AQP4-IgG), the disease has paraneoplastic origin. It is unknown whether these have distinctive clinical features. Objective: To report features series NMOSD AQP4-IgG to review previously reported cases. Methods: Retrospective analysis records 156 AQP4-IgG. Paraneoplastic were defined as those cancer identified within 2 years diagnosis NMOSD. Results: Five (3.2%) had NMOSD, 12...
Analizar el perfil clínico, los tipos de tumor asociado y la respuesta al tratamiento síndromes neurológicos paraneoplásicos asociados a anticuerpos contra proteínas Ma. Estudio retrospectivo pacientes con Ma identificados en un laboratorio referencia neuroinmunología. Se diagnosticó 32 pacientes, 20 reactividad frente Ma2 aislada (anticuerpos anti-Ma2), 11 Ma1 anti-Ma) uno anti-Ma1). La presentación clínica más frecuente fue cuadro neurológico que forma o combinación afectó sistema límbico,...
To describe the clinical features of late-onset (≥50 years) neuromyelitis optica spectrum disorder (LO-NMOSD), to compare outcome with that early-onset (EO-NMOSD), and identify predictors disability.A retrospective, multicenter study 238 patients NMOSD identified by 2015 criteria. Clinical immunologic LO-NMOSD were compared those EO-NMOSD. All evaluated for aquaporin-4 (AQP4-IgG) myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies.Sixty-nine (29%) had LO-NMOSD. Demographic features,...
Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes with antibodies against Ma proteins. A retrospective study patients proteins identified in a neuroimmunology laboratory reference. Of 32 identified, 20 showed reactivity Ma2 only (anti-Ma2 antibodies), 11 Ma1 (anti-Ma 1 (anti-Ma1 antibodies). The most common presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem frequently appearing as...
Objectives: Our aim was to investigate the impact of gray matter (GM) integrity on cognitive performance in multiple sclerosis (MS), and its relationship with white (WM) presence lesions. Methods: Sixty-seven patients MS 26 healthy controls underwent voxel-based analysis diffusion tensor images (DTI) GM tract-based spatial statistics (TBSS) from WM identify regional correlations between functions integrity. Lesion probability mapping (LPM) generated for correlation cognition. Multiple linear...
Before using brain volume loss (BVL) as a marker of therapeutic response in multiple sclerosis (MS), certain biological and methodological issues must be clarified.To assess the dynamics BVL MS progresses to evaluate repeatability exchangeability estimates with Jacobian Integration (JI) Functional Magnetic Resonance Imaging Brain (FMRIB) Software Library (FSL) (specifically, Structural Image Evaluation, Using Normalisation, Atrophy-Cross-Sectional [SIENA-X] tool or FMRIB's Integrated...
To assess the feasibility of a structured telephone interview examining long-term cognitive and functional status in anti-leucine-rich, glioma-inactivated 1 (LGI1) encephalitis.
Abstract Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) used and licensed as a symptomatic treatment ameliorate ambulatory sclerosis. The presumed mode of action via blockade axonal voltage gated potassium channels, thereby enhancing conduction demyelinated axons. In this study, we provide evidence that addition those effects, 4-AP can prevent loss the CNS. Using vivo optical coherence tomography imaging, visual function testing...
The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications microstructure, and we quantified volume loss GM cohort patients with MS classified into three groups according disease duration. Additionally, investigated the relationship between changes severity. studied 54 healthy controls 247 regarding duration: MS1 (less than 5 years, n =...
Since a decline in the ovary function might impact reproductive potential women with multiple sclerosis (MS), we investigated pituitary-ovary axis and ovarian reserve, including anti-Müllerian hormone (AMH) levels ultrasound imaging of ovaries, 25 relapsing–remitting MS patients age-matched healthy controls. Mean pituitary-gonadal hormones age-adjusted parameters reserve markers were not significantly different between both groups. Patients higher disease activity (annualized relapse rate...
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory central nervous system disease that preferentially affects the optic nerve and spinal cord [Wingerchuk et al. 2015]. Up to 70% of patients with NMOSD have antibodies aquaporin-4 (AQP4-IgG). AQP4 expressed in astrocytes Muller cells eye. A subgroup AQP4-IgG-seronegative has myelin oligodendrocyte glycoprotein (MOG-IgG), neuritis (ON) relapses are also frequent these [Hoftberger 2015]. We hypothesize retinal injury may be...
Visual impairment significantly alters the quality of life people with Multiple Sclerosis (MS). The objective this study was to identify predictors (independent variables) visual outcomes, and define their relationship neurological disability retinal atrophy when assessed by optical coherence tomography (OCT). We performed a cross-sectional analysis 119 consecutive patients MS, assessing vision using high contrast acuity (LogMar), 2.5% 1.25% low (Sloan charts), color (Hardy-Rand-Rittler...
Neuroprotective and remyelinating therapies are required for multiple sclerosis (MS), acute optic neuritis (AON) is a potential condition to evaluate such treatments.To comprehensively assess key biological methodological aspects of AON trials testing neuroprotection remyelination in MS.The AON-VisualPath prospective cohort study was conducted from February 2011 November 2018 at the Hospital Clinic University Barcelona, Spain. Consecutive patients with were prospectively enrolled followed up...