A5001928149- Multiple Sclerosis Research Studies
- Tryptophan and brain disorders
- HIV Research and Treatment
- MicroRNA in disease regulation
- Genetic Neurodegenerative Diseases
- Spaceflight effects on biology
- Bipolar Disorder and Treatment
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Intimate Partner and Family Violence
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- Optical Coherence Tomography Applications
- Autoimmune and Inflammatory Disorders Research
- Growth Hormone and Insulin-like Growth Factors
- Cell Image Analysis Techniques
- Bullying, Victimization, and Aggression
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Nanocluster Synthesis and Applications
- Functional Brain Connectivity Studies
- Electrolyte and hormonal disorders
- Vestibular and auditory disorders
- Diet and metabolism studies
- Peripheral Neuropathies and Disorders
Servicio Gallego de Salud
2023-2025
Instituto de Investigación Sanitaria de Santiago
2022-2024
Complejo Hospitalario Universitario de Santiago
2018-2023
Schizophrenia (SZ) is a serious mental disorder that typically treated with antipsychotic medication. Treatment-resistant schizophrenia (TRS) the condition where symptoms remain after pharmacological intervention, resulting in long-lasting functional and social impairments. As identification treatment of TRS patient requires previous failed treatments, early mechanisms detection are needed order to quicken access effective therapy, as well improve adherence. In this study, we aim find...
Introduction: Stroke has an enormous impact on society, both socially and economically. It is the most common cause of admission prolonged stay in Neurology ward. Methods: We performed a cost-effectiveness analysis stroke treatment Complejo Hospitalario de Santiago Compostela, where patients are treated unit. Firstly, costs unit was carried out, which had not been done before. The were compared with those that would be incurred if disease without unit, verifying existence such implies...
Multiple sclerosis (MS) is a multifaceted neurological condition characterized by challenges in timely diagnosis and personalized patient management. The application of Artificial Intelligence (AI) to MS holds promises for early detection, accurate diagnosis, predictive modeling. objectives this study are: 1) propose new trajectory descriptors that could be employed Machine Learning (ML) regressors classifiers predict evolution; 2) explore the contribution ML models discerning using only...
Background: Multiple sclerosis (MS) treatment has radically improved over the last years; however, MS symptom management is still challenging. The novel Spasticity-Plus syndrome was conceptualized to frame several spasticity-related symptoms that can be addressed together with broad-spectrum medication, such as certain cannabinoid-based drugs. aim of this project gain insight into Spanish neurologists' clinical experience on spasticity and associated symptoms, assess acknowledgment...
Early identification of the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) can be challenging for clinicians, as diagnostic criteria SPMS are primarily based on physical disability and a holistic interpretation.To establish consensus patient monitoring identify promptly disease progression most useful clinical paraclinical variables early in MS.A RAND/UCLA Appropriateness Method was used level agreement among panel 15 medical experts MS....
The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker not evaluated depression. To do this, we measured plasma IGF-2 other members of the IGF family such Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 IGFBP-7) depressed group patients (n = 51) healthy control 48). In some these 15), proteins after period (19 ± 6 days) treatment with antidepressants. Hamilton...
Introduction: Bipolar disorder (BD) is a recurrent and disabling psychiatric related to low-grade peripheral inflammation altered levels of the members insulin-like growth factor (IGF) family. The aim this study was evaluate plasma IGF-2, factor-binding protein 1 (IGFBP-1), IGFBP-3, IGFBP-5, IGFBP-7, inflammatory markers such as tumor necrosis α (TNF-α), monocyte chemoattractant (MCP-1), macrophage 1β (MIP-1β). Methods: We used Young Mania Rating Scale (YMRS) determine severity...
Introduction Peripheral neurofilament light chain (NfL) reflect neuronal and axonal damage. Most studies have been focused on NfL cerebrospinal fluid measures since peripheral levels were difficult to detect. However, with recent advent of single molecule array (SIMOA) technology, is now detectable peripherally at small concentrations (pg/ml). In neurodegenerative disorders, found significantly elevated compared against psychiatric disorders. there still controversy whether might be altered...
Peer Victimization (PV) or being bullied in childhood/adolescence has been associated with several negative outcomes mental health conditions beyond the time of its occurrence. However, possible association personality disorders slightly explored. In present study we have compared frequency DSM IV among adult patients (N = 28) without 418) a reported history PV. For this purpose, axis II was evaluated Self-Report Checklist for Preliminary Items Major Categories, whereas self-esteem and...
The EMCOVID project conducted a multi-centre cohort study to investigate the impact of COVID-19 on patients with Multiple Sclerosis (pwMS) receiving disease-modifying therapies (DMTs). aimed evaluate seroprevalence and persistence SARS-CoV-2 antibodies in MS enrolled database. DMTs were used manage by reducing relapses, lesion accumulation, disability progression. However, concerns arose regarding susceptibility pwMS due potential interactions between immune system, as well immunomodulatory...