A5006123683- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Obesity, Physical Activity, Diet
- Neuroinflammation and Neurodegeneration Mechanisms
- Physical Activity and Health
- Toxic Organic Pollutants Impact
- Neurobiology of Language and Bilingualism
- Food Quality and Safety Studies
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Infant Development and Preterm Care
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Amino Acid Enzymes and Metabolism
- Sports Performance and Training
- Agriculture, Soil, Plant Science
- Protein purification and stability
- Nutrition, Health and Food Behavior
- Frailty in Older Adults
- bioluminescence and chemiluminescence research
- Functional Brain Connectivity Studies
- Nitric Oxide and Endothelin Effects
Doshisha University
2022-2024
Ehime University
2015-2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Hamamatsu University
2019
University of Yamanashi
2018
Mie University
2013-2017
Akita Prefectural University
2014-2016
National Institutes for Quantum Science and Technology
2012
Imaging Center
2012
Despite many studies about the association between caregiver burden and behavioral psychological symptoms of dementia (BPSD), there have been no population-based to evaluate associated with each BPSD.To individual BPSD in elderly people living community.The subjects were 67 participants their caregivers (diagnosed third Nakayama study): 51 Alzheimer's disease, 5 vascular 11 other. The Neuropsychiatric Inventory (NPI) NPI Caregiver Distress Scale (NPI-D) used assess subjects' related...
Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis patients increase caregiver distress. The aims this study were to clarify differences trajectories 12 kinds BPSDs by disease severity in four major dementias develop charts showing frequency, severity, associated distress (ACD) using data a Japan multicenter (J-BIRD).We gathered Neuropsychiatric Inventory (NPI) with Alzheimer's (AD; n = 1091), Lewy bodies (DLB; 249), vascular (VaD; 156), frontotemporal...
<h3>Objective</h3> Neuropsychiatric symptoms affect many patients with Alzheimer9s disease (AD). (<sup>11</sup>C)Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled the in vivo visualisation of brain amyloid-β (Aβ) deposition. This study exploratively investigated correlation between Aβ deposition measured by (<sup>11</sup>C)PIB PET and neuropsychiatric AD. <h3>Methods</h3> Participants were 28 (15 women, 13 men) PIB-positive Clinical assessments included Mini-Mental...
Abstract Background The burden of dementia is growing rapidly and has become a medical social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors etiology dementia. We aimed perform large-scale study elucidate environmental genetic for dementia, as well their interaction. Methods Japan Studies Collaboration Aging Dementia (JPSC-AD) multisite, population-based prospective which was designed enroll approximately 10,000...
<h3>BACKGROUND AND PURPOSE:</h3> Previous neuropathologic studies in chronic hydrocephalus have suggested the presence of white matter damage, presumably from mechanical pressure due to ventricular enlargement and metabolic derangement. This study aimed investigate diffusional properties CST patients with iNPH by using DTI determine whether this method could be used as a new diagnostic tool differentiate those AD PDD control subjects. <h3>MATERIALS METHODS:</h3> We enrolled 18 iNPH, 11 AD,...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
Abstract Background When comparing with early‐onset Alzheimer's disease (EO‐AD) and late‐onset (LO‐AD), some symptomatological differences in clinical features can be seen between them. Rapid progression, more severe language problems or visuospatial dysfunction occur often EO‐AD patients. However, there have been very few reports about the behavioral psychological symptoms these two groups. Aim The aim of this study was to demonstrate LO‐AD Method Three hundred seven consecutive outpatients...
It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap both Alzheimer's disease Parkinson's disease. The α-synuclein protein a major component of bodies, accumulation aggregates causes synaptic dysfunction in DLB. Epigenetic changes at the synuclein alpha ( SNCA ) gene may be involved DLB pathogenesis.We examined DNA methylation rates 10 CpG sites located intron 1 mRNA expression peripheral leukocytes compare patients (n = 20;...
The authors explored the neural substrate of visual hallucinations in dementia with Lewy bodies (DLB) by investigating changes regional cerebral blood flow (rCBF) and psychiatric symptoms, before after cholinesterase inhibitor treatment. Twenty subjects DLB were treated donepezil for a 12-week period. Hallucinations attenuated while receiving therapy, whereas occipital rCBF focally increased, suggesting that functional association cortex deficits may cause patients DLB.
To investigate the frequency, rate of causes dementia, and clinical characteristics early-onset dementia in consecutive patients a memory clinic.A total 668 demented were involved this study. We examined distribution patients' diagnosis, differences sex, education, severity cognitive function at first visit, duration from onset to consultation. also changes proportion subjects during research period.There 185 patients, 28% all patients. No significant observed between late-onset groups...
Background: Eating problems occur frequently in patients with dementia, and almost half of all Parkinson's disease have such problems. It has therefore been assumed that eating are also common dementia Lewy bodies (DLB). However, few systematic studies investigated DLB patients. The aim this study was to clarify the frequency characteristics DLB.Methods: We examined 29 consecutive 33 Alzheimer's (AD) terms age, sex, education, Mini-mental State Examination, clinical rating (CDR),...
Background Sleep disturbances in Alzheimer disease (AD) may affect behavioral and psychological symptoms of dementia (BPSD). Our aim was to elucidate the associations between sleep other BPSD at different stages AD. Methods This investigation part a multicenter‐retrospective study Japan (J‐BIRD). Eligible for final analyses were 684 AD patients. Global severity estimated using Clinical Dementia Rating (CDR) scale. assessed Neuropsychiatric Inventory (NPI). We analyzed relationships according...
Despite continuing research into Alzheimer's disease (AD), its pathological mechanisms and modulating factors remain unknown. Several genes influence AD pathogenesis by affecting inflammatory pathways. Myocyte-enhancer factor 2C (MEF2C) is one such candidate gene for AD.We examined MEF2C mRNA expression levels methylation rates of CpG on promoter region in peripheral leukocytes from Japanese patients compared with age- sex-matched control subjects.In leukocytes, subjects were significantly...
Microglial dysfunction and inflammation have recently been shown to be related the development of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase (INPP5D) functions broadly as a negative regulator immune signaling, its locus was associated with AD in large- scale genome-wide association study. Thus, we examined INPP5D mRNA expression methylation rates CpG sites upstream region exon 1 peripheral leukocytes 50 age- sex-matched control subjects. subjects significantly higher than...
Abstract Alzheimer's disease (AD) is a progressive disease, and the number of AD patients increasing every year as population ages. One pathophysiological mechanisms thought to be effect metabolomic abnormalities. There have been several studies abnormalities AD, new biomarkers are being investigated. Metabolomic attracting attention, aim this study was identify associated with mild cognitive impairment (MCI). Of 927 participants in Nakayama Study conducted Iyo City, Ehime Prefecture, 106...
Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine (NET). Recent studies suggest that and inhibitors block both 5-HTT NET have better tolerability than tricyclic antidepressants may higher compared to selective inhibitors. Previous positron emission tomography (PET) reported >80% occupancy with clinical doses antidepressants, but there has been no report in patients treated antidepressants. In the...
Despite the continuing debate about amyloid hypothesis in Alzheimer's disease (AD), precise pathogenesis is still unclear. Mixed pathology common and multiple different protein aggregates are seen human postmortem brains. Aggregates consisting of alpha-synuclein encoded by Synuclein Alpha gene (SCNA) both dementia with Lewy bodies AD. We examined SNCA mRNA expression methylation rates CpG island at intron 1 peripheral leukocytes 50 AD age- sex-matched control subjects to verify whether...
TREM2 and TYROBP are causal genes for Nasu–Hakola disease (NHD), a rare autosomal recessive characterized by bone lesions early-onset progressive dementia. forms receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages dendritic cells, functional polymorphism is reported to be associated neurodegenerative disorders such as Alzheimer's (AD). The objective this study was reveal involvement pathophysiology AD schizophrenia. Methods: We...
Background/Objective: The aim of this study was to examine the blood gene expression and methylation ATP-binding cassette sub-family A member 7 (ABCA7) as a biological marker AD. Methods: AD subjects ( n = 50; 11 males, 77.7±6.05 years old) age- sex-matched healthy controls 50) were recruited. single nucleotide polymorphism in ABCA7 (rs3764650), rates CpG sites promoter region, mRNA levels peripheral examined. Results: distribution rs3764650 not different from that controls. Although...
TOMM40 is located on chromosome 19, in linkage disequilibrium with apolipoprotein E (APOE), andis reported several genome-wide association studies to be associated Alzheimer's disease (AD).Assess APOE and TOM40 mitochondrial genes as blood biomarkers for AD.We examined TOMM40, PTEN-induced putative kinase 1 (PINK1), Parkin RBR E3 ubiquitin protein ligase (PARK2), mRNA expression relation the methylation rates of CpG sites upstream region TOMM40exon peripheral leukocytes TOMM40523 polyT...
Background: Triggering receptor expressed on myeloid cells 2 (TREM2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with Alzheimer’s disease (AD). The possible role of a related molecule, TREM1, in AD remains unknown. Objective: We investigated for TREM1 determining gene expression methylation levels leukocytes from patients. Methods: Fifty patients 50 age-matched healthy controls were enrolled. underwent battery neuropsychiatric tests. Peripheral...
<b><i>Background/Aims:</i></b> Age-related changes in impairments activities of daily living (ADL) older adults with very mild Alzheimer’s disease (vmAD) have been scarcely explored. We clarified the characteristics ADL impairment and examined how differed by age such patients compared community-dwelling cognitively normal adults. <b><i>Methods:</i></b> The participants were 107 vmAD (Mini-Mental State Examination [MMSE] score ≥24), all whom...