A5102935399- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Urinary Tract Infections Management
- Lung Cancer Diagnosis and Treatment
- Ginkgo biloba and Cashew Applications
- Biliary and Gastrointestinal Fistulas
- Parkinson's Disease Mechanisms and Treatments
- Abdominal Surgery and Complications
- Urologic and reproductive health conditions
- Colorectal Cancer Surgical Treatments
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Neurological Disease Mechanisms and Treatments
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Vascular Malformations and Hemangiomas
- Oral health in cancer treatment
- Vascular Tumors and Angiosarcomas
- Surgical site infection prevention
- Gallbladder and Bile Duct Disorders
- Parasitic infections in humans and animals
- Sarcoidosis and Beryllium Toxicity Research
Iwate Medical University
2019-2025
Kyoto University
2024
The Cancer Institute Hospital
2020
Sanofi (Japan)
2012-2013
Nishikawa Hospital
2005
Tokyo Metropolitan Komagome Hospital
2004
Saitama Medical University
1997-2002
Social Insurance Saitama Chuo Hospital
1997-2002
Saitama International Medical Center
1998
Tokyo Women's Medical University
1995
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
Abstract Background Artificial intelligence (AI) has made remarkable progress in image recognition using deep learning systems. It been used to detect esophageal squamous cell carcinoma (ESCC); however, none of the previous reports were investigations a clinical setting, being retrospective design. We therefore conducted this trial determine how AI can help endoscopists ESCC setting. Methods This was prospective, single-center, exploratory, and randomized controlled trial. High risk patients...
In Brief Objective: We compared the clinical efficacy of barium therapy and conservative in preventing recurrence patients with diverticular bleeding. Background: Previous case reports have indicated that impaction provides initial hemostasis for bleeding prevention against rebleeding. Methods: After spontaneous cessation bleeding, were randomly assigned to treatment (n = 27) or high-dose 27). Patients followed up 1 year after enrollment last patient. The main outcome measure was Results:...
The aim of the study was to investigate factor adverse reactions related compliance with Mycobacterium bovis bacillus Calmette-Guérin maintenance therapy in patients high-risk non-muscle-invasive bladder cancer.This a post hoc analysis using database randomized controlled trial that examined efficacy (Connaught strain) therapy. Among 42 assigned group, six dropped out or withdrew consent before and clinical backgrounds remaining 36 who underwent were compared between two groups: completed...
Metastatic spermatic cord (SC) tumor is extremely rare. Recently, we experienced a case of late-onset metastatic SC from cecal cancer. This 68-year-old man presenting with painless right mass. He had undergone hemicolectomy for cancer 6 years ago. Radical orchiectomy and adjuvant chemotherapy S-1 were performed. No recurrence was found after one year follow-up. We identified total 25 cases, including our case, on literature search via PubMed January 2000 to April 2015. The most frequent...
症例は77歳,女性.嘔気,嘔吐,腹痛のため当院受診した.腹部単純X線写真,腹部超音波検査にてイレウスと診断し入院した.腹部CTでは骨盤内左側の小腸内に径約3cmの石灰化を有する陰影を認めた.イレウス管造影でも同部回腸に腫瘤状の陰影欠損を認め,閉塞していた.腸石による閉塞性イレウスと診断し開腹術を施行した.回腸末端から約60cmの部位に閉塞部位を認め,結石様腫瘤を触知した.小腸部分切除を施行した.切除標本にて,4.5×3.5×2.0cmの腸石を認めた.結石成分分析にて胆汁酸結石と考えられた.術後の消化管透視,上部消化管内視鏡検査にて十二指腸水平脚に径3~6cmの憩室を数室認め,各憩室内に結石を認めた.また,術前後のCT,US,MRCPで胆道系異常は認めなかった.以上から,十二指腸憩室内結石の墜落によるイレウスと考えられた.十二指腸憩室内結石落下嵌頓による腸石イレウスは本邦では2例目であった.
結腸内分泌細胞癌の悪性度と治療法を考察するうえで興味ある症例を経験したので報告する. 症例は38歳, 女性. 3型横行結腸癌に対し, 結腸左半切除術 (D3), 腹壁合併切除を施行した. 病理組織学的検索では, 低分化型腺癌の形態を示す細胞の増殖が主体で, 免疫染色では, chromogranin Aおよびsynaptophysinが陽性であり, 内分泌細胞癌, pSE, ly1, v3, pN1, sH0, cP0, cM0, f Stage IIIaと診断した. 術後補助化学療法としてUFTの内服を開始したが, 2カ月で急速に増加する腹水と腸間膜に径5cm前後の多発リンパ節転移を認めた. 化学療法を塩酸イリノテカン (CPT-11) に変更したが, 術後9カ月で原癌死した. 原発巣のvascular endothelial growth factor (VEGF), VEGF-C, thymidine phosphorylaseの蛋白量をenzyme-linked immunosorbent assay法で測定したところ, これらの値は同時期のstage...
4000 Background: It has long been controversial whether LT is superior to AT for two subtypes of esophago-gastric junctional (EGJ) tumors, true cardia (TC) and sub-cardia (SC) cancer. In many reports showed better survival but with increased morbidity. To evaluate the superiority over AT, we conducted a RCT. Methods: Eligibility criteria included histologically proven adenocarcinoma, clinical T2–4 esophageal invasion 3 cm or less, 75 younger age, no distant metastasis, sufficient organ...
A 59-year-old man with medical history of diabetes mellitus and hypertension presented a persistent fever unknown origin developed headache. Laboratory tests, including polymerase chain reaction assays for Mycobacterium tuberculosis, showed no specific abnormal findings in blood or cerebrospinal fluid. Contrast-enhanced computed tomography revealed abdominal paraaortic lymphadenopathy. Abdominal lymph node biopsy caseous necrosis suggested tuberculous Intensive examinations positive...
Parkinson's disease (PD) is more prevalent in the aging population, and epidemiological evidence must be constantly updated to provide an accurate understanding of PD prevalence. Various nonmotor symptoms precede onset motor prodromal PD. The detection such crucial yet remains challenging. In this study, we aimed clarify current prevalence PD.We enrolled 714 community-dwelling older adults (330 men 384 women) aged ≥ 65 years (mean age 76.3 years). We used a self-administered questionnaire...
症例は62歳，女性．半年前より10日に1回程度，数時間の左骨盤部激痛発作を繰り返し，近医婦人科にて精査するが，異常を認めず原因不明とされた．その後も症状を繰り返し，近医にて腹部MRI検査施行．左恥骨筋と外閉鎖筋の間にT1強調画像T2強調画像にて高信号の腫瘤性陰影を認め，当院紹介受診．当院腹部CTでも同部位に腫瘤性陰影を認めた．臨床経過，画像所見より大網等が脱出，自然還納を繰り返した閉鎖孔ヘルニアと診断した．開腹手術施行．開腹時所見にて左閉鎖孔部位にヘルニア開口部を認め，臓器の嵌頓は認めなかった．Richter型ヘルニアに見られる小腸狭窄は認めず，卵巣も固定されており，小腸や卵巣の嵌頓であった可能性は低いと考えられた．大網は骨盤部まで下垂しており，大網の閉鎖孔ヘルニアであったことが最も考えられた．閉鎖孔ヘルニア根治術を施行した．術後症状は改善しており，左閉鎖孔ヘルニアに大網等が嵌頓自然還納を繰り返し，疼痛発作の原因となっていたと考えられた．通常，閉鎖孔ヘルニアは小腸の嵌頓イレウスで発症し診断されることがほとんどであり，本症例のように発症から半年間イレウス症状なく，疼痛発作症状を繰り...
Background and Objectives: Detection evaluation of carotid plaque using conventional two-dimensional (2D) ultrasonography is not sufficient for evaluating the three-dimensional extent plaque. We have therefore been applying latest technique (3D) to observe aspects The present study was performed compare morphological changes in before during treatment with fluvastatin 3D ultrasonography.Methods: subjects were 13 patients (M:F = 9:4,65 ± 11 years old). Serum LDL cholesterol levels these...
4000 Background: It has long been controversial whether LT is superior to AT for two subtypes of esophago-gastric junctional (EGJ) tumors, true cardia (TC) and sub-cardia (SC) cancer. In many reports showed better survival but with increased morbidity. To evaluate the superiority over AT, we conducted a RCT. Methods: Eligibility criteria included histologically proven adenocarcinoma, clinical T2–4 esophageal invasion 3 cm or less, 75 younger age, no distant metastasis, sufficient organ...
症例は81歳，男性．既往に認知症・高血圧・脳梗塞後遺症・閉塞性動脈硬化症による左大腿切断術がある．2012年8月血便・嘔吐を主訴に当科受診した．腹部圧迫にて全体的に苦痛様表情を認めたが，明らかな腹膜刺激症状は認めなかった．腹部造影CTでは，広範な小腸腸管壁の気腫性変化，腹腔内遊離ガス，門脈ガスを認めた．腹腔内遊離ガス，門脈ガスを伴った腸管嚢腫様気腫症と診断した．腹部所見が軽微なこと，門脈ガスは少量であること，腸管気腫が小腸に限局していたことなどから，絶食・酸素投与・抗菌薬による保存的治療を行った．臨床症状，血液検査データは数日で軽快した．加療後14日目の造影CTでは腸管気腫・腹腔内遊離ガス・門脈ガスともに消失した．門脈ガス，腹腔内遊離ガスを伴った腸管嚢腫様気腫症では消化管壊死・穿孔の疑いから緊急手術も考慮されるが，小腸腸管嚢腫様気腫症の場合，その適応は慎重な判断を要することが示唆された．
Abstract: We performed laparoscopic wedge resection of the stomach in two patients with submucosal gastric tumor. Three trocars were inserted addition to a laparoscope. After blood vessels surrounding tumors had been ligated ENDO CUPs, we used GIA (a linear endoscopic stapling device) four times and then was performed. The operative time 3h33m Case 1 2.5h 2, bleeding minimal both cases. postoperative courses uneventful, intestinal peristalsis recovered rapidly wound pain. These results...
Memorization comprises three stages: encoding, storage, and retrieval. Using neuropsychological tests, we investigated the stage at which encoding storage are retained in Alzheimer's disease (AD) patients with progressive memory disorder.The target were an amnestic mild cognitive impairment (MCI) group (21 cases) FAST 4 (37 cases), 5 (10 6 (4 AD groups. The tests performed Rivermead behavioral test Wechsler scale-revised. These carried out MCI as well each group. We delayed recall (free cued...
We experienced a case of retroperitoneal cystic lymphangioma presenting with acute abdomen. A 24-year-old man was admitted to the hospital because abdominal pain and distention. Physical examination abdomen revealed tenderness, Abdominal plain roentgenogram showed shift transverse sigmoid colon right upper ultrasonography multilocular tumor showing echo pattern. computed tomography scan same tumor. An emergency operation performed diagnosis cyst. 30 × 14cm smooth surface arising in...
Lumboperitoneal or ventriculoperitoneal shunt insertion is a standard therapy for hydrocephalus that diverts cerebrospinal fluid from the subarachnoid space into peritoneal cavity. Gastrointestinal perforations due to this procedure occur rarely; however, accepted treatment strategies have not yet been established. Hence, most common approaches are open surgery spontaneous closure without endoscopy. We report case of small intestinal perforation in 73-year-old-woman occurred after...
胆管癌胆道再建術後の挙上空腸内結石はまれな疾患である．われわれは胆管癌術後20年目に約4.5cm の結石が挙上空腸内に嵌頓し胆管炎を繰り返した症例に対して外科的摘出術が奏効した1例を経験したので，文献的考察を加えて報告する．症例は92歳男性．20年前胆管癌にて肝右葉切除肝外胆管切除胆道再建術を施行（詳細不明）．2日前から発熱・肝機能障害認め当院受診した．CT・drip infusion cholecystocholangiography （DIC）-CTにて挙上空腸内巨大結石を認めた．胆道再建後挙上空腸内結石による胆管炎と診断し，保存的治療にて発熱，肝機能改善したが，その後も2回胆管炎を繰り返したため，手術施行した．挙上空腸を切開し，約4.5cmの結石を摘出した．切開部挙上空腸は直接縫合し，右側腹部へドレーンを留置した．術後経過は順調であった．
下部消化管手術における周術期抗菌薬投与の短縮化についてのprospective studyを行った。下部消化管待期手術症例74例を対象に, 術前24時間以内にpolyethylene glycol 2Lでmechanical cleansingを行った後, kanamycinlg+erythromycin 0.8gを3回経口投与した。加刀直前からcefotiamまたはcefmetazol1gを静注し, 3時間を超える手術では追加投与した。結腸手術では術当日ないし第2病日まで, 直腸手術では第2病日 (合計6g) までの投与に限定した。評価可能であった70例のsurgical site infectionはorgan/space infectionの3例 (4%) のみで, incisionalsite infectionは1例も認めなかった。MRSA感染はorgan/space infection2例, remote infection3例の合計5例 (7%) に認めたが, 重症例はなかった。以上の結果から, 下部消化管待期手術において,...