A5008442288- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Prion Diseases and Protein Misfolding
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological diseases and metabolism
- Nutritional Studies and Diet
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plant Extracts Effects
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Medicinal Plants and Neuroprotection
- Dental Health and Care Utilization
- EEG and Brain-Computer Interfaces
- Vitamin C and Antioxidants Research
- Health disparities and outcomes
- Ginkgo biloba and Cashew Applications
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Frailty in Older Adults
- Cholinesterase and Neurodegenerative Diseases
- Visual perception and processing mechanisms
- Vitamin K Research Studies
- Advanced MRI Techniques and Applications
Kanazawa University
2016-2025
Ricoh (Japan)
2022
Ishikawa Prefectural Central Hospital
2009-2010
Tonami General Hospital
2006
Tohoku University
2006
Objective The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted less decline on measures of cognition function than placebo. Herein, we aimed to characterize amyloid‐β (Aβ) protofibril (PF) captured by human cerebrospinal fluid (CSF) from living participants with different stages AD, which enable an enhanced understanding the dynamic changes lecanemab‐associated Aβ‐PF (Lec‐PF) vivo. Methods We newly developed a unique...
To evaluate the diagnostic reliability of cardiac iodine-123 metaiodobenzylguanidine ((123)I-MIBG) radioactivity in discriminating dementia with Lewy bodies (DLB) from Alzheimer disease (AD) regardless parkinsonism.The diagnosis DLB may be confounded by absence parkinsonism. This highlights need to improve accuracy antemortem without parkinsonism.Cardiac sympathetic denervation was examined using myocardial (123)I-MIBG scintigraphy 37 patients DLB, 42 AD, and 10 normal elderly controls. The...
We analysed the epidemiological data and clinical features of patients with prion diseases that had been registered by Creutzfeldt-Jakob Disease Surveillance Committee, Japan, over past 10 years, since 1999. obtained information on 1685 Japanese suspected as having judged 1222 diseases, consisting definite (n = 180, 14.7%) probable 1029, 84.2%) cases, except for dura mater graft-associated Creutzfeldt–Jakob disease which also included possible cases 13, 1.1%). They were classified into 922...
Our objective was to determine whether the consumption of green tea, coffee, or black tea influences incidence dementia and mild cognitive impairment (MCI) in older people. We conducted a population-based prospective study with Japanese residents aged >60 years from Nakajima, Japan (the Nakajima Project). Participants received an evaluation function blood tests. The also evaluated at baseline. Of 723 participants normal baseline survey (2007–2008), 490 completed follow up 2011–2013. during...
A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer's disease model) using DNA microarray analysis and that dopamine (DA)-signaling pathway was enhanced group fed RA versus controls. In cerebral cortex, levels monoamines, such as norepinephrine, 3,4-dihydroxyphenylacetic acid, DA, levodopa, increased after feeding. The expression DA-degrading enzymes, monoamine oxidase B...
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
The aim of this study was to evaluate the safety, tolerability and pharmacokinetics single dose Melissa officinalis extract which contained rosmarinic acid, including food-effects in healthy individuals. A total eleven individuals were randomly assigned treatment arms two studies [Study 1 (fasted state) Study 2 (fed state)]. Rosmarinic acid serum measured by a coulometric detection method using High-Performance Liquid Chromatography electrochemical detector. concentration peaked at hour...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
Abstract We conducted a randomized placebo-controlled double-blind 24-week trial using Melissa officinalis ( M. ) extract richly containing rosmarinic acid (RA) on patients with mild dementia due to Alzheimer’s disease (AD) the aim examine safety and tolerability (primary endpoint) of RA (500 mg daily) its clinical effects disease-related biomarker changes (secondary endpoints). Patients n = 23) diagnosed probable AD were either placebo or group. No differences in vital signs physical...
Abstract Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation amyloid β (Aβ); however, effect RA on tau phosphorylation and cognitive dysfunction remains unclear. The present study revealed that intake inhibited pathological hallmarks AD, including Aβ phosphorylated accumulation, improved function 3 × Tg-AD mouse model. Additionally, suppressed hippocampal inflammation...
Plasma amyloid-β (Aβ) markers are significant predictors of Aβ pathology. However, their prognostic value for cognition in patients with Alzheimer's disease (AD) is unknown. We compared plasma precursor protein (APP)
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder, mainly characterized by amyloid β (Aβ) accumulation in brain. Numerous new agents are currently undergoing clinical trials as disease-modifying therapies (DMTs) targeting Aβ. ALZ-801 a promising candidate DMT for AD, with phase 3 trial of ongoing specifically apolipoprotein E (APOE) ε4 homozygous patients early-stage AD. This study aimed to examine effects on Aβ assembly and explore its toxicological...
<b>Background: </b> A subset of patients with dura mater graft–associated Creutzfeldt–Jakob disease (dCJD) demonstrates atypical clinical features and plaque formation in the brain (plaque type). <b>Objective: To elucidate frequency type dCJD comparison non-plaque type. <b>Methods: We analyzed clinicopathologic findings 66 who had been registered as having by Disease Surveillance Committee, Japan, between April 1999 February 2006. <b>Results: 1) Analysis pathologically confirmed (n = 23)...
Alzheimer's disease (AD) commonly accompanies cerebral amyloid angiopathy (CAA).We aimed to reveal associations between CAA-related brain microbleeds and cerebrospinal fluid (CSF) markers in AD patients.Patients with probable (n = 88) from consecutive patients our memory clinic were evaluated for patient demographics, vascular risk factors, neuropsychological tests, apolipoprotein E phenotype, MRI including T2*-weighted image attenuated inversion recovery sequence, CSF tau markers.The 88...
Microbleeds (MBs) are frequently observed in Alzheimer's disease (AD); however, the relevance to AD pathophysiology has not been elucidated.We investigated correlation of MBs, especially cerebral amyloid angiopathy (CAA)-related MBs with cognitive function, gray matter volume, and glucose metabolism AD.We performed magnetic resonance imaging including T2*-weighted sequence for 206 patients AD. Among them, 158 no focal brain lesions except were tests, voxel-based morphometry,...
Amyloid-β (Aβ) aggregation intermediates, including oligomers and protofibrils (PFs), have attracted attention as neurotoxic aggregates in Alzheimer's disease. However, due to the complexity of pathway, structural dynamics intermediates how drugs act on them not been clarified. Here we used high-speed atomic force microscopy observe Aβ42 PF at single-molecule level effect lecanemab, an anti-Aβ antibody with positive results from Phase 3 Clarity AD. was found be a curved nodal structure...
<h3>Background and Objectives</h3> Epidemiologic evidence has shown that social isolation, a low frequency of contact with others, is associated the risk dementia late-life depressive symptoms. Therefore, we hypothesized may be involved in brain atrophy, symptoms play some role this relationship. We aimed to evaluate association between volumes various regions assess extent which mediate these relationships from large population-based multisite cohort study. <h3>Methods</h3> Dementia-free...
<i>Background/Aim:</i> Magnetic resonance imaging (MRI), cerebral blood flow single photon emission computed tomography (CBF-SPECT), fluorodeoxyglucose-positron (FDG-PET) and cerebrospinal fluid (CSF) biomarkers are used for the diagnosis of Alzheimer’s disease (AD). We aimed to reveal relative sensitivity these tools in a memory clinic setting. <i>Methods:</i> In 207 patients with probable AD our clinic, medial temporal lobe atrophy on MRI,...
Up to February 2008, a total of 132 patients with dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) have been identified in Japan, accounting for majority the world's dCJD. The received grafts from 1978 1993. Lyodura (B. Braun, Melsungen, Germany) was used all whom brand name could be identified. After incubation period 1 25 years (mean, 11.8 years), CJD appeared 1985 through 2006. We analyzed clinical, pathological, and molecular features 74 dCJD who had prospectively registered...