A5050447556- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- MRI in cancer diagnosis
- Cardiac electrophysiology and arrhythmias
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cardiovascular Function and Risk Factors
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Ion channel regulation and function
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Lanthanide and Transition Metal Complexes
- Prion Diseases and Protein Misfolding
- Genetic Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
Tokushima University Hospital
2014-2025
Fujita Health University
2016-2025
Fujita Health University Hospital
2017-2025
Japan Atomic Energy Agency
2025
Japan Proton Accelerator Research Complex
2025
Tokushima University
2015-2024
Japan Pediatric Society
2024
Japanese Circulation Society
2022
Kobe University Hospital
2021
Kanazawa University
2020
Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast regulation by Ca(2+)-permeable transient receptor potential canonical-3 (TRPC3) channels.Freshly isolated rat cardiac fibroblasts abundantly expressed TRPC3 had appreciable nonselective cation currents (I(NSC)) sensitive to a selective TPRC3 channel blocker, pyrazole-3 (3 μmol/L). Pyrazole-3 suppressed angiotensin II-induced Ca(2+) influx, proliferation,...
We analysed the epidemiological data and clinical features of patients with prion diseases that had been registered by Creutzfeldt-Jakob Disease Surveillance Committee, Japan, over past 10 years, since 1999. obtained information on 1685 Japanese suspected as having judged 1222 diseases, consisting definite (n = 180, 14.7%) probable 1029, 84.2%) cases, except for dura mater graft-associated Creutzfeldt–Jakob disease which also included possible cases 13, 1.1%). They were classified into 922...
Background— Recent evidence points to functional Ca 2+ -dependent K + (SK) channels in the heart that may govern atrial fibrillation (AF) risk, but underlying mechanisms are unclear. This study addressed role of SK repolarization and AF persistence a canine model. Methods Results— Electrophysiological variables were assessed dogs subjected remodeling by 7-day tachypacing (AT-P), as well controls. Ionic currents single-channel properties measured isolated cardiomyocytes patch clamp. NS8593,...
Coronary artery disease predisposes to atrial fibrillation (AF), but the effects of chronic ischemia/infarction on AF-related substrates are unknown.Regional right myocardial infarction (MI) was created in 40 dogs by ligating an that supplies free wall and not ventricles; 35 sham with same isolated ligated were controls. Dogs observed 8 days after MI subjected open-chest study, vitro optical mapping, and/or cell isolation for patch-clamp Ca(2+) imaging day 8. Holter ECGs showed more...
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) reportedly decreased the new-onset atrial arrhythmias in patients with type-2 diabetes (T2DM) or heart failure (HF). This study examined impact of SGLT2is on catheter ablation for fibrillation (AF) HF without T2DM. Persistent AF (PeAF) and (N-terminal prohormone brain natriuretic peptide, NT-proBNP ≥400 pg/ml) T2DM undergoing were prospectively enrolled (n = 102). prescribed from ≥1 month prior to procedure continued during follow-up 51...
The effect of worsening renal function and baseline chronic kidney disease (CKD) on outcomes in patients with coronary syndrome the setting optimal medical therapy remains unknown. REAL-CAD (Randomized Evaluation Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin Coronary Artery Disease) study is a prospective, multicenter, randomized trial high-dose (pitavastatin 4 mg/day) low-dose 1 statin 12 118 syndrome. primary end point was composite cardiovascular death, nonfatal...
Atrial fibrillation (AF) causes atrial-tachycardia remodeling (ATR), with enhanced constitutive acetylcholine-regulated K+ current (I(KAChC)) contributing to action potential duration shortening and AF promotion. The underlying mechanisms are unknown.To evaluate the role of protein-kinase C (PKC) isoforms in ATR-induced I(KAChC) activation.Cells from ATR-dogs (400-bpm atrial pacing for 1 week) were compared control dog cells. In vitro tachypaced (TP; 3 Hz) canine cardiomyocytes parallel 1-Hz...
The objectives of this study were to examine the reproducibility MEGA-editing J-difference technique and determine normal variation in γ-aminobutyric acid (GABA) level depending on cerebral region its fluctuation according menstrual cycle as baseline data for clinical application. participants consisted 15 adult volunteers (eight men seven women), all measurements repeated twice participants. pulses incorporated into point-resolved spectroscopy a 3 T instrument obtain editing spectra from...
Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate congestive heart failure (CHF) by generating tissue fibrosis. display robust ion currents, but their functional importance is poorly understood.To characterize fibroblast inward-rectifier K(+) current (IK1) remodeling CHF its effects on properties.Freshly isolated left fibroblasts were obtained from controls dogs with (ventricular tachypacing). Patch clamp was used record resting membrane...
The aim of this study was to investigate the effect timing valve surgery on clinical outcomes patients with active infective endocarditis (IE) accompanied by cerebral complications. We retrospectively analysed a cohort 568 patients, comprising 118 non-haemorrhagic infarction (CI), 54 intracranial haemorrhage (ICH) and 396 without events (C; control), who underwent for left-sided IE in 15 Japanese institutes from 2000 2011. mean age 58.4 ± 16.9 years CI group; 54.5 17.4 ICH group 56.9 16.0 C...