A5087489643- Retinal Diseases and Treatments
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- RNA Research and Splicing
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Mitochondrial Function and Pathology
- Biochemical and Molecular Research
- Electrocatalysts for Energy Conversion
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Diet, Metabolism, and Disease
- Connexins and lens biology
- Advanced Photocatalysis Techniques
- Advanced Nanomaterials in Catalysis
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Pain Mechanisms and Treatments
Gifu University
1996-2023
Gifu University Hospital
2016-2022
Hokkaido University
2018-2022
Gifu Prefectural General Medical Center
2019-2020
Tokyo University of Science
2015-2018
Kagoshima University
1987-2017
University of Miyazaki
2015
Terasaki Foundation
2015
Government of Japan
2015
Institute of Clinical Research
2013
Abstract Reduction of NiX2(PPh3)2 with zinc in the presence Et4NI gives a nickel catalyst which has been proven to be useful for coupling aryl halides. This can prepared THF without an additional triphenylphosphine and is effective homocoupling chlorides, bromides, iodides produce biaryls bipyridines good yields. The reported new approach provides simple access novel derivatives bipyridines.
To determine the relationship between retinal morphologic changes and concentrations of intravitreal cytokines in eyes with diabetic macular edema.A retrospective comparative study was performed. The preoperative optical coherence tomography images were evaluated to presence serous detachments (SRDs), cystic changes, swelling. vascular endothelial growth factor, interleukin (IL)-6, IL-8 vitreous samples collected during vitrectomy determined. correlations parameters, other clinical factors,...
We evaluated the effect of intravitreal triamcinolone acetonide (IVTA) or bevacizumab (IVB) on subfoveal choroidal thickness (SFCT) in eyes with diabetic macular edema (DME).In this prospective, randomized, interventional comparative study, 51 DME patients were randomized to receive either IVTA IVB. The central (CMT) and SFCT determined by optical coherence tomography at 24 hours, 7 days, 4, 8, 12 weeks. 1500 3000 μm nasal temporal fovea also was measured. values obtained before compared...
The reflectivity of optical coherence tomographic (OCT) images has been used to evaluate retinal diseases. purpose our study was determine whether a significant correlation exists between the subretinal fluid (SRF) and concentration intravitreal cytokines in eyes with diabetic macular edema (DME).A retrospective comparative done DME SRF before vitrectomy. determined from OCT images. Vitreous samples were collected during vitrectomy, analyzed for concentrations VEGF, IL-6, IL-8. To factors...
Abstract This study was performed to compare the area of foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. a cross-sectional, non-interventional twenty-seven healthy right eyes. The superficial and deep FAZ-area measured manually with OCTA instruments: Triton (Topcon), RS3000 (Nidek), CIRRUS (Zeiss). intra-rater, inter-rater, inter-instrument correlation coefficients (CC) were assessed. intra-rater inter-rater CC significantly...
The prevalence of Q fever pneumonia among children with atypical from whom only an acute-phase serum sample was available traced by using indirect immunofluorescence (IF) test, nested PCR, and isolation. Twenty (34.5%) 58 sera were found to have both polyvalent immunoglobulin M antibodies the phase II antigen Coxiella burnetii IF test. present in 23 (39.7%) patients as determined PCR isolation 20 sensitivities for 100%, that test 87%. Our results indicate faster more sensitive than diagnosis...
Asymmetrical secretion of vascular endothelial growth factor (VEGF) by retinal pigment epithelial (RPE) cells in situ is critical for maintaining the homeostasis retina and choroid. VEGF also involved development progression age-related macular degeneration (AMD). We studied effect tumor necrosis factor-α (TNF-α) on polarized non-polarized RPE (P-RPE N-RPE cells, respectively) culture rats. A subretinal injection TNF-α caused a decrease expression choroidal atrophy. Porcine were seeded...
To determine the role played by vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV) based on an interventional immunology theory.Eyes with PCV were divided a masked fashion into those hyperpermeability (HP group) and normal permeability (NP indocyanine green angiograms. The inter-rater agreement rate was evaluated using Fleiss' kappa. Patients treated intravitreal ranibizumab (IVB). central thickness foveal (CFT) at baseline 7 days after treatment measured...
Abstract Zerovalent nickel complex generated in situ by reduction of NiBr2(PPh3)2 with zinc powder the presence Et4NI was found to be an effective catalyst for homo-coupling benzyl halides. The catalytic reactions proceeded smoothly various solvents under mild conditions afford dehalogenative-coupling products good high yields.
Purpose.: Wedetermined the cause of sterile endophthalmitis after intravitreal triamcinolone acetonide (IVTA). Methods.: The clinical records 21 eyes that had IVTA were reviewed. Cytologic studies performed, and cytokine chemokine profiles in aqueous humor determined. effects a direct contact (TA) particles with cultured lens epithelial cells (B3) or retinal pigment (ARPE-19) on production Noncontact culture performed Boyden chamber; 11-deoxycortisol was used for nonbioactive particles....
To evaluate the individualized, optical coherence tomography-guided facedown posturing after macular hole (MH) surgery in minimizing burden and maximizing outcome.A retrospective comparative study. One hundred seven consecutive eyes with an MH (<500 μm) received vitrectomy gas tamponade. After surgery, tomography examination was performed from 6 hours to postoperative Day 2. In Group A, a pro re nata protocol, duration of determined findings. A subdivided as follows: A1, required...
To determine the permeability of bevacizumab and ranibizumab through highly-polarized retinal pigment epithelial (RPE) cells in vitro.Highly-polarized RPE were cultured upper chamber a Transwell culture system. Bevacizumab or was added to chamber. After 3 hours, concentrations determined lower chambers. The cytotoxicities two anti-vascular endothelial growth factor agents histologically. effects inhibiting endocytosis by pharmacologic inhibitors also evaluated.The concentration higher than...
Beta-ketothiolase deficiency is an inherited disorder of ketone body metabolism and isoleucine catabolism. It typically manifests as recurrent ketoacidotic episodes with characteristic abnormalities in the urinary organic acid profile. However, several challenges diagnosis beta-ketothiolase have been encountered: atypical presentations reported some other disorders, such succinyl-CoA:3-oxoacid CoA transferase 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiencies, can mimic clinical and/or...
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) is an autosomal recessive disease caused by mutations in the acetyl‑CoA acetyltransferase 1 (ACAT1) gene. A German T2‑deficient patient that developed a severe ketoacidotic episode at age of 11 months, was revealed to be compound heterozygote previously reported null mutation, c.472A>G (p.N158D) and novel c.949G>A (p.D317N), ACAT1. The mutation suspected cause aberrant splicing it located within exonic...