A5103223977- Amyotrophic Lateral Sclerosis Research
- Myasthenia Gravis and Thymoma
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Parkinson's Disease and Spinal Disorders
- Neurological and metabolic disorders
- Dysphagia Assessment and Management
- Vitamin C and Antioxidants Research
- Muscle Physiology and Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Glycogen Storage Diseases and Myoclonus
- Long-Term Effects of COVID-19
- Biotin and Related Studies
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- Nutritional Studies and Diet
Gifu Pharmaceutical University
2025
National Hospital for Neurology and Neurosurgery
2024
University College London
2024
National Hospital Organization
2012-2022
National Hospital
2013
International Neuromodulation Society
2013
Kanazawa University
1998-2009
Niigata University
2004
National Institute for Physiological Sciences
2000
Kanazawa Hospital
2000
Our objective was to determine whether the consumption of green tea, coffee, or black tea influences incidence dementia and mild cognitive impairment (MCI) in older people. We conducted a population-based prospective study with Japanese residents aged >60 years from Nakajima, Japan (the Nakajima Project). Participants received an evaluation function blood tests. The also evaluated at baseline. Of 723 participants normal baseline survey (2007–2008), 490 completed follow up 2011–2013. during...
Abstract Background Rare neuromuscular diseases such as spinal muscular atrophy, bulbar dystrophy, Charcot-Marie-Tooth disease, distal myopathy, sporadic inclusion body myositis, congenital and amyotrophic lateral sclerosis lead to incurable amyotrophy consequent loss of ambulation. Thus far, no therapeutic approaches have been successful in recovering the ambulatory ability. Thus, aim this trial was evaluate efficacy safety cybernic treatment with a wearable cyborg Hybrid Assistive Limb...
<h3>Importance</h3> The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin be promising agent. <h3>Objective</h3> To validate the efficacy and safety patients with ALS enrolled within 1 year onset. <h3>Design, Setting, Participants</h3> This was multicenter, placebo-controlled, double-blind, randomized phase 3 clinical trial 12-week observation...
Duchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy tolerability ivabradine treatment for cardiomyopathy.A retrospective analysis performed in 11 patients DMD, who received more than 1 year. Clinical results were analyzed before (baseline), 6...
Metallothionein (MT) is a small-molecule protein that functions in essential trace element homeostasis. Among MT isoforms, MT3 involved neuronal activity, and its expression reported to be decreased patients with neurodegenerative conditions such as Alzheimer's disease; however, only few effective drugs have been induce expression. In this study, we evaluated existing for the induction of cell line ReNcell CX cells. Using recombinant proteins isoforms 3× Flag tag, performed Western blotting...
An increasing elderly population in Japan requires effective cognitive intervention programs for dementia. This study demonstrates the effectiveness of such older adults.The participants were local community-dwelling non-demented adults and with mild impairment who underwent executive function group aerobic training. In addition, a non-intervention participated activity sessions involving handicraft, Skutt ball matches, cooking. The four criteria assessment function, instrumental activities...
Abstract The possible antigenicity of synaptotagmin, a synaptic vesicle protein acting as cooperative calcium (Ca 2+ ) receptor in exocytosis, was tested to determine whether it is involved the induction Lambert‐Eaton myasthenic syndrome which antibodies against voltage‐dependent Ca channels or related molecules play pathogenic role. Repeated injections Lewis rats with peptides synaptotagmin residues 20 through 53 1 30 that are presumably exposed at nerve terminal surface during exocytosis...
Significant differences exist in demographic characteristics between responders and non-responders population-based studies on mental health cognitive status, but much less is known regarding the prevalence of dementia cogni
Although several studies have demonstrated a potential correlation of dietary patterns with cognitive function, the relationship between tooth loss and function not been identified. In this cross-sectional study, we used reduced rank regression (RRR) analysis, technique previously to observe based on intakes nutrients or levels biomarkers associated condition interest, identify loss-related investigate associations such impairment in 334 community-dwelling Japanese subjects aged ≥ 60 years....
Antioxidants like vitamins C and E may minimize the risk for Alzheimer's disease.We examined whether modify apolipoprotein (APOE) E4-related risks developing cognitive decline.We conducted a population-based prospective study including Japanese residents aged 65 years from Nakajima, Japan. The participants received an evaluation of function underwent blood tests levels APOE phenotypes. E4-by-gender-by-vitamin or interactions on decline were analyzed.Of 606 with normal determined using...
Glucose dysmetabolism is an important risk factor for dementia.We investigated the associations of diabetes mellitus, levels glycemic measures, and insulin resistance secretion measures with dementia its subtypes in a cross-sectional study.In this study, 10,214 community-dwelling participants were enrolled. Hemoglobin A1c (HbA1c), homeostasis model assessment (HOMA) (HOMA-IR), HOMA percent β-cell function (HOMA-β), glycated albumin (GA) was evaluated. The each measure Alzheimer's disease...
To search for antigenic sites in the molecular structure of alA subunit voltage-gated calcium channel (VGCC) (P/Q-type) Lambert-Eaton myasthenic syndrome (LEMS), we studied by immunoprecipitation assay serum samples from 30 LEMS patients (16 with small cell lung carcinoma (SCLC), 20 disease controls (10 SCLC without and 10 myasthenia gravis), 15 healthy controls. Synthetic peptide antigens corresponded to extracellular region (S5-S6 linker region) each four domains forming al P/Q-type VGCC....
The authors examined blood pressure, glucose, insulin, and neurotensin before after intake of 75 g glucose with or without voglibose in 28 neurologic patients 20 healthy controls. Voglibose significantly prevented hypotension increment had no influence on insulin increment. These results suggest that benefits postprandial hypotension.
The mechanism of muscle weakness in myasthenia gravis and its possible relation to antibodies that are directed against the ryanodine receptor (RyR) were studied by use spontaneous thymoma rat (Buffalo/Mna strain). present study focused on motor dysfunction as complicated impaired subcellular machineries noted particularly patients with thymus abnormalities. Rats began develop skeletal soon after birth worsened progressively. aged 3 months showed a benign characterized proliferative...
ABSTRACT Objective To evaluate the effectiveness of an electric toothbrush for oral care in patients with neuromuscular disability. Methods In this randomized observer‐blind crossover trial, 30 disease performed either or manual toothbrushing each 4 weeks. Plaque status (plaque control record), periodontal pocket depth, (oral assessment guide), salivary bacterial count, and time were assessed after period compared between two groups by Wilcoxon signed‐rank test. Results Twenty‐eight...