A5061628159- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Parathyroid Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Thyroid and Parathyroid Surgery
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Medical Imaging and Pathology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Trace Elements in Health
- Nicotinic Acetylcholine Receptors Study
- Endoplasmic Reticulum Stress and Disease
- Pluripotent Stem Cells Research
- Genetic Syndromes and Imprinting
- Neurological disorders and treatments
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Neurogenetic and Muscular Disorders Research
- Biochemical and biochemical processes
- biodegradable polymer synthesis and properties
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neurological diseases and metabolism
Gifu Pharmaceutical University
2016-2025
Kyoto Pharmaceutical University
2004-2016
Ritsumeikan University
2010-2011
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily characterized by the degeneration of dopaminergic neurons in nigrostriatal pathway. Previous studies have demonstrated chronic systemic exposure Lewis rats to rotenone produced many features PD, and cerebral tauopathy was also detected case severe weight loss. The present study designed assess neurotoxicity after daily oral administration for 28 days at several doses C57BL/6 mice. In addition, we examined...
Chronic systemic exposure of Lewis rats to rotenone produced many features Parkinson's disease (PD), including nigrostriatal dopamine (DA) neurodegeneration and the formation cytoplasmic inclusions in nigral DA neurons. We also reported that chronic oral administration at 30 mg/kg for 28 d caused specific C57BL/6 mice. To establish a PD model more suitable evaluating neurodegeneration, present study has been designed assess neurotoxicity after daily or 100 56 The survival rate...
Labile heme (LH) is a complex of Fe(II) and protoporphyrin IX, an essential signaling molecule in various biological systems. Most the subcellular dynamics LH remain unclear because lack efficient chemical tools for detecting cells. Here, we report activity-based fluorescence probe that can monitor fluctuations events. H-FluNox selective fluorescent senses using biomimetic N-oxide deoxygenation to trigger fluorescence. The selectivity >100-fold against Fe(II), enabling discrimination from...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron cell death. A GGGGCC hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72 (C9orf72) gene major causative factor in ALS. This abnormal HRE triggers five types of dipeptide protein (DPR), each composed two alternating amino acid expressions. Among DPRs, arginine-rich Poly-PR localizes predominantly to nucleus, exerting particularly strong toxicity on and...
Abstract Planarian, an invertebrate flatworm, has a high capacity for regeneration when compared with other worms and animals. We show here the first time that reconstructed dopamine (DA) neural network regulates locomotion behavior in planarian regenerates. The gene encoding tyrosine hydroxylase Dugesia japonica ( DjTH ) was identified. protein coexpressed aromatic amino acid decarboxylase‐like A (DjAADCA) central nervous system (CNS). In addition, ‐knockdown planarians lost ability to...
Abstract Parkinson's disease (PD) is the second most common neurodegenerative and characterized by dopaminergic (DA) neuronal cell loss in substantia nigra. Although entire pathogenesis of PD still unclear, both environmental genetic factors contribute to neurodegeneration. Epidemiologic studies show that prevalence lower smokers than nonsmokers,. Nicotine, a releaser dopamine from DA neurons, one candidates antiparkinson agents tobacco. To assess protective effect nicotine against...
Reactive oxygen species (ROS) is massively produced in the brain after cerebral ischemia and reperfusion. It reacts strongly with cellular components, which has detrimental effects leads to neuronal cell death. DJ-1, was found be causative gene of familial Parkinson's disease PARK7, a multifunction protein, plays key role transcriptional regulation, molecular chaperone. In this study, we investigated neuroprotective effect DJ-1 against neurodegeneration caused by ischemia/reperfusion injury....
Iron is involved in numerous physiologically essential processes our body. However, excessive iron a pathogenic factor neurodegenerative diseases, causing aberrant oxidative stress. Divalent metal transporter 1 (DMT1) acts as primary of Fe(ii) ions. The intracellular delivery DMT1 toward the cellular membrane via trans-Golgi network during endocytotic process partially regulated by retromer-mediated protein-sorting system comprising vacuolar proteins (VPSs). Thus, together with DMT1,...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. The purpose this study was to clarify effects brazilian green propolis active ingredient against ALS-associated mutant copper-zinc superoxide dismutase (SOD1)-mediated toxicity. Ethanol extract (EBGP) protected N2a cells SOD1-induced neurotoxicity reduced aggregated SOD1 induction autophagy. Kaempferide kaempferol, ingredients EBGP, also...
Parkinson's disease is characterized by dopaminergic neuronal death and the presence of Lewy bodies. α-Synuclein a major component bodies, but process its accumulation relationship to has not been resolved. Although pathogenesis clarified, mitochondrial complex I suppressed, caspase-3 activated in affected midbrain. Here we report that combination 1-methyl-4-phenylpyridinium ion (MPP+) or rotenone proteasome inhibition causes appearance α-synuclein-positive inclusion Unexpectedly, however,...
Abstract Parkinson’s disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors degradation have been used for PD therapy, death progresses during treatment. DJ‐1, causative gene product familial form PD, PARK7, plays roles in transcriptional regulation anti‐oxidative stress, loss its function thought to result the onset PD. Superfluous oxidation cysteine at amino acid 106 (C106) DJ‐1 renders inactive, such oxidized has observed patients with sporadic In...
The loss of homeostasis essential metals is associated with various diseases, including neurodegenerative diseases. Previous studies have shown that the levels zinc (Zn) are significantly higher in cerebrospinal fluid patients amyotrophic lateral sclerosis (ALS). Zn transporters and metallothioneins tightly control intracellular extracellular levels. This study investigated protein ZnT, a transporter family, ALS model mice. mRNA expression ZnT1, −3, −4, −5, −6, −7, −10 was assessed spinal...
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra. The pathological hallmark PD appearance intraneuronal cytoplasmic α-synuclein (α-Syn) aggregation, called Lewy bodies. α-Syn aggregation deeply involved pathogenesis PD. Oxidative stress also associated with progression In present study, to investigate whether hypoxia-inducible factor (HIF)-prolyl hydroxylase (PH) inhibitor, FG-4592 (also roxadustat), has...
Metallothionein (MT) is a small-molecule protein that functions in essential trace element homeostasis. Among MT isoforms, MT3 involved neuronal activity, and its expression reported to be decreased patients with neurodegenerative conditions such as Alzheimer's disease; however, only few effective drugs have been induce expression. In this study, we evaluated existing for the induction of cell line ReNcell CX cells. Using recombinant proteins isoforms 3× Flag tag, performed Western blotting...
Abstract Neuron/glial 2 (NG2)‐expressing cells are often referred to as oligodendrocyte precursor cells. NG2‐expressing have also been identified multipotent progenitor However, microglia‐like NG2 glial not fully examined in neurodegenerative disorders such Parkinson's disease (PD). In the present study, we chose two rat models of PD, i.e., intranigral or intrastriatal injection 6‐hydroxydopamine (6‐OHDA), since cell bodies dopamine (DA) neurons, which form a nigrostriatal pathway,...