A5055051416- Neurogenetic and Muscular Disorders Research
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Microstructure and Mechanical Properties of Steels
- Genetic Neurodegenerative Diseases
- Semiconductor Quantum Structures and Devices
- RNA Research and Splicing
- Congenital Anomalies and Fetal Surgery
- Metal Alloys Wear and Properties
- Marine Toxins and Detection Methods
- Metallurgy and Material Forming
- Mitochondrial Function and Pathology
- Prosthetics and Rehabilitation Robotics
- Oral and Maxillofacial Pathology
- Long-Term Effects of COVID-19
- Parkinson's Disease Mechanisms and Treatments
- GaN-based semiconductor devices and materials
- Quantum and electron transport phenomena
- Amyotrophic Lateral Sclerosis Research
- Cardiomyopathy and Myosin Studies
- Sarcoma Diagnosis and Treatment
- Environmental Toxicology and Ecotoxicology
- Semiconductor materials and devices
- Adipose Tissue and Metabolism
- Cancer Diagnosis and Treatment
National Hospital Organization
2016-2025
Toneyama National Hospital
2016-2025
Osaka City General Hospital
2021-2023
Tokai University
1997-2022
College of Industrial Technology
1999-2022
Nihon University
1999-2022
Osaka University
2000-2018
Oita University
2018
Yokohama Rosai Hospital
2018
Osaka University of Human Sciences
2018
Left ventricular (LV) midwall geometry has been described conventionally as the sum of chamber radius and half wall thickness; this convention is based on assumption uniform transmural thickening during systole. However, theoretical considerations experimental data indicate that inner (inner shell) LV thickens more than outer (outer shell). Thus, an end-diastolic circumferential fiber exhibits a relative migration toward epicardium As result, conventional method provides overestimate extent...
Abstract Background Rare neuromuscular diseases such as spinal muscular atrophy, bulbar dystrophy, Charcot-Marie-Tooth disease, distal myopathy, sporadic inclusion body myositis, congenital and amyotrophic lateral sclerosis lead to incurable amyotrophy consequent loss of ambulation. Thus far, no therapeutic approaches have been successful in recovering the ambulatory ability. Thus, aim this trial was evaluate efficacy safety cybernic treatment with a wearable cyborg Hybrid Assistive Limb...
Duchenne muscular dystrophy (DMD) is a genetic muscle disorder that manifests during early childhood and ultimately fatal. Recently approved treatments targeting the cause of DMD are limited to specific subpopulations patients, highlighting need for therapies with wider applications. Pharmacologic inhibition myostatin, an endogenous inhibitor growth produced almost exclusively in skeletal muscle, has been shown increase mass several species, including humans. Taldefgrobep alfa anti-myostatin...
We have calculated the atomic structure and strain energy of ${\mathrm{In}}_{x}{\mathrm{Ga}}_{1\ensuremath{-}x}\mathrm{N}$ random alloy $(0<~x<~1)$ based on $592\ensuremath{\sim}13240$-atom models. A valence-force-field method with Keating potential is used for calculation. analyzed bond-length bond-angle distribution in due to fluctuation atom positions. The change average Ga--N In--N bond lengths as a function composition x. result good agreement recent experimental data extended...
We have investigated Zeeman splitting in single self-assembled InAs and InGaAs quantum dots experimentally theoretically. By measuring photoluminescence from dots, a wide spectral region, we obtained the exciton $g$ factors of with various energies. find that absolute value are smaller than those which differs composition dependence expected bulk ones. The compared calculated ones based on eight-band $\mathbf{k}∙\mathbf{p}$ model where influence strain effect included. good agreement between...
<h3>Objective and methods</h3> Dysferlin encoded by <i>DYSF</i> deficiency leads to two main phenotypes, limb girdle muscular dystrophy (LGMD) 2B Miyoshi myopathy. To reveal in detail the mutational clinical features of LGMD2B Japan, we observed 40 Japanese patients 36 families with whom dysferlin mutations were confirmed. <h3>Results conclusions</h3> Three (c.1566C>G, c.2997G>T c.4497delT) relatively more prevalent. The mutation was associated late onset, proximal dominant forms...
Abstract Background Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disease caused by insufficient functional survival motor neuron protein (SMN). The SMN expression level in the spinal cord highest during 2nd trimester of foetal period. We previously reported spot analysis peripheral blood using imaging flow cytometry (IFC) as biomarker expression. In this study, we analysed neonatal blood, postnatal and maternal presymptomatic five infants whose sibling has type 1 SMA to...
Electrochemically generated hydrogen gas was used to measure local blood flow by Stosseck et al. The data obtained their method, however, did not correlate well with those inhalation. We have modified the equation proposed Stosseck, prolonging stimulus duration in order increase amount of generated. In dog white matter resulting clearance curves were formed be monoexponential both living animal as after circulatory arrest when all is diffusion away from electrode. values calculated our correlated
We have theoretically studied the optical polarization in columnar InAs/GaAs quantum dots (QDs), which self-assembled QDs are vertically stacked with no interdot spacing. The model structure of consists truncated-cone-shaped InAs stacking-layer numbers (SLNs) 1, 3, 5, 7, and 9. used valence-force-field to calculate strain distribution. find that biaxial middle layers decreases increasing SLN becomes negative for $\text{SLN}=9$. This is due condition vertical lattice constant these has match...
当院を受診し1977~2010年に死亡したDuchenne muscular dystrophy患者の死因を分析した.1984年に開始した呼吸管理や,1990年代以降の心保護治療をふくむ積極的加療の結果,平均死亡年令は1984年以前の18.9歳が2004年以降は31.1歳に延長し,さらなる延命が予測される.呼吸管理の長期化や在宅人工呼吸療法患者の増加から,二次性肺障害予防とリスクマネジメントが重要になっている.約半数を占めていた呼吸不全死は激減し,心不全が主要死因となった.心保護治療の進歩で拡張型心筋症によるうっ血性心不全が減少したが,循環不全による腎不全が出現しており,心腎連関への配慮が重要である.
Objective Heart failure is currently the most serious complication of muscular dystrophy. The transient receptor potential cation channel, subfamily V, member 2 (TRPV2) a stretch-sensitive Ca channel. In damaged myocytes or cardiomyocytes, TRPV2 translocates to cytoplasmic membrane and enhances influx, triggering cell damage. Evidence suggests that inhibition may be new therapeutic target in heart failure. We found tranilast, which widely used as an anti-allergic drug, inhibits TRPV2. A...