A5006021627- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury Research
- Biosimilars and Bioanalytical Methods
- Lysosomal Storage Disorders Research
- Eosinophilic Disorders and Syndromes
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trypanosoma species research and implications
- Spinal Dysraphism and Malformations
- Dialysis and Renal Disease Management
- Advanced Breast Cancer Therapies
- COVID-19 Clinical Research Studies
- Tissue Engineering and Regenerative Medicine
- Cerebrospinal fluid and hydrocephalus
- COVID-19 and healthcare impacts
Mexican Social Security Institute
2025
Hospital Universitario Virgen Macarena
2015-2025
Foundation for Transport and Energy Research and Development
2023
Isabela State University
2023
Instituto de Oncología y Radiobiología
2021
Hospital Clínic de Barcelona
2019
Hospital Universitario Puerta de Hierro Majadahonda
2010-2018
Hospital General Universitario Gregorio Marañón
2017
Hospital de Clínicas "José de San Martín"
2016
Rafael Advanced Defense Systems (Israel)
2013
<h2>Abstract</h2><h3>Background aims</h3> Cell therapy with mesenchymal stromal cells (MSCs) offers new hope for patients suffering from spinal cord injury (SCI). <h3>Methods</h3> Ten established incomplete SCI received four subarachnoid administrations of 30 × 10<sup>6</sup> autologous bone marrow MSCs, supported in plasma, at months 1, 4, 7 and 10 the study, were followed until month 12. Urodynamic, neurophysiological neuroimaging studies performed 6 12, compared basal studies....
Cell therapy with autologous mesenchymal stromal cells (MSCs) in patients spinal cord injury (SCI) is beginning, and the search for its better clinical application an urgent need.We present a phase 2 trial chronic SCI who received three intrathecal administrations of 100 x 106 MSCs were followed 10 months from first administration. Efficacy analysis was performed on nine patients, safety 11 patients. Clinical scales, urodynamic, neurophysiological neuroimaging studies previous to treatment...
Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 2021 by the Spanish transplant cell therapy group was used analyze relationship at 3–6 weeks after full vaccination (2 doses) with breakthrough infection 1394 disorders. Results At a median follow-up 165 days...
Duchenne muscular dystrophy (DMD) is a genetic muscle disorder that manifests during early childhood and ultimately fatal. Recently approved treatments targeting the cause of DMD are limited to specific subpopulations patients, highlighting need for therapies with wider applications. Pharmacologic inhibition myostatin, an endogenous inhibitor growth produced almost exclusively in skeletal muscle, has been shown increase mass several species, including humans. Taldefgrobep alfa anti-myostatin...
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Recent researches show that fish 1 of the most important triggers FPIES in Mediterranean countries. Due risk multiple-food FPIES, avoiding foods same category often occur together may be reasonable. The aim this study was evaluate evolution and follow-up related over period 20 years. We describe clinical features our population, discuss different...
Ibrutinib demonstrated remarkable efficacy and favorable tolerability in patients with untreated or relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), including those high-risk genetic alterations. The IBRORS-CLL study assessed the characteristics, clinical management outcome of CLL receiving ibrutinib routine practice Spain.Observational, retrospective, multicenter who started single-agent as first-line treatment at first second relapse between January 2016 2019.A total 269 were...
Currently, it is accepted that brain injury promotes endogenous neurogenesis in mammals, primarily the subventricular zone (SVZ), and newborn cells can migrate to injured area. We examined pattern of adult rats after intracerebral hemorrhage (ICH) was caused by intrastrial administration collagenase type IV. Our results showed ICH induced strong between 72 hours 7 days injury, but majority did not survive longer than 3 weeks due apoptosis-mediated cell death. Furthermore, remained into a...
Invasive mould infections are a significant cause of morbidity and mortality in pediatric cancer patients, particularly those undergoing aggressive myeloablative chemotherapy. Voriconazole has been described as an appropriate effective prophylactic agent adults with cancer.We compared the etiology, predisposing factors outcomes invasive infection patients treated for acute myeloid leukemia before after implementation voriconazole prophylaxis center.We observed no difference number between...
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Currently, there no effective strategy to treat the functional sequelae associated with TBI. Experimental evidence shows that intravenous administration bone marrow stromal cells (BMSC) during first week after TBI prevents neurological deficits, but experimental studies have shown effect BMSC on chronic sequelae. Here we studied outcomes 2 months in rats. Adult Wistar rats were subjected weight-drop impact...
In chronic myeloid leukemia (CML) patients, 3-month BCR-ABL1 levels have consistently been correlated with further outcomes. Monitoring molecular responses in CML using the GeneXpert (Cepheid) platform has shown an optimal correlation standardized RQ-PCR (IS) when measuring lower than 10%, as it is not accurate for values over 10%. The aim of present study was to determine predictive value at three months on different outcome variables Xpert MonitorTM assay (Xpert BCR-ABL1). We monitored 125...
The quantification of enzyme activity in the patient treated with replacement therapy (ERT) has been suggested as a tool for dosage individualization, so we conducted study to evaluate relationship between glucocerebrosidase and clinical response patients Gaucher disease type I (GD1) ERT. included diagnosed GD1, who were being ERT, healthy individuals. Markers based on measurement patients' leucocytes studied: at 15 min. post-infusion (Act75 ) reflects amount that is distributed body...
In the present work, effectiveness of four non-halogenated flame retardants (FR) (aluminium trihydroxide (ATH), magnesium hydroxide (MDH), Sepiolite (SEP) and a mix metallic oxides hydroxides (PAVAL)) in blends with recycled acrylonitrile-butadiene-styrene (rABS) was studied order to develop more environmentally friendly flame-retardant composite alternative. The mechanical thermo-mechanical properties obtained composites as well their mechanism were evaluated by UL-94 cone calorimetric...
GABRIELL was a phase II single-arm study to evaluate the efficacy and safety of obinutuzumab plus bendamustine for relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). Seventy-two patients with active disease received treatment up six 28-day cycles. Overall response rate 78.6% median progression-free survival (PFS) 26 months, overall (OS) not reached at end follow-up (36 months). Undetectable measurable residual (≤0.01%; 36.4% in bone marrow 53.4% peripheral blood) correlated...