A5047882021- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Patient Safety and Medication Errors
- Erythropoietin and Anemia Treatment
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Treatments and Studies
- Histiocytic Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Public Health in Brazil
- Lysosomal Storage Disorders Research
- Anesthesia and Sedative Agents
- Cancer Treatment and Pharmacology
- Health and Medical Education
- Tuberous Sclerosis Complex Research
- Pharmaceutical Economics and Policy
- Safe Handling of Antineoplastic Drugs
- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Economic and Financial Impacts of Cancer
- Rheumatoid Arthritis Research and Therapies
- Antibiotics Pharmacokinetics and Efficacy
Hospital Universitario Doctor Peset
2016-2025
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2022-2024
Universitat de València
2008-2023
Hospital Clínico Universitario de Valencia
2016
University of Geneva
1971-1990
Medication discrepancies, defined as unexplained variations among drug regimens at care transitions, are common. Some unintended and cause reconciliation errors that potentially detrimental for patients.To determine the prevalence of medication discrepancies admission discharge in hospitalized patients explore risk factors their potential clinical impact.An observational prospective study was conducted a general teaching hospital. Patients who were admitted to internal medicine service...
Topical rapamycin is the pharmacological treatment of choice for facial angiofibromas in rare tuberous sclerosis disease. A new, more advanced, and complex formula was developed our pharmacy service: 0.4% liposomal formulation, with better organoleptic characteristics a favorable release profile active ingredient. The purpose this study to evaluate effectiveness safety topical injuries This an observational, prospective, multicenter study. Effectiveness evaluated mainly through Facial...
Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic disease, its management and morbidity impose a great burden to healthcare systems. Development rollout of biological disease modifying anti-rheumatic drugs has contributed improvements for patients, however, high costs have prevented them be widely used. This being addressed with biosimilars, equal benefit-risk profile reduced costs. The objective analyze cost-effectiveness subcutaneous biosimilar tocilizumab (bsTCZ)...
Background/Objectives: Implementing model-informed precision dosing (MIPD) strategies guided by population pharmacokinetic/pharmacodynamic (PK/PD) models could enhance the management of inflammatory diseases such as psoriasis. However, extent individual experimental data gathered during MIPD significantly influences uncertainty in estimating PK/PD parameters, affecting clinical dose selection decisions. Methods: This study proposes a methodology to individualize ustekinumab (UTK) for 23...
Comparar la calidad de dos modelos atención farmacéutica, con y sin integración del farmacéutico en el equipo clínico, pacientes onco-hematológicos hospitalizados. Estudio cohortes prospectivo un hospital universi-tario, los servicios oncología hematología, durante 26 meses. El modelo centralizado (modelo C) se aplicó 16 meses o descentralizado D) 10 restantes. Se utilizó método Iaser© para identificación oportunidades mejora su farmacoterapia seguimiento problemas relacionados medicación...
In addition to respiratory support needs, patients' characteristics guide indication or timing of corticosteroid treatment in COVID-19 patients are not completely established. This study aimed evaluate the impact methylprednisolone on mortality rate with pneumonia-induced severe systemic inflammation (PI-SSI).Between 9 March and 5 May 2020 (final follow-up 2 July 2020), a retrospective cohort was conducted hospitalised PI-SSI (≥2 inflammatory biomarkers [IBs]: temperature ≥38℃, lymphocyte...
CT-P13 is a biosimilar with comparable pharmacokinetics, efficacy and safety to its reference product (RP), infliximab. Studies have shown that switching from RP does not reduce the effectiveness or of treatment. In this retrospective real-world study, patients inflammatory diseases treated were switched (n = 7) continued on 6). Clinical outcomes compared between groups after four treatment cycles. demonstrated RP. All who maintained improved their clinical response, including two remained...
The clinical course of COVID-19 is highly variable. It therefore essential to predict as early and accurately possible the severity level disease in a patient who admitted hospital. This means identifying contributing factors mortality developing an easy-to-use score that could enable fast assessment risk using only information recorded at hospitalization. A large database adult patients with confirmed diagnosis (n = 15,628; 2,846 deceased) Spanish hospitals between December 2019 July 2020...
<h3>Objectives</h3> To determine the prevalence of inappropriate prescribing in elderly patients with polypharmacy admitted to a long-term care hospital (LTCH) and evaluate impact an interdisciplinary pharmacotherapy quality programme on improvement appropriateness. <h3>Methods</h3> An interventional, longitudinal, prospective study was conducted Spanish LTCH (October 2013 July 2014) including 162 (≥70 years) (≥5 medications). Pharmacists follow-up medication reconciliation,...
This article compares gravimetry vs. high-performance liquid chromatography (HPLC) as quality control (QC) methods for paclitaxel, docetaxel and oxaliplatin preparations. We aimed at assessing the preparation method reliability in our hospital, evaluating compounding accuracy estimating influence of personnel training standardized homogenization on accuracy. Agreement, correlation, concordance, precision between were evaluated each drug. Conforming percentages (CPs) different tolerance...
Abstract Objectives The aim of this study was to describe the most common drug-related problems (DRPs) found after discharge, pharmacist interventions and their results for patients enrolled on CONSULTENOS programme. Methods An observational, prospective, multicentre conducted evaluate a pharmaceutical care programme at discharge. Patients from 10 hospitals participating in were enrolled. Pharmacists conducting newly graduated worked under supervision pharmacy staff member; only two...
To evaluate the effectiveness and toxicity profile of ipilimumab treatment to examine cost-effectiveness relation in a real-world sample patients with metastasic melanoma. This was multicenter, observational, retrospective cohorts study. assess safety progression-free survival (PFS), overall (OS) adverse events were registered. An economic evaluation performed ratios (CERs) calculated. Eleven included, mean age 59 (SD=11) years. The median PFS 3.83 months (95% confidence interval 0.98-9.80)...
Aims The aims are to develop a population pharmacokinetic model of capecitabine (CAP) and its main metabolites after the oral administration CAP in colorectal cancer patients with different polymorphisms ATP‐binding cassette (ABC) gene pharmacokinetic/pharmacodynamic capable accounting for neutropenic effects, optimize dosing strategy based on ABC and/or regimen as single agent or combination. Methods Forty‐eight diagnosed were included, 432 plasma levels CAP, 5′‐desoxi‐5‐fluorouridine...