A5022860197- Influenza Virus Research Studies
- Respiratory viral infections research
- Hepatitis C virus research
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Neonatal and fetal brain pathology
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Entomopathogenic Microorganisms in Pest Control
- Chemotherapy-related skin toxicity
- Economic and Financial Impacts of Cancer
- Parvovirus B19 Infection Studies
- Cancer-related cognitive impairment studies
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- CAR-T cell therapy research
- Anesthesia and Neurotoxicity Research
- Health Systems, Economic Evaluations, Quality of Life
- Hematopoietic Stem Cell Transplantation
Puma Biotechnology (United States)
2024
University of Maryland, Baltimore
2018-2021
Hospital Universitario Doctor Peset
2013-2019
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2017-2019
Universitat de València
2016-2017
Hospital Clínico Universitario de Valencia
2016
PET reveals spatially heterogeneous rifampin brain penetration, which decreases rapidly with treatment during tuberculous meningitis.
Sirolimus appears to protect against cytomegalovirus (CMV) in organ transplant recipients. The effect of this drug allogeneic hematopoietic stem cell transplantation recipients remains unexplored. By means multivariate continuous-time Markov model analyses, we identified 3 independent covariates that significantly impacted the risk CMV DNAemia: recipient/donor serostatus, tacrolimus exposure, and sirolimus exposure. CMV-seropositive with CMV-seronegative donors had a higher probability...
Abstract Regulatory T cells (T regs ) are essential for maintaining immune homeostasis by serving as negative regulators of adaptive system effector cell responses. Reduced production or function has been implicated in several human autoimmune diseases. The cytokine interleukin 2 plays a central role promoting reg differentiation, survival, and vivo may therefore have therapeutic benefits mRNA‐6231 is an investigational, lipid nanoparticle‐encapsulated, mRNA‐based therapy that encodes...
The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage viruses. components vaccines used current past two seasons Valencia region were similar but not well matched to dominant influenza-circulating strains. We estimate vaccine effectiveness (IVE) interference previous vaccination preventing admission with or this particular season.The Hospital Network for Study Influenza runs an active surveillance hospital-based study...
Introduction Seasonal influenza vaccination is widely recommended for people with risk factors, especially who are elderly. However, vaccine effectiveness (IVE) varies year after because of the variable antigenic composition circulating viruses and composition. Methods: We summarise results IVE impact previous among subjects 60 years age over in a multicentre prospective study Valencia Hospital Surveillance Network Study Influenza Respiratory Viruses Disease (VAHNSI) Spain. applied...
Highlights•The risk of cytomegalovirus (CMV) DNAemia necessitating antiviral preemptive therapy decreased 6% for each 1 ng/mL increase in sirolimus trough concentrations.•Pharmacometric analysis supports that may have a clinically relevant exposure-dependent anti-CMV effect the allogeneic hematopoietic stem cell transplantation setting.ABSTRACTThe current study evaluates clinical exposure on occurrence therapy. A total 167 consecutive recipients reduced-intensity conditioning (RIC)...
To better understand the impact of seasonal influenza in pregnant women we analyzed data collected during four seasons at a hospital for acute respiratory infection that specializes treating women. This was single-center active surveillance study 15–44 years age hospitalized diseases between 2012/2013 and 2015/2016 Moscow, Russian Federation. Women had to have been within 7 days onset symptoms. Swabs were taken 48 h admission, detected by reverse transcription-polymerase chain reaction....
To evaluate the adequacy of different dosing regimens voriconazole for prophylaxis invasive candidiasis and aspergillosis in adult allogeneic stem cell transplant recipients by means population pharmacokinetic (PK) modelling simulation.Allogeneic receiving were included this observational study. A PK model was developed. Three oral voriconazole-dosing simulated: 200, 300, 400 mg twice daily. The pharmacodynamic target defined as fAUC0-24/0.7. probability attainment ≥90% considered optimal....
To evaluate the effectiveness and toxicity profile of ipilimumab treatment to examine cost-effectiveness relation in a real-world sample patients with metastasic melanoma. This was multicenter, observational, retrospective cohorts study. assess safety progression-free survival (PFS), overall (OS) adverse events were registered. An economic evaluation performed ratios (CERs) calculated. Eleven included, mean age 59 (SD=11) years. The median PFS 3.83 months (95% confidence interval 0.98-9.80)...
The aim of this study was to evaluate the effectiveness and toxicity profile vinflunine chemotherapy regimen examine cost-effectiveness relation in a real-world sample patients with transitional cell carcinoma bladder. This is multicenter, observational, retrospective cohort study. To assess safety treatment, progression-free survival, overall adverse events were registered. An economic evaluation performed ratios calculated. A total 37 included study, mean age 67 (SD=9) years. median...
A wide linearity range analytical method for the determination of lenalidomide in patients with multiple myeloma pharmacokinetic studies is required. Plasma samples were ultrasonicated protein precipitation. solid-phase extraction was performed. The eluted evaporated to dryness under vacuum, and solid obtained diluted injected into high-performance liquid chromatography (HPLC) system. Separation performed on an Xterra RP C18 (250 mm length × 4.6 i.d., 5 µm) using a mobile phase consisting...
The main objective of this study was to develop a pharmacokinetic model in order describe the intestinal absorption erlotinib rat and quantify interaction levofloxacin on process well- under-nourished rats. Absorption studies were performed male Wistar Concentration–time profiles proximal distal intestine analysed through non-linear mixed effect modelling using NONMEM software version 7.3. Simulations explore influence covariates apparent rate constant. A passive an active secretion...
<h3>Background</h3> Protease inhibitor-based triple therapy increases the expected incidence and severity of haematological adverse events, with repercussions on total cost. <h3>Purpose</h3> To assess incidence, management incremental cost thrombocytopenia in chronic hepatitis C virus (HCV) patients treated during first 12 weeks telaprevir/boceprevir-based therapy. <h3>Material methods</h3> Retrospective observational study conducted (June 2012–February 2013) at outpatients department a...